As part of the ongoing collaboration under the binational agreement between NIDA and the Italian Department for Antidrug Policies, the NIDA Intramural Research Program (IRP) and researchers at the Catholic University of Rome will conduct joint clinical studies on reducing alcohol consumption. The Italian principal investigator is Giovanni Addolorato, M.D. The research plan was agreed upon during meetings that were held November 6–14, 2012, in Rome and Verona, where NIDA Director Nora D. Volkow, M.D., and IRP Scientific Director Antonello Bonci, M.D., discussed the role of drugs in the disruption of self-control and strategies to prevent and treat addiction.