This is Archived Content. This content is available for historical purposes only. It may not reflect the current state of science or language from the National Institute on Drug Abuse (NIDA). View current news releases on nida.nih.gov.
Percentage of adolescents reporting drug use decreased significantly in 2021 as the COVID-19 pandemic endured
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Results from the 2021 Monitoring the Future Survey report substance use behaviors and related attitudes
El porcentaje de adolescentes que reporta consumo de drogas se redujo marcadamente en 2021, mientras persiste la pandemia de COVID-19
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Los resultados de la Encuesta de seguimiento del futuro de 2021 informan sobre comportamientos de uso de sustancias y actitudes relacionadas entre los adolescentes de EE. UU.
Media Briefing: NIH Leaders to speak at the Society for Neuroscience Annual Meeting about NIH COVID-19 research and the neurological implications of COVID-19
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Leaders from across the NIH will brief reporters about on research efforts related to COVID-19 and SARS-CoV-2
Researchers identify brain circuitry in rodents that may be responsible for negative emotional aspects of pain
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Changing the activity of this circuit restored levels of motivation in a pre-clinical model of pain
Investigadores identifican circuitos cerebrales en roedores que pueden ser responsables de los aspectos emocionales negativos del dolor
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Al modificar la actividad de este circuito, los investigadores restablecieron los niveles de motivación en pruebas preclínicas de dolor realizadas con roedores.
Buprenorphine misuse decreased among U.S. adults with opioid use disorder from 2015-2019
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NIH study highlights the need to expand buprenorphine-based treatment while monitoring and reducing misuse
El uso indebido de buprenorfina entre adultos con trastorno por consumo de opioides en EE. UU. disminuyó en el período 2015-2019
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Estudio de los NIH destaca la necesidad de expandir el tratamiento con buprenorfina mientras se monitorea y reduce el uso indebido
The Hidden U.S. COVID-19 Pandemic: Orphaned Children – More than 140,000 U.S. children lost a primary or secondary caregiver due to the COVID-19 pandemic
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Study highlights stark disparities in caregiver deaths by race and ethnicity, calls for urgent public health response
La pandemia oculta de COVID-19 en Estados Unidos: los niños huérfanos Más de 140,000 niños han perdido a un cuidador primario o secundario por la pandemia de COVID-19
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Un nuevo estudio destaca marcadas disparidades en las muertes de cuidadores según raza y etnia, reclama urgente respuesta de salud pública
El riesgo de infecciones posvacunación por SARS-CoV-2 en las personas con trastornos por consumo de drogas puede ser más elevado
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Trastornos de salud concurrentes parecen contribuir al mayor riesgo, sugiere un estudio de los NIH
People with substance use disorders may be at higher risk for SARS-CoV-2 breakthrough infections
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Co-occurring health disorders appear to contribute to increased risk, NIH study suggests
To end HIV epidemic, we must address health disparities
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Expert report cites unequal progress in Southern U.S. and among marginalized groups
Disparities in opioid overdose deaths continue to worsen for Black people, study suggests
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NIH-supported study underscores the need for racially inclusive approach to address the opioid crisis in hard-hit areas
Las disparidades en muertes por sobredosis de opioides continúan empeorando para la población negra, sugiere un estudio
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Un estudio patrocinado por los Institutos Nacionales de la Salud (NIH) destaca la necesidad de una estrategia racialmente inclusiva para abordar la crisis de opioides en áreas muy afectadas
El consumo de marihuana marca un máximo histórico entre adultos de edad universitaria en 2020
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El consumo de marihuana continuó aumentando entre los estudiantes universitarios en los últimos cinco años y se mantuvo en niveles históricamente altos entre los jóvenes de edad similar que no...
Marijuana use at historic high among college-aged adults in 2020
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Marijuana use continued to rise among college students over the past five years and remained at historically high levels among same-aged peers who are not in college in 2020, according...
NIH HEAL Initiative: Research Meets the Moment to Address the Opioid Public Health Crisis
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Directors highlight research results from NIH-funded science and community partnerships
NIH-funded study finds overall rate of drug use among 10-14 year-olds remained stable during the 2020 COVID-19 pandemic
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Adolescents experiencing stress, mental health issues, and hardship most likely to use substances
Words matter: language can reduce mental health and addiction stigma, NIH leaders say
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Appropriate terminology can improve how people with these conditions are treated in health care settings and society
More than 1.5 million children lost a primary or secondary caregiver due to the COVID-19 pandemic
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Addressing the impact of caregiver deaths critical for pediatric mental health, authors note
Más de 1.5 millones de niños perdieron a un cuidador primario o secundario a causa de la pandemia de COVID-19
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Abordar el impacto de la muerte de los cuidadores es crítico para la salud mental pediátrica, observan los autores
Emergency department-administered, high-dose buprenorphine may enhance opioid use disorder treatment outcomes
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Study finds treatment is safe and well tolerated in people with opioid use disorder experiencing withdrawal symptoms
La administración de una dosis alta de buprenorfina en la sala de emergencias puede mejorar el resultado del tratamiento del trastorno por consumo de opioides
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Un estudio encuentra que el tratamiento es seguro y bien tolerado en personas con trastorno por consumo de opioides que experimentan síntomas de abstinencia
El consumo de alcohol y marihuana entre adolescentes se mantiene estable durante la pandemia de COVID-19
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Una encuesta de estudiantes de 12.o grado de Estados Unidos reveló que el consumo de marihuana y los atracones de alcohol entre los adolescentes no variaron en forma significativa durante...
Adolescent marijuana, alcohol use held steady during COVID-19 pandemic
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Adolescent marijuana use and binge drinking did not significantly change during the COVID-19 pandemic, despite record decreases in the substances’ perceived availability, according to a survey of 12th graders in...
Cannabis use may be associated with suicidality in young adults
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NIH study suggests a link between cannabis use and higher levels of suicidal ideation, plan, and attempt
El consumo de cannabis puede estar asociado con suicidalidad en los adultos jóvenes
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Un estudio de los Institutos Nacionales de la Salud (NIH) sugiere un vínculo entre el cannabis y un nivel más alto de ideas, planes e intentos de suicidio
NIH-funded study tests “one-stop” mobile clinics to deliver HIV, substance use care
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Trial underway to determine whether mobile clinics can help improve health outcomes for people with opioid use disorder
Un estudio financiado por los NIH evalúa clínicas móviles integrales para atención de VIH, consumo de drogas
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Ensayo en curso para determinar si las clínicas móviles pueden ayudar a mejorar los resultados de salud de las personas con trastorno por consumo de opioides
Long-lasting medications may improve treatment satisfaction in people with opioid use disorder
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NIH leaders emphasize the importance of patient voices in addiction medication development
Los fármacos de efecto prolongado pueden aumentar la satisfacción con el tratamiento para los pacientes con trastorno por consumo de opioides
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Los líderes de los NIH enfatizan la importancia de las voces de los pacientes en el desarrollo de medicamentos para la adicción
Medical records analysis links cannabis use disorder in pregnancy to infant health problems
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Study adds to a growing body of evidence that prenatal exposure to cannabis may be associated with poor birth outcomes
Un análisis de registros médicos vincula el trastorno por consumo de cannabis durante el embarazo con problemas de salud del bebé
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El estudio se suma a un creciente cuerpo de evidencia de que la exposición prenatal al cannabis puede estar asociada con malos resultados en el parto.
Study links structural brain changes to behavioral problems in children who snore
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Behavioral problems in children who snore may be associated with changes in the structure of their brain’s frontal lobe
Younger age of first cannabis use or prescription drug misuse is associated with faster development of substance use disorders
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NIH analysis measures the prevalence of nine substance use disorders after first substance use or misuse in young people
El consumo inicial de cannabis o el primer uso indebido de medicamentos recetados a edad más temprana están asociados con la aparición más rápida de trastornos por consumo de drogas
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Un análisis de los Institutos Nacionales de la Salud (NIH) mide la prevalencia de nueve trastornos por consumo de drogas en los jóvenes después del consumo o uso indebido inicial
Law enforcement seizures of methamphetamine, marijuana rose during pandemic
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Analysis of illegal drug confiscations in five key U.S. regions suggests new drug supply patterns since COVID-19
Using Smartphone Apps to Reach Gay and Bisexual Men at Risk for HIV
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Finding better ways to reach people at higher risk of HIV for testing and engagement with HIV prevention and treatment services
Co-located HIV Services Can Help Women Who Inject Drugs Access PrEP, Study Shows
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Daily, PrEP (pre-exposure prophylaxis medication), is proven to prevent HIV transmission from injection drug use or sex.
Methamphetamine overdose deaths rise sharply nationwide
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NIH-supported study finds biggest increase among American Indians and Alaska Natives
Combination treatment for methamphetamine use disorder shows promise in NIH study
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Combination medication may be effective in treating adults with methamphetamine use disorder
Un estudio de los Institutos Nacionales de la Salud (NIH) identifica promisorio tratamiento combinado para el trastorno por consumo de metanfetamina
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Combinación de fármacos promete eficacia para tratar el trastorno por consumo de metanfetamina en adultos
Physician-pharmacist collaboration may increase adherence to opioid addiction treatment
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NIH-supported pilot study found team-based approach may improve buprenorphine care
Substance Use Status Important When Developing HIV Therapies
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Animal studies suggest that subjects with HIV who suffer from opioid use disorders may have higher viral reservoirs in the central nervous system than non-opioid users.
Unraveling neuroHIV in the Presence of Substance Use Disorders
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These reviews address how each of these addictive substances and HIV individually or collectively affect the immune system and subsequent clinical and behavioral outcomes
Estudio: Se estabiliza el aumento del vapeo entre adolescentes a principios de 2020, aunque continúa siendo alto
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Los hallazgos indican que los niveles de vapeo de nicotina y marihuana no aumentaron desde 2019 hasta principios de 2020, aunque siguen siendo altos.
Study: Surge of teen vaping levels off, but remains high as of early 2020
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Annual Monitoring the Future (MTF) survey results released.
Elite Controllers May Hold Key to an HIV Cure
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"Science" Magazine Breakthrough of the Year Runner Up for 2020
Amy Hauck Newman appointed to lead NIDA’s Intramural Research Program
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Dr. Newman officially began her new position at the NIDA IRP on November 22, 2020.
HIV and Methamphetamine Use: Double Jeopardy for Transmission of the Novel Coronavirus.
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The authors suggest that co-occurring methamphetamine use and HIV present a double jeopardy for COVID.
Neighborhood conditions associated with children’s cognitive function
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NIH-funded research from ABCD Study finds association despite household income.
NIH study tests a comprehensive model intervention to reduce opioid overdose deaths in hard-hit communities
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COVID-19 brings challenges, learning opportunities
NIH-funded study links adolescent brain differences to increased waist circumference
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Finding from ABCD Study elucidates neural mechanisms that may underlie early weight gain
Gaps in Substance Use Treatment Services for HIV Patients Around the Globe
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Substance use is common among people living with HIV and is associated with less successful HIV treatment outcomes. Integrating substance use services into HIV care is a promising strategy to...
Vaping, marijuana use in 2019 rose in college-age adults
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Increases are among the largest in history of national study
Mayor vapeo, consumo de marihuana en 2019 entre jóvenes de edad universitaria
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Los aumentos se encuentran entre los más altos registrados en la historia de la encuesta nacional
Substance use disorders linked to COVID-19 susceptibility
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NIH research finds higher risk and worse outcomes for those with addiction
Treating Substance Use Disorders Can Reduce HIV Burden in U.S. Cities
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Concerted efforts and substantial investments in HIV prevention and care in the United States have resulted in considerable reduction in new diagnoses and death since the mid-1990s. To identify best...
Clues to Regulating HIV-1 Viral Gene Expression
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People with substance use disorders (SUD) can be at high risk for contracting this virus, either through injection drug use, or risky behaviors prompted by impaired judgment.
E-cigarette use associated with risk of relapse among former cigarette smokers
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This study has shown that among former smokers, use of electronic nicotine delivery systems (ENDS), including e-cigarettes and other e-products, is associated with increased chance of cigarette smoking relapse.
Shape shifters: The dynamic role of GCPRs in drug discovery
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A new computational analysis suggests certain dopamine receptors in the brain and body are more complex and dynamic than previously thought, existing in diverse inactive states that only allow the binding of specific drugs.
NIDA launches drug education booklet series for middle school students
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The National Institute on Drug Abuse (NIDA) has launched a redesigned series of booklets geared towards educating middle school students about substance use. The Mind Matters series consists of nine...
Learning how to disrupt cocaine’s effects on the brain
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Just published research by scientists at NIDA’s Intramural Research Program reveals that the drug cocaine causes neurons to synthesize endocannabinoids that are then enclosed within membrane-bound packages, known as extracellular vesicles. Designing drugs or tools to manipulate the protein interactions underlying vesicle release could provide a new way to counter cocaine addiction.
Landmark study of adolescent brain development renews for additional seven years
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With nearly $290M of new funding for seven years to research institutions around the country, the National Institutes of Health renewed its commitment to the Adolescent Brain Cognitive Development (ABCD) Study, the largest long-term study of brain development and child health ever conducted in the United States.
Dopamine found to play unexpected role in cocaine withdrawal
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This study has linked cocaine withdrawal to altered gene expression in a brain region affected by addiction.
Marijuana vaping and edible use increasing among high school seniors
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A new analysis suggests that among adolescent marijuana users, smoking has become less prevalent, eclipsed by vaping and edibles.
NIDA Director outlines potential risks to people who smoke and use drugs during COVID-19 pandemic
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The precarious intersection of the COVID-19 national health emergency and the concurrent epidemic of drug overdose deaths is outlined in the Annals of Internal Medicine this week by Dr. Nora D. Volkow, director of the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health.
Stigma and addiction addressed in New England Journal of Medicine
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In a perspective released today in The New England Journal of Medicine, NIDA Director Dr. Nora Volkow addresses how stigma against people who use drugs can sabotage effective treatment.
Dopamine Neurons Signal Rich Information About Unexpected Events
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In this study, both rats and humans learned to predict differently flavored rewards in parallel choice tasks, showing that dopamine neurons are carrying much more information than previously thought.
New biological clues linking social connectedness to reduced drug craving and relapse
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This rodent study offers the first mechanistic explanation for the protective effect of social interaction related to incubation of craving, showing for the first time the role of a specific enzyme (PKCδ) in any learned or motivated behavior, as well as the critical role of a peptide in the brain’s central amygdala (somatostatin).
National Drug and Alcohol Facts Week® celebrates 10 years
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NDAFW is an annual, week-long observance in which local educational events link teens with science-based facts about drugs and alcohol through live and online activities across the country.
Study highlights effectiveness of methadone and buprenorphine
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In a comparative effectiveness study of 6 approaches to treatment for opioid use disorders, only treatment with buprenorphine or methadone was associated with reduced risk of overdose and serious opioid-related acute care use.
NIDA scientists: Blocking adenosine receptors should counteract adverse effects of cannabinoids
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Computational modeling by NIDA scientists suggests the possible use of adenosine A2A receptor antagonists to counteract the adverse effects of cannabinoids.
Babies exposed to HCV not adequately tested
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NIDA-funded science has found that HCV exposed infants might not be commonly or adequately tested.
Many teens who overdose on opioids do not get effective follow-up
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An analysis of Medicaid records shows that less than one-third of youths treated for a nonfatal opioid overdose received timely follow-up treatment, and only 1 in 54 youths received recommended evidence-based medications.
Coaxing the brain to pay attention to healthier choices
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Neuroscience research from NIDA’s Intramural Research Program suggests that cortical mechanisms, especially in the orbitofrontal cortex, are likely involved in attentional bias to cocaine associated environmental cues and offer a targeted location for research.
Changing the way we view opioid receptors
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Newly published research from NIDA funded scientists offers new insight into how opioid receptors work to regulate chemical communication in the brain. The researchers discover unexpected receptor mobility and diffusion, and also find that receptor binding and signaling can occur in separate steps.
Vaping of marijuana on the rise among teens
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Findings from the 2019 Monitoring the Future (MTF) survey demonstrate the appeal of vaping to teens, as seen in the increased prevalence of marijuana use as well as nicotine vaping.
Measuring the complex path to a prescription opioid use disorder
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NIDA scientists examine an accepted model of the causes of depression to determine its usefulness as a foundation to predict the probability of prescription opioid use disorder.
New discovery on the brain’s reward pathway
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Scientists at NIDA’s Intramural Research Program (IRP) have identified a population of neurons engaged in the compulsive nature of food seeking, which, like substance use, engage the brain’s reward circuit. Investigators have identified lateral hypothalamic leptin receptor-expressing neurons as modulators within the hypothalamic-ventral tegmental circuit that relates to motivation and reward.
NIH-funded study finds teens prefer mint and mango vaping flavors
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A new analysis suggests that teens prefer mint and mango as their vaping flavors of choice for e-cigarettes
Healing the altered brains of smokers
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A study from NIDA’s Intramural Research Program illuminates the roles of the brain’s striatum and habenula in nicotine withdrawal and reward, suggesting that current medications for smoking cessation are not targeting the optimal parts of the brain, leading to ongoing reward processing deficits that could make pleasurable activities less enjoyable.
Who is most likely to become addicted to nicotine?
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NIDA scientists discover that connectivity between insular regions of the brain before using nicotine can predict severity of addiction.
Nicotine addiction linked to diabetes through a DNA-regulating gene in animal models
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Researchers have discovered a mechanism in rats that links cigarette smoking and the risk of developing type 2 diabetes.
Measuring sleep challenges in opioid use disorder patients
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A new study at NIDA’s Intramural Research Center measured sleep patterns in opioid use disorder patients and found that clinic appointment hours make a difference in sleep quality. They also documented that when patients use opioids or other drugs while undergoing treatment, it disrupts their sleep.
Teen e-cigarette use doubles since 2017
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Data from the 2019 Monitoring the Future Survey of eighth, 10th and 12th graders show alarmingly high rates of e-cigarette use compared to just a year ago, with rates doubling in the past two years.
Marijuana use at historic highs among college-age adults
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Newly released Monitoring the Future (MTF) survey data on drug use in college-age adults ages 19-22 shows an increase in marijuana use in the past five years, including vaping with marijuana, as well as a significant increase in nicotine vaping.
NASEM releases National Agenda on Children’s Behavioral Health
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The National Academies of Sciences, Engineering and Medicine has released a national scientific agenda on Fostering Healthy Mental, Emotional, and Behavioral Development in Children and Youth, recommending a comprehensive approach to better prevent poor outcomes in children related to mental health and substance use. The report notes that despite the development of effective evidence-based programs in recent years, much of what we know has not yet been implemented in many communities, and rates of depression, suicide, and self-harm among young people have actually been increasing.
Unraveling the mystery of the glutamate-dopamine connection
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Investigators identify a subpopulation of calbindin neurons with the capability to co-release glutamate and dopamine in the nucleus accumbens shell.
Worms lead scientists to a new anti-opioid system
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A team of NIH-funded scientists used worms to discover a surprising biological system that counteracts the effects of opioids, offering a potential new target for improving the safety of opioid pain relievers.
New findings could lead to reduced replication of the HIV virus
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In this study, NIDA-funded scientists found that the HIV RNA genome has two previously unknown types of RNA marks.
Teens who misuse medicines get them from multiple sources
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Two NIDA-funded studies have found that adolescents using multiple sources for prescription medications are at high risk for other substance use.
Co-prescribing naloxone in Medicare Part D increases
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A study found that overall national rates for naloxone co-prescription along with any opioid among Medicare Part D patients increased from 1.5 per 1000 patients receiving opioid prescriptions in 2016 to 4.6 per 1000 in 2017.
First time drug use more common in summertime
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Government surveys showed that in 2017, an estimated three million people tried marijuana for the first time, just over a million tried cocaine, close to 800,000 tried LSD, and close to 790,000 initiated use of ecstasy (MDMA/Molly).
Parenting programs lead to healthier behaviors
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A study conducted among 517 youth in the rural areas of the southeastern United States demonstrates the effectiveness of a parenting enhancement program in both preventing drug use and obesity, two potentially life-threatening conditions for which people living in disadvantaged communities are at an elevated risk.
NIH establishes network to improve opioid addiction treatment in criminal justice settings
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The National Institutes of Health will award 12 grants to form the Justice Community Opioid Innovation Network (JCOIN) to support research on quality addiction treatment for opioid use disorder (OUD) in criminal justice settings nationwide.
Similarities between aggressive and addictive behaviors
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Scientists from NIDA’s Intramural Research Program show that neural mechanisms that control appetitive aggressive behavior are similar to those that control drug-taking and seeking (relapse), suggesting common neurobiological mechanisms of aggression reward and drug reward.
Prescription opioid misuse in high school linked to later heroin use
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A NIDA-funded study suggests that misuse of prescription opioid pain relievers in high school could be linked to heroin use later in life.
Medical Marijuana Laws and Opioid Overdose Rates
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A new study underscores the need for additional research on the effect of medical marijuana laws on opioid overdose deaths and cautions against drawing a causal connection between the two.
Female reproductive cycle affects cocaine craving in animal study
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Researchers at NIDA’s Intramural Research Program (IRP) wanted to determine if the incubation of craving would be different in male and female rats and if the effect is stronger after binge cocaine intake, compared to continuous use.