In a special issue of the Journal of Neuroimmune Pharmacology, ten review papers by NIDA grantees and scientists highlight the interactive, additive, or synergistic effects of substance use disorders with HIV infection on the immune system. These papers explore how the use and misuse of opioids, tobacco, stimulants, and cannabis along with comorbid HIV impact the dopaminergic and immune systems and the subsequent neurological and behavioral disorders known as HIV-associated neurocognitive disorders (HAND).
These reviews address how each of these addictive substances and HIV individually or collectively affect the immune system at the cellular, molecular, and system levels, and subsequent clinical and behavioral outcomes. The authors also identify gaps, confounds, or constraints in the current disease models and approaches, and propose future research directions.
The papers were originally presented during a NIDA preconference workshop at the 25th Society on NeuroImmune Pharmacology conference in 2019, and links are presented here as a courtesy from the NIDA HIV Research Program.
The individual papers can be found here:
- Introductory Commentary: Unraveling neuroHIV in the Presence of Substance Use Disorders -- Yu Lin, Johnny J. He, Roger Sorensen & Linda Chang
- Effect of Opioid Use on Immune Activation and HIV Persistence on ART -- Livio Azzoni, David Metzger, Luis J. Montaner
- Opioid and neuroHIV Comorbidity – Current and Future Perspectives -- Sylvia Fitting, Mary Peace McRae, Kurt F Hauser
- Opioid-Mediated HIV-1 Immunopathogenesis -- Shilpa Buch, Palsamy Periyasamy, Annadurai Thangaraj, Susmita Sil, Ernest T. Chivero, Ashutosh Tripathi
- Methamphetamine and Cannabis: A Tale of Two Drugs and their Effects on HIV, Brain, and Behavior -- Rowan Saloner, Jerel Adam Fields, Maria Cecilia Garibaldi Marcondes, Jennifer E. Iudicello, Sofie von Känel, Mariana Cherner, Scott L. Letendre, Marcus Kaul, Igor Grant, the Translational Methamphetamine AIDS Research Center (TMARC) Group
- HIV Neuropathogenesis in the Presence of a Disrupted Dopamine System -- E. A. Nickoloff-Bybel, T. M. Calderon, P. J. Gaskill, J. W. Berman
- HIV Infection and Neurocognitive Disorders in the Context of Chronic Drug Abuse: Evidence for Divergent Findings Dependent upon Prior Drug History – Jessica M. Illenberger, Steven B. Harrod, Charles F.Mactutus, Kristen A.McLaurin, Asha Kallianpur, Rosemarie M. Booze
- Reciprocal Influences of HIV and Cannabinoids on the Brain and Cognitive Function -- Sheri L. Towe, Christina S. Meade, Christine C. Cloak, Ryan P. Bell, Julian Baptiste, Linda Chang
- Targeting Cannabinoid Receptor 2 on Peripheral Leukocytes to Attenuate Inflammatory Mechanisms Implicated in HIV-Associated Neurocognitive Disorder -- Michael D. Rizzo, Joseph E. Henriquez, Lance K. Blevins, Anthony Bach, Robert B. Crawford, Norbert E. Kaminski
- Independent and Combined Effects of Nicotine or Chronic Tobacco Smoking and HIV on the Brain: A Review of Preclinical and Clinical Studies -- Linda Chang, Huajun Liang, Suresh R. Kandel, Johnny J. He
- Bidirectional Associations among Nicotine and Tobacco Smoke, NeuroHIV, and Antiretroviral Therapy -- Shivesh Ghura, Robert Gross, Kelly Jordan-Sciutto, Jacob Dubroff, Robert Schnoll, Ronald G. Collman, Rebecca L. Ashare
Table of Contents link: https://link.springer.com/journal/11481/volumes-and-issues/15-4