INVEST Fellow Validates Noninvasive Drug-Testing Methods

INVEST Fellow Dr. Marta Concheiro Guisán, Spain, ended her successful drug abuse research fellowship having developed and validated two new, noninvasive methods to quantify the level of licit and illicit drugs in biological samples from opiate-dependent patients, as well as publishing several scientific articles and presenting her research at scientific meetings. The new methods developed by Dr. Concheiro and her mentor, Dr. Marilyn Huestis, NIDA Intramural Research Program (IRP), permit researchers to quantify quickly and simultaneously 16 drugs and their metabolites in oral fluid or 14 drugs and their metabolites in sweat patches. The methods were validated using specimens from a group of opioid-dependent, buprenorphine-maintained pregnant women enrolled in a joint Johns Hopkins University/NIDA IRP randomized controlled clinical trial that compares methadone versus buprenorphine treatment. Drs. Concheiro, Heustis, and their colleagues published articles in Analytical and Bioanalytical Chemistry (2009) 394(2):513–522; Forensic Science International (2009) 188(1–3):144–145; Clinical Chemistry (2009) 55(6):1177–1187; Journal of Analytical Toxicology (2009) 33(5):243–252; and Journal of Chromatography B (2009) 877(27):3065–3071. Dr. Concheiro also presented her research at the 2009 meetings of the Society of Forensic Toxicologists, International Association of Therapeutic Drug Monitoring and Clinical Toxicology, College on Problems of Drug Dependence, and NIDA International Forum. Dr. Concheiro has returned to research and teaching in the Forensic Toxicology Service, University of Santiago de Compostela Faculty of Medicine, and is planning future collaborations with Dr. Huestis.