NIDA Genetic Consortium Meetings & Abstracts Archives

Abstracts and Agenda from May 2023 meeting

Welcome

The Genetics and Epigenetics Cross-Cutting Research Team of the National Institute on Drug Abuse invites you to attend the May 16-17, 2023 NIDA Genetics and Epigenetics Cross-Cutting Research Team Meeting at Natcher Auditorium on the NIH Campus in Bethesda, MD. This is an in-person meeting. We expect to have more than 215 scientific presentations.

Meeting Dates and Times

Tuesday, May 16^th: - 9:00 a.m. to 5:30 p.m.
Wednesday, May 17^th - 9:00 a.m. to 5:00 p.m.

Agenda and Meeting Abstracts

May 16 – Keynote (9:15 am – 9:45 am)
Time	First Name	Last Name	Email	Abstract Title
9:15	Andre	Toussaint	at3658@columbia.edu	Understanding Substance Abuse from Scientific and Human Perspectives

May 16 – Session 1 (9:45 am – 11:00 am) - Single cell transcriptional and chromatin profiling of brain reward structures identifies new candidate targets in substance use disorders Eric Nestler and Jeremy Day, Chairs
Time	First Name	Last Name	Email	Abstract Title
9:45	Kristen	Maynard	kristen.maynard@libd.org	Integrated single cell and spatial transcriptomic approaches for defining the molecular anatomy of reward circuitry in the human brain
10:00	Marine	Salery	marine.salery@mssm.edu	Capturing and profiling cocaine-recruited Arc neuronal ensembles encoding drug-context associations in the Nucleus Accumbens.
10:15	Jennifer	Tuscher	jtuscher@uab.edu	Multiomic profiling of the rat nucleus accumbens reveals cell-type specific chromatin remodeling and transcriptional alterations after cocaine experience
10:30	Benjamin	Reiner	bcreiner@pennmedicine.upenn.edu	Single nuclei transcriptomic analysis of rat nucleus accumbens reveals cell type-specific patterns of gene expression associated with volitional morphine

May 16 – Special Presentation (11:00 am – 11:10 am)
Time	First Name	Last Name	Email	Abstract Title
11:00	Anita	Bandrowski	bandrow@gmail.com	RRIDs and where they fit into known standards such as the ARRIVE 2.0 guidelines

May 16 – Session 2 (2:00 pm – 3:00 pm) Artificial Intelligence (AI) Application in Genetics and Epigenomics Carl Lin and Sara Mostafavi, Chairs
Time	First Name	Last Name	Email	Abstract Title
2:00	Carl	Lin	zlin@mclean.harvard.edu	History and Application of Artificial Intelligence: Its Turn for Genomics
2:00	Sara	Mostafavi	saramos@cs.washington.edu	Sequence-based deep learning models for predicting molecular phenotypes
2:15	Hongyang	Li	Hongyang.Li@ibm.com	Asymmetric Predictive Relationships Across Histone Modifications
2:30	Andreas	Pfenning	apfenning@cmu.edu	Fine-mapping candidate neuropsychiatric regulatory variants using cell type-aware comparative genomics

May – 16 Session 3 (4:30 pm – 5:20 pm) - Short Talk Presentations
Time	First Name	Last Name	Email	Abstract Title
4:30	Alexander	Hatoum	ashatoum@wustl.edu	Multivariate genome-wide assocation meta-analysis of 1 million subjects identifies loci underlying multiple substance use disorders
4:40	Jeffrey	Hatfield	jshatfi@g.clemson.edu	Cocaine Preference in the Drosophila melanogaster Genetic Reference Panel
4:50	Chelsie	Benca-Bachman	chelsie.benca@emory.edu	Additive Genetic and Interactive Effects on Alcohol Problems and Traumatic Experiences Among African Americans
4:55	Xiufang (Nadine)	Guo	xguo@mail.ucf.edu	Development of an iPSC-preBötC neuron opiate overdose and recovery multi-organ platform
5:00	Jennifer	Kelschenbach	jennifer.kelschenbach@mssm.edu	Morphine dependence accelerates HIV-associated neurocognitive impairment in EcoHIV infected mice
5:05	Salma	Majid	majidsn@nih.gov	Recurrent and non-recurrent copy number variants in American Indian tribes with substance use disorders
5:10	Freddyson	Martinez-Rivera	freddyson.martinez-rivera@mssm.edu	Cellular and transcriptional contributions of the nucleus accumbens in transferring extinction-based memories
5:15	Evaristus	Nwulia	enwulia@howard.edu	Linking Cannabis Use Disorder, Long-noncoding RNA and Olfactory Structure and Function

May 17 – Session 4 (9:00 am – 10:15 am) - Non-Cannonical regulation of gene-expression by drugs with addictive properties Elizabeth Heller and Zhzhu Zhang, Chairs
Time	First Name	Last Name	Email	Abstract Title
9:00	Elizabeth	Heller	eheller@pennmedicine.upenn.edu	Cocaine regulation of alternative splicing via changes in histone postranslational modifications.
9:15	Zijun	Wang	zjwang@ku.edu	DNA damage and repair processes are involved in opioid addiction
9:30	Zhuzhu	Zhang	zhuzhuzhang@uchicago.edu	Epigenomic remodeling at single cell resolution in cocaine self-administration in mice
9:45	BaDoi	Phan	badoi.phan@pitt.edu	Whole-animal massively parallel reporter assay dissects the region-specific transcriptional impact of human addiction genetic variants

May 17 – Session 5 (1:15 pm – 2:30 pm) - The Role of Behavioral Undercontrol in Mediating Genetic Risk for Substance Use Disorders Abraham Palmer and Danielle Dick, Chairs
Time	First Name	Last Name	Email	Abstract Title
1:15	Holly	Poore	holly.poore@rutgers.edu	Characterizing the Genetic Overlap between Externalizing Phenotypes and Substance Use Disorders
1:30	Sandra	Sanchez-Roige	sanchezroige@ucsd.edu	CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice
1:45	Huda	Akil	akil@umich.edu	Selectively Breeding for Temperament and Vulnerability to Addiction: A Genetic, Genomic and Neural Characterization of Behavioral Undercontrol and Overcontrol.
2:00	Michael	Sheldon	michael.sheldon@sampled.com	Biobanking as a Foundational Component of NIH Research: The NIDA Center for Genetic Studies Provides A Critical Resource for Research into the Genetics and Epigenetics of Substance Abuse

May – 17 Session 6 (4:00 pm – 4:50 pm) - Short Talk Presentations
Time	First Name	Last Name	Email	Abstract Title
4:00	Amrit	Koirala	amrit.koirala@bcm.edu	Deconvolution of microRNA/mRNA Networks in Brain Regions Impacted by Cocaine Use Disorder to Develop a Mechanistic Biosignature for Pharmacotherapy Response
4:10	Vivek	Philip	Vivek.Philip@jax.org	Enumeration and visualization of differential gene co-expression response to cocaine
4:20	Janitza	Montalvo-Ortiz	janitza.montalvo-ortiz@yale.edu	Deciphering the role of DNA hydroxymethylation in substance use disorders
4:25	MadhurBain	Singh	singhm18@vcu.edu	Examining Bidirectional Causal Effects between Smoking and DNA Methylation using Epigenetic Mendelian Randomization Analyses
4:30	Alyssa	Wilson	alyssa.wilson@mssm.edu	Identifying Cell-Type-Specific Transcriptional Changes in Midbrain in the Context of Substance Use Disorder and Long-Term HIV Infection: A Cohort Study at the Manhattan HIV Brain Bank
4:35	Francesca	Telese	ftelese@health.ucsd.edu	Analysis of single nuclei RNA-seq from the nucleus accumbens of heterozygous reeler mice exposed to THC during adolescence suggests a link between THC exposure, Reelin signaling, and vulnerability to human psychiatric disorders
4:40	Jared	Bagley	jbagley@binghamton.edu	Neuron navigator 1 regulates the self-administration of cocaine
4:45	Laura	Saba	Laura.Saba@cuanschutz.edu	Multi-omic single nuclei data provide insight into the cellular origin of whole brain coexpression patterns related to Oprm1

May 16 – Poster Session A (11:10 am – 12:40 pm)
Poster #	First Name	Last Name	Email	Abstract Title
1	Arpana	Agrawal	arpana@wustl.edu	The Psychiatric Genomics Consortium Substance Use Disorders Working Group (PGC-SUD): An Update
2	Schahram	Akbarian	schahram.akbarian@mssm.edu	Single Nucleus Transcriptomic Profiling of Human Ventral Midbrain Reveals Widespread Activation of Multiple Glial Subtype
3	Muhammad	Arshad	muhammadwaqar.arshad@yale.edu	Substance Abuse in Pakistan: Clinical Issues and Research Opportunities
4	Bao-Zhu	Yang	bao-zhu.yang@yale.edu	Inter-Linking the Developmental Brain Transcriptome and GWAS Risk Variants Revealed Neural Circuits Prognostic of Nicotine Use Severity
5	David	Ashbrook	dashbrook@UTHSC.edu	Good wine and old data get better with age: New insights on gene-by-environment effects of drugs of abuse in mice using GeneNetwork.org
6	Christopher	Baker	christopher.baker@jax.org	Genetic variation influences cell specific cis-regulatory landscape in the mouse striatum
7	Madelyn	Baker	mrb4002@med.cornell.edu	Epigenetic representation of cocaine-context association in the dorsal dentate gyrus of male mice
8	Britahny	Baskin	britty@bu.edu	Premorbid addiction model traits and cocaine stimulant sensitivity in spontaneously hypertensive rat (SHR) substrains
9	Jacob	Beierle	Jacob.Beierle@jax.org	A high-throughput machine vision-based univariate scale for pain and analgesia in mice
10	Aritra	Bhattacherjee	writetoab@gmail.com	Decoding molecular organization of the brain reward circuit for understanding mechanisms of drug addiction
11	Chuan	Bi	chuan.bi@som.umaryland.edu	Multivariate Mediation Analysis of Genetic Variants, Brain Connectome and Nicotine Addiction
12	Fatah	Kashanchi	fkashanc@gmu.edu	Retroviral infection of human neurospheres and use of stem cell EVs to repair cellular damage
13	Kasey	Brida	kbrida@uab.edu	Reelin protein marks cocaine-sensitive Drd1+ medium spiny neurons and modulates medium spiny neuron physiology and behavioral response to cocaine
14	Russell	Brown	BROWN1@mail.etsu.edu	Analysis of the enhanced rewarding effects of nicotine and underlying neuroplasticity mechanisms in a heritable model of drug abuse vulnerability in psychosis
15	Caleb	Browne	caleb.browne@mssm.edu	Transcriptome profiling of the brain’s reward circuitry in heroin self-administration identifies a ventral hippocampus gene network related to relapse susceptibility
16	Edward	Browne	epbrowne@email.unc.edu	Defining the impact of cannabis use on immune cell phenotypes and the latent viral reservoir in people with HIV.
17	Camron	Bryant	camron@bu.edu	Spectrotemporal USV profiles during neonatal opioid withdrawal in FVB substrains, Zhx2-edited BALB/c substrains, and outbred CFW mice
18	Jason	Bubier	Jason.Bubier@jax.org	A Tale of Two Opioids: The Genetics of Opioid Induced Respiratory Depression in Response to Fentanyl and Morphine in Mice.
19	Belle	Buzzi	buzzib@vcu.edu	Nicotine reward and preference in C57BL/6J and C57BL/6N mouse strains
20	Jean Lud	Cadet	jcadet@intra.nida.nih.gov	Compulsive methamphetamine intake and abstinence in the presence of punishment are associated with differential hydroxymethylation of miRNAs in the rat nucleus accumbens
21	Cali	Calarco	ccalarco@som.umaryland.edu	Mitochondrial gene ontology pathways and transcriptional regulators impacted by cocaine in C57Bl/6 mice
22	Rianne	Campbell	rcampbell@som.umaryland.edu	Baseline Characterizations of Novel D1R-CRISPRa and A2A-CRISPRa Mouse Lines
23	Javan	Carter	JCarter@rti.org	Identifying novel genes and pathways associated with opioid overdose death via meta-analysis of differential gene expression.
24	Samantha	Cheeks	scheeks@uci.edu	Cannabidiol Attenuates Nicotine Self-Administration and Withdrawal Symptomology in Mice
25	Jixin	Chen	chenj@ohio.edu	A single-molecule FRET data fitting package for DNA folding kinetic study
26	Yong	Chen	chenyong@rowan.edu	Inferring Memory-related Regulatory Modules in Engram Cells by Deep-learning and scRNA-seq Data
27	Olivia	Corradin	corradin@wi.mit.edu	Case-specific epigenetic alterations converge on key genes linked to opioid overdose
28	Daniel	Wood	woodda@musc.edu	HDAC5 intrinsic enzymatic activity limits drug-seeking behavior
29	Santiago	Cuesta	santiago.cuesta@rutgers.edu	Gut Microbiota Composition Modulates Cocaine-Induced Neurobehavioral Plasticity
30	Eamonn	Duffy	Eamonn.Duffy@colorado.edu	Characterization of thermal and mechanical sensitivity in select strains of the Hybrid Rat Diversity Panel
31	Soren	Emerson	soren.d.emerson@vanderbilt.edu	Lysine acetyltransferase KAT2a is a novel cocaine-recruited epigenetic regulator in the nucleus accumbens
32	Dan	Fabris	dan.fabris@uconn.edu	Investigating epitranscriptomic communications between HIV-1 infection and neuromodulator response in different CNS cells
33	Fang	Fang	ffang@rti.org	A DNA methylation-based classifier for lifetime cannabis use
34	J. Adam	Fields	jafields@health.ucsd.edu	Effects of cannabinoids on phenotype of patient monocyte-derived macrophages vary by cannabis use patterns
35	Zoe	Figueroa	zoe.figueroa@email.ucr.edu	Astrocytic contributions to chronic methamphetamine induced neuroinflammation and disease
36	Prescilla	Garcia-Trevizo	pjg5435@psu.edu	Long-term Effects of Adolescent Nicotine Exposure on Sensitivity and Cotinine in the Diversity Outbred Mouse Population.
37	Paige	Lemen	plemen1@uthsc.edu	Adolescent Social Isolation Increases Vulnerability to Voluntary Opioid Consumption in Adulthood in Rats
38	Mudit	Tyagi	Mudit.Tyagi@jefferson.edu	Cocaine by co-stimulating NF-kB, NFAT, and AP-1 enhances CD4+ T-cells metabolism; thus, sensitizes partially active cells for HIV infection
39	Min-Ae	Song	song.991@osu.edu	Epigenetic Aging in the Human Lung: Focus on Smoking and Vaping

May 16 – Poster Session B (3:00 pm – 4:30 pm)
Poster #	First Name	Last Name	Email	Abstract Title
1	Vivek	Swarup	vswarup@uci.edu	Investigating multi-omic Mechanisms Underlying Opioid Addiction Vulnerability: A Multi-Omics Study
2	Colin	Hodgkinson	chodg@mail.nih.gov	Alcohol and stress additively accelerate epigenetic cellular age
3	Rodrigo	Grassi-Oliveira	rogo@clin.au.dk	Exposomics of Cocaine Use Disorder: A new paradigm to study the impact of environmental exposures in Substance Use Disorders
4	Benjamin	Grissom	BGrissom@som.umaryland.edu	Heroin-induced genomic regulation of ventral pallidum and nucleus accumbens neuron subtypes
5	Petar	Grozdanov	petar.grozdanov@ttuhsc.edu	The role of alternative polyadenylation in a TLR3-mediated mouse model of escalated alcohol consumption
6	Hongsheng	Gui	hgui1@hfhs.org	Bivariate relationship between opioid use disorder and suicide attempts despite mental health
7	Megan	Hagenauer	hagenaue@umich.edu	The Brain Data Alchemy Project: Teaching Research Reproducibility and Discovery Science While Mining Gold from Archived Genomics Data
8	Nikhil	Hajirnis	nhajirnis@som.umaryland.edu	Epigenomic editing of nucleus accumbens neuron subtypes using the CRISPR-Cas12f derived system
9	Peter	Hamilton	peter.hamilton@vcuhealth.org	Synthetic transcription factors, delivered to mouse nucleus accumbens, dysregulate drug-specific transcription and behaviors
10	Shuanglin	Hao	shao@med.miami.edu	Loss of Sirt3 induced by HIV gp120 with morphine in neuropathic pain, is mediated by H3K27me3 in the spinal cord
11	Emily	Hartwell	Emily.Hartwell@pennmedicine.upenn.edu	Performance of a polygenic risk score for depression in a deeply phenotyped sample
12	Ying	He	yhe@midwestern.edu	Epigenetic regulation of opioid dependence by microRNAs
13	Elaine	Hebda-Bauer	hebda@med.umich.edu	Bioenergetic-Related Gene Expression in the Hippocampus Predicts Internalizing vs. Externalizing Behavior in a F2 Cross of Selectively-Bred Rats
14	Ming-Fen	Ho	ho.mingfen@mayo.edu	Epigenetic Regulation of GABA Catabolism in iPSC-derived Neurons: the Role of FGF21
15	Leanne	Holt	leanne.holt@mssm.edu	Elucidation of the astrocyte-specific transcriptome following cocaine self-administration
16	Spencer	Huggett	shuggett91@gmail.com	In Silico Genetic & Neuromolecular Drug Repurposing for Opioid Use Disorder
17	Alvin	Jeffery	alvin.d.jeffery@vanderbilt.edu	Detecting Opioid Use Disorders in the Electronic Health Record to Support Genetic Studies: Adaptation of the Addiction Behaviors Checklist
18	Thomas	Jhou	jhou@musc.edu	Heritability and GWAS analyses of punishment sensitivity and cocaine avoidance in HS rats
19	Kan	Shao	kshao@indiana.edu	Dose-Response Analysis to Advance Gene and Pathway Identification for Risk Estimation of Substance Use Disorder
20	Guochun	Jiang	jianggc@gmail.com	Epigenetic regulation of a persistent HIV reservoir in human brain myeloid cells despite durable ART
21	Emma	Johnson	emma.c.johnson@wustl.edu	Cross-disorder analysis of cannabis use disorder and schizophrenia reveals convergent and divergent genetic influences
22	Yonwoo	Jung	yonwoo.jung@nih.gov	Mitochondrial Dysfunction and Oxidative Stress: Conserved Functional Phenotypes in Cocaine Addiction across Multiple Brain Regions
23	Marcus	Kaul	Marcus.Kaul@medsch.ucr.edu	Methamphetamine promotes in macrophages stimulated with LTR mimic ssRNA40 expression of HIV-regulating lncRNA HEAL and pro-inflammatory factors but suppresses the interferon response
24	Panjun	Kim	pkim11@uthsc.edu	3D Chromatin Interaction Data Facilitates de novo Genome Assembly and Identifies Promoter-Enhancer Interaction in the PFC of Rats
25	Cassandra	Kooiker	ckooiker@uci.edu	Genetic tagging uncovers a role for the thalamic paraventricular nucleus in mediating aberrant reward behaviors following adverse experiences early in life
26	Brittany	Kuhn	kuhnb@musc.edu	Network-based clustering approach models multi-symptomatic opioid use disorder vulnerability
27	Ashley	Kumar	avkumar@ucsd.edu	Transcriptional initiation profiling of primary brain cells to study stimulus-dependent enhancer activity
28	Valeria	Lallai	vlallai@uci.edu	THC- and Nicotine-Induced Changes in Central and Peripheral Extracellular Vesicle RNA Cargo
29	Eva	Lancaster	Eva.Lancaster@vcuhealth.org	Examining polygenic risk score by environment interaction on the relationship between interpersonal violence exposure and alcohol use in an ancestrally diverse college cohort
30	Paige	Lemen	plemen1@uthsc.edu	Opiate responses are controlled by interactions of Oprm1 and Fgf12 loci in rodents: Correspondence to human GWAS findings
31	Michael	Leone	mleone@andrew.cmu.edu	Spinal cord neuronal subtypes conserved across species are genetically implicated in chronic pain disorders
32	Dongmei	Li	Dongmei_Li@urmc.rochester.edu	Longitudinal changes in expression profile of urine exosomal epigenetic microRNAs in exclusive electronic cigarette adult users
33	Xiaoyu	Liang	xiaoyuliang@msu.edu	DNA Methylation-Based Telomere Length Is Associated With HIV Frailty and All-Cause Mortality
34	Carl	Litif	clitif@uwyo.edu	Identifying reward-specific transcriptomes underlying polyreward seeking ensembles in the nucleus accumbens core and prelimbic cortex
35	Shirelle	Liu	liu00459@umn.edu	Differential gene expression and epigenetic regulation in the medial prefrontal cortex of rats showing vulnerability to opioid addiction
36	Jennifer	Loftis	loftisj@ohsu.edu	Plasma extracellular vesicles and their miRNA cargo as biosignatures for neuropsychiatric impairments in methamphetamine use disorders
37	Ryan	Logan	Ryan.Logan@umassmed.edu	Elevated DNA damage and inflammatory markers in specific striatal cell types associated with opioid use disorder using single nuclei RNAseq in human postmortem brain
38	Falk	Lohoff	falk.lohoff@nih.gov	Additive Effects of Stress and Alcohol on Epigenetic Aging
39	Samikkannu	Thangavel	thangavel@tamu.edu	Epigenetic signature of N-terminal acetyltransferases role in HIV-Neuropathogenesis

May 17 – Poster Session C (10:15 am – 11:45 am)
Poster #	First Name	Last Name	Email	Abstract Title
1	Alice	Min	Alice.Min@mountsinai.org	A novel humanized mouse model to track active and latent CNS HIV-1 infection and to test therapeutic interventions
2	Luis	Araujo	ldearaujo@unimelb.edu.au	Power, measurement error and pleiotropy robustness in twin design extensions to Mendelian randomization
3	Paige	Lemen	plemen1@uthsc.edu	Oxycodone oral self-administration in inbred rats identifies different patterns of vulnerability
4	Andrew	Lombardi	anlo5057@colorado.edu	Role of GSCAN Identified Genes in the Astrocytic Response to Nicotine
5	Shahrdad	Lotfipour	shahrdadlotfipour@me.com	Functional Role of a Human 3'UTR Alpha6 Nicotinic Receptor Polymorphism (rs2304297) in Adolescent Substance Use
6	Qing	Lu	lucienq@ufl.edu	Kernel Neural Networks for Analyzing Large-scale Substance Use Disorders Genetic Data
7	William	Lynch	wlynch@bu.edu	Validating Zhx2 in oxycodone metabolite (oxymorphone) brain concentration and behavior via reciprocal gene editing and viral manipulation of gene expression in BALB/c substrains
8	Tianzhou	Ma	tma0929@umd.edu	Bayesian indicator variable selection for multivariate response with application to multi-trait fine mapping
9	Scott	Mackey	msmackey@uvm.com	ENIGMA Addiction: Neuroimaging Biotypes Supported by Gene Enrichment Analysis
10	Rajtarun	Madangopal	rajtarun.madangopal@nih.gov	In vivo labeling and molecular characterization of cocaine memory-specific active neurons using the photo-convertible calcium integrator CaMPARI2
11	Travis	Mallard	tmallard@mgh.harvard.edu	Limited evidence for a general dimension of impulsivity across genomic, transcriptomic, and neuroanatomical levels of analysis
12	Lisa	Maturin	lmaturin@health.ucsd.edu	The Addiction Biobanks: : Three repositories of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of cocaine, oxycodone, and alcohol self-administration.
13	Nicola	Micali	nicola.micali@yale.edu	The effect of prenatal cannabinoid exposure on developing primate cerebrum
14	Melyssa	Minto	mminto@rti.org	Tissue-Specific DNA Methylation Signatures of Alcohol Use Disorder in Human Brain
15	Suzanne	Mitchell	mitchesu@ohsu.edu	Lessons learned in creating selected lines for high and low delay discounting
16	Mahesh	Mohan	mmohan@txbiomed.org	Delta-9-Tetrahydrocannabinol:Cannabidiol combination counteracts colonic epithelial and blood-brain barrier dysfunction in SIV-infected rhesus macaques on combination anti-retroviral therapy
17	Kateryna	Murlanova	kmurlano@buffalo.edu	Loss of astrocytic mu opioid receptors exacerbates aversion associated with morphine withdrawal in mice: a role for mitochondrial respiration
18	Randy	Nelson	randy.nelson@hsc.wvu.edu	Light at Night Drives Sex-Specific Increases in Fentanyl Reward-Related Behaviors
19	Abraham	Palmer	aap@ucsd.edu	RATTACA: a new paradigm for examining genetic correlations in outbred rats
20	Rohan	Palmer	Rohan.Palmer@Emory.edu	Conserved Co-expression Signatures of Chronic Alcohol Consumption across Species
21	Clarissa	Parker	cparker@middlebury.edu	Genetic variation and heritability of negative affective withdrawal from cocaine in the CC/DO founder mouse strains
22	Gita	Pathak	gita.pathak@yale.edu	Epigenetic profiles of latent classes for polysubstance use disorder
23	Jack	Pattee	jack.pattee@cuanschutz.edu	Adjusting for cis-regulatory variation in gene expression data can improve biological network analysis in model organisms
24	Qian	Peng	qpeng@scripps.edu	Pleiotropic Loci for Cannabis Use Disorder Severity in Multi-Ancestry High-Risk Populations
25	Inga	Peter	inga.peter@mssm.edu	High Content Transcriptomics Screen to Explore Pathway Crosstalk between Morphine and Antiretroviral Therapy Drug Combinations
26	Amanda	Gentry	Amanda.Gentry@vcuhealth.org	Machine Learning to Predict Alcohol Consumption From Blood-Based Biomarkers
27	Robert	Phillips	rphill3@uab.edu	Distinct subpopulations of D1 medium spiny neurons exhibit unique transcriptional responsiveness to cocaine
28	Bryan	Quach	bquach@rti.org	Transcriptome-wide association study for frequent cocaine use identifies gene dysregulation in CD4+ T cells linked to immune response and cancer pathways
29	Fatir	Qureshi	qureshi@wi.mit.edu	Chromatin QTL analysis identifies genetic variants that influence H3K27ac in opioid overdose cases.
30	Yumna	Rahman	rahmany@vcu.edu	Influence of Genotype and Sex on Oral Nicotine Consumption in Founder Strains of Diversity Outbred Mice
31	Hannah	Ramcharan	hkramcha@wi.mit.edu	Variation in Gene Regulation Across Neurons from Seven Different Brain Regions
32	David	Root	David.Root@Colorado.EDU	Ventral tegmental area glutamate neurons establish a mu-opioid receptor gated circuit to mesolimbic dopamine neurons and regulate opioid-seeking behavior
33	Adrian	Rothenfluh	adrian.rothenfluh@hsc.utah.edu	Bitter gustatory perception protects Drosophila from escalating cocaine consumption preference.
34	Erick	Saldes	esaldes@miners.utep.edu	Novel genetic loci interacting with social environment for dysfunctional inhibitory control
35	Danielle	Sambo	danielle.sambo@nih.gov	Differential effects of prenatal alcohol exposure on brain growth in a mouse model for fetal alcohol spectrum disorder
36	Yasmine	Sami	yns@wi.mit.edu	Differentially expressed genes in Opioid Use Disorder are enriched amongst genes with brain region specific regulatory activity
37	Jiangwen	Sun	jsun@odu.edu	Training Deep Neural Networks Predicting DNA Methylation to Elucidate Genetic Associations in Substance Use Disorders

May 17 – Poster Session D (2:30 pm – 4:00 pm)
Poster #	First Name	Last Name	Email	Abstract Title
1	Sandra	Sanchez-Roige	sanchezroige@ucsd.edu	Multi-ancestry meta-analysis of tobacco use disorder based on electronic health record data prioritizes novel candidate risk genes and reveals associations with numerous health outcomes
2	Pietro	Sanna	psanna@scripps.edu	Unraveling the interplay between neuroHIV and substance abuse with systems biology to shed light on novel druggable targets.
3	Katherine	Savell	katherine.savell@nih.gov	Development of multipleXed Population Selection and Enrichment single nuclei RNA-sequencing (XPoSE-seq) to characterize neuronal ensembles in cocaine relapse
4	Randal Alex	Serafini	alex.serafini@icahn.mssm.edu	Novel Oxycodone Paradigm Highlights Mesocorticolimbic Mechanisms Underpinning Withdrawal-associated Behaviors with and without Chronic Pain
5	Marit	Solheim-Witt	marit@alpha-element.com	Resilience, resourcefulness and self-leadership: Evaluation of a self-management program and novel conceptual framework of Vitality Type patterns in behavior and communication
6	Akhil	Sharma	akhilsharma@wayne.edu	Comparing Responses of the Nucleus Accumbens and Ammon’s Horn to Methamphetamine Neurotoxicity
7	Aliaksandra	Sikirzhytskaya	sikirzha@mailbox.sc.edu	AI-based mining of biomedical literature: Applications for the drug repurposing for the treatment of HIV-Associated Neurocognitive Disorder.
8	Omar	Soler-Cedeño	omar.soler-cedeno@nih.gov	Brain CB2 receptor: a new therapeutic target for treating opioid use disorders, major findings from a new CB2-KO-eGFP reporter mouse line
9	Sheetal	Sreeram	sxs2286@case.edu	Induced pluripotent stem cells (iPSCs) derived cerebral organoids to model the impact of methamphetamine exposure on HIV latency.
10	Chaitanya	Srinivasan	csriniv1@cs.cmu.edu	Regulatory variation in D1/D2 co-expressing medium spiny neurons is suggested to predispose addiction-related traits
11	Jerry	Stitzel	stitzel@colorado.edu	QTL Mapping of Genetic Modifiers of Oral Nicotine Consumption in Chrna5 Null Mutant Mice
12	Kyle	Sullivan	sullivanka@ornl.gov	Heroin overdose-associated transcriptional and epigenetic alterations in the orbitofrontal cortex concentrate in GABAergic interneurons and provide insight into cell type-specific regulatory response
13	Jiangwen	Sun	jsun@odu.edu	Annotating Genetic Variants by Training Deep Neural Networks to Predict Multiple Epigenomic Events in Brain via Effective Multi-task Learning
14	Makoto	Taniguchi	Taniguch@musc.edu	A long non-coding enhancer RNA regulates NPAS4 in the NAc to control drug reward-conditioned behavior
15	Lisa	Tarantino	lisat@med.unc.edu	Genetic mapping of initial locomotor sensitivity to cocaine in two divergent Collaborative Cross inbred mouse strains
16	Iris	Titos	iris.titos@utah.edu	Mechanisms of diet modulating experience-dependent amphetamine preference
17	Jill	Turner	Jill.Turner@uky.edu	Phenotyping Individual Differences in Escalation of Fentanyl Self-Administration in Sprague-Dawley Rats.
18	David	Vandenbergh	djv4@psu.edu	Hyper-Variable Number of Tandem Repeats in Intron 8 of the Human Dopamine Transporter Gene (SLC6A3)
19	Arvind	Venkataraman	avenkata@uw.edu	A genome-wide association study of methamphetamine use among people with HIV
20	Thiago	Viola	thiago.wendt.viola@gmail.com	The effects of maternal cocaine use during pregnancy in pediatric epigenetic clocks and methylation risk scores in humans
21	Lu	Wang	lu.wang.lw763@yale.edu	Whole-exome Sequencing Study of Alcohol Use Disorder in 1,668 European Americans and 1,547 African Americans
22	Xu	Wang	xuwang@temple.edu	Activation of Toll-like receptor 3 by poly (I:C) inhibits HIV infection of human iPSC-derived microglia
23	Tao	Wu	Tao.Wu@bcm.edu	Quantitative Profiling of DNA N6-methyladenine at single-base resolution with NAME-Seq
24	Sarah	Neal	sjneal@mdanderson.org	A Baboon Research Resource for Use in Studies on Substance Abuse Disorders
25	Julie	White	jdwhite@rti.org	Integration of DNA methylation and RNA sequencing elucidates differential gene regulation associated with alcohol use disorder in the human brain
26	Anastasia	Williams	awill57@gmu.edu	The effects of cannabidiol and HU308 on viral transcription in HIV-1 infected cells and resulting extracellular vesicle release
27	Caryn	Willis	cdwillis@rti.org	Gene Correlation Networks Replication Analysis Across Studies to Identify Top Candidate Gene Targets in Opioid Use Disorder
28	Michael	Wyatt	wyatt@cop.sc.edu	Drug Repurposing for the prevention of dementia among people living with human immunodeficiency virus: A focus on the renin-angiotensin system
29	Rong-Guang	Xu	roxu@bwh.harvard.edu	How histone post-translational modifications impact nucleosome structure and accessibility: A molecular dynamics study
30	Gal	Yadid	yadidg@mail.biu.ac.il	Use of psychedelic and epigenetic substances as novel approaches for treating substance addiction – hope or hype?
31	Zhenyao	Ye	zye@som.umaryland.edu	Pleiotropic genes for resting-state brain functional connectivity and nicotine addiction
32	Hang	Zhou	hang.zhou@yale.edu	Mendelian Randomization Analysis of the Effects of Alcohol Use on Cancer Risk
33	Yanjiao	Zhou	yazhou@uchc.edu	Genetic control of the microbiome and bile acids to influence addiction-related behaviors
34	Laura	Hack	hack@stanford.edu	Ketamine’s Acute Effects on Negative Brain States are Mediated through Distinct Altered States in Humans
35	Yanchao	Pan	hanyou@umich.edu	A revamped rat reference genome improves the discovery of genetic diversity of laboratory rats

Abstracts From Those Unavailable to Present
First Name	Last Name	Email	Abstract Title
Li-Shiun	Chen	li-shiun@wustl.edu	Roadmap for translating genomic evidence to clinical interventions for prevention and treatment
Ditte	Demontis	ditte@biomed.au.dk	Elucidating genetic risk factors for externalizing and internalizing alcohol use disorder behaviors through large-scale cross-disorder GWAS
Desmond	Smith	DSmith@mednet.ucla.edu	Cocaine and cannabis: a joint dependence revealed by a longitudinal genetic study in mice

Abstracts and Agenda from April/May 2022 meeting

Agenda (PDF, 177KB)

Presentations

April 27^th- Session 1 (11 am - 12:30 pm) Data Science in HBCUs: Leveraging Scientific Expertise to Tackle the Genetics of Addiction
Time	Name and Email	Abstract
11:00	William Southerland	The Howard University Center of Applied Data Science and Analytics (CADSA)
11:15	Anil Shanker	Genomics and Health Equity Research: Current Challenges and Opportunities
11:30	Jennifer Troyer	Human Heredity and Health in Africa (H3Africa)
11:45	Adaku Ofoegbu	The Role of Phase II Metabolic Enzymes and Drug Transporters on Buprenorphine Pharmacogenomics in Opioid Use Disorder Management
12:00	Evaristus Nwulia	Comparative Response to Alcohol in Individuals with ADH1B1 and ADH1B3 Polymorphisms

April 27^th- Session 2 (1 pm - 2:30 pm)Tools and Methods to Visualize Genomic Signals in GWAS
Time	Name and Email	Abstract
1:00	Xiaoyu Liang	A Mediating Role for Epigenetic Aging in the Relationship Between People Who Inject Drugs with HCV and All-Cause Mortality
1:15	Luis Castro-de-Araujo	Bidirectional causal modeling with instrumental variables and data from relatives
1:30	Brittany Kuhn	Network-based clustering approach models multi-symptomatic opioid use disorder vulnerability
1:45	Kyle Sullivan	Multi-omic network analysis identifies key neurobiological pathways in opioid addiction
2:00	Andy Chen	Functional Screening of 3’-UTR Variants Combined with Genome-wide Association Identifies Causal Regulatory Mechanisms Impacting Alcohol Consumption and Alcohol Use Disorder

May 4^th- Session 3 (11 am - 12 noon)Can Increasing Diversity Lead to Deeper Understanding of Addiction?
Time	Name and Email	Abstract
11:00	Xingyan Wang	Trans-Ancestry Fine-Mapping and Ancestry Heterogeneity Analysis for Smoking & Drinking Addiction Phenotypes using 3.4 Million Individuals with Diverse Ancestries
11:15	Alexia Hatoum	Cross-Ancestral Genome-wide analysis of Broad Addiction Vulnerability Leads to Additional Insight Over European GWAS Alone
11:30	Hang Zhou	Advanced genetic study of problematic alcohol use in > 1 million subjects from multiple populations

May 4^th - Session 4 (12:30 pm - 2 pm)Leveraging Multi-Species Analyses
Time	Name and Email	Abstract
12:30	Andreas Pfenning	What can bats, capybaras, and tree shrews tell us about the genetic basis of addiction?
12:45	Brenda Cabrera-Mendoza	Cross-tissue Evaluation of Epigenetic Clocks in Substance Use Disorder
1:00	Abraham Palmer	Comparing polygenic signals across species
1:15	Rohan Palmer	Molecular Brain Signatures of Chronic Alcohol Use Across Species
1:30	Robyn Ball	Integrating past, present and future mouse and human population genetics of addiction using multi-trait meta-analyses to identify conserved human polysubstance use genes

May 4^th- Session 5 (2 pm - 3 pm)Understanding Comorbidities and Addiction
Time	Name and Email	Abstract
2:00	Bonnie Alberry	Sex-specific prefrontal cortex gene networks moderate the effect of early adversity on childhood behavior and adult substance abuse
2:15	Amelia Cuarenta	The effect of resource scarcity early in life on the rat basolateral amygdala transcriptome
2:30	Ditte Demontis	Genome-wide cross-disorder analysis of ADHD and cannabis use disorder and cannabis use

May 11^th- Session 6 (11:15 am - 12:30 pm)Epigenetics, Gene Regulation and the SUD Brain
Time	Name and Email	Abstract
11:15	Consuelo Walss-Bass	Postmortem brain multi-omic profiling and vertical data integration in cocaine and opioid use disorder
11:30	Jessica Childs	Dominant negative of transcription factor NR4A2 in medial habenula attenuates reinstatement of cocaine self-administration in mice
11:45	Delaney Fischer	Investigating the transcriptomic and epigenomic profile of the mouse striatum following cocaine exposure
12:00	Erin Calipari	Histone acetyltransferase KAT2A is a critical epigenetic regulator of cocaine responses in the nucleus accumbens

May 11^th- Session 7 (1 pm - 2:15 pm)The Power of Single Cell Studies
Time	Name and Email	Abstract
1:00	Zhuzhu Zhang	Single-cell characterization of epigenomic remodeling in cocaine self-administration in mice
1:15	Ming-Fen Ho	Single cell transcriptomics reveals distinct transcriptional response to oxycodone and buprenorphine by iPSC-derived brain organoids from patients with opioid use disorder
1:30	Jessica Zhou	Computational analysis of snATAC-seq from amygdalae reveals cell type-specific chromatin regions associated with cocaine addiction
1:45	BaDoi Phan	Single cell multi-omics of the rhesus macaque striatum reveal regulatory mechanisms underlying the genetic basis of addiction

Posters

April 27^th - Poster Session A (3 pm to 4:15 pm)
Poster #	Name and Email	Abstract
1	William Southerland	The Howard University Center of Applied Data Science and Analytics (CADSA)
2	Anil Shanker	Genomics and Health Equity Research: Current Challenges and Opportunities
3	Jennifer Troyer	Human Heredity and Health in Africa (H3Africa)
4	Andy Chen	Functional Screening of 3’-UTR Variants Combined with Genome-wide Association Identifies Causal Regulatory Mechanisms Impacting Alcohol Consumption and Alcohol Use Disorder
5	Brenda Cabrera-Mendoza	Cross-tissue Evaluation of Epigenetic Clocks in Substance Use Disorder
6	Robyn Ball	Integrating past, present and future mouse and human population genetics of addiction using multi-trait meta-analyses to identify conserved human polysubstance use genes
7	Bonnie Alberry	Sex-specific prefrontal cortex gene networks moderate the effect of early adversity on childhood behavior and adult substance abuse
8	Soren Emerson	A history of cocaine self-administration and withdrawal reprograms the transcriptional response to acute cocaine in the NaC
9	Lauren Bailey	Orbitofrontal And Accumbal Dopamine Function In Bxd Mouse Strains Selected For High Or Low Impulsivity
10	Collin Teague	Circuit-wide gene network analysis reveals a role for phosphodiesterase enzymes in cocaine addiction
11	Ashita Batra	Polygenic Risk for High Fasting Insulin Predicts Childhood Impulsivity and Adulthood Substance Dependence in Response to Early Adversity
12	Jacob Beierle	A BALB/c reduced complexity cross identifies Zhx2 as a candidate gene underlying oxymorphone brain concentration and state-dependent learning of oxycodone reward
13	Andrew Bergen	Predicted Nicotine Biomarkers and Translational Research in Multiethnic Populations
14	Rigel Mahmood	Dimension Reduction and Cluster Analysis of Mouse Microbiome Data for Understanding Heterogeneity of Addiction
15	Kasey Brida	Reelin protein marks cocaine-sensitive Drd1+ medium spiny neurons and modulates the transcriptional and physiological response to dopamine
16	Emily Brocato	Adolescent Binge Ethanol Induces Dysregulation of H3K36me3 at Dendritic Spine, Synaptic Assembly, and Memory-related Genes
17	Caleb Browne	Transcriptome profiling of the brain’s reward circuitry in heroin self-administration identifies a ventral hippocampus gene network related to relapse susceptibility
18	Jason Bubier	A tale of two opioids: The genetics of fentanyl and morphine lethality in mice
19	Katerina Zorina-Lichenwalter	Common factors across chronic pain conditions in the UK Biobank
20	Cali Calarco	Mitochondrial gene ontology pathways and transcriptional regulators impacted by cocaine self-administration in C57Bl/6 mice
21	Poster Presenter Unavailable
22	Rianne Campbell	Molecular Profiling of Mouse Ventral Pallidum Projection Neurons
23	Nazzareno Cannella	NIH Heterogeneous Stock rats trained to heroin self-administration show heterogeneous response to the anti-addictive effects of the MOP/NOP agonist Cebranopadol
24	Megan Carnes	Smoking-informed methylation QTLs in human nucleus accumbens
25	Subhash Chand	Role of Methamphetamine Induced Extracellular Vesicles in HIV Neuropathogenesis and Toxicity

April 27^th - Poster Session B (4:15 pm to 5:30 pm)
Poster #	Name and Email	Abstract
26	Li-Shiun Chen	Precision Tobacco Treatment: Genetic risk scores and biomarkers
27	Alexia Hatoum	Cross-Ancestral Genome-wide analysis of Broad Addiction Vulnerability Leads to Additional Insight Over European GWAS Alone
28	Amelia Cuarenta	The effect of resource scarcity early in life on the rat basolateral amygdala transcriptome
29	Ditte Demontis	Genome-wide cross-disorder analysis of ADHD and cannabis use disorder and cannabis use
30	Consuelo Walss-Bass	Postmortem brain multi-omic profiling and vertical data integration in cocaine and opioid use disorder
31	Jessica Childs	Dominant negative of transcription factor NR4A2 in medial habenula attenuates reinstatement of cocaine self-administration in mice
32	Delaney Fischer	Investigating the transcriptomic and epigenomic profile of the mouse striatum following cocaine exposure
33	Youshu Cheng	Genetic variants influence DNA methylation on Cocaine Use in the Veterans Aging Study Cohort
34	Eric Choi	Cell Subtype Specific Role of Nab2 in Cocaine Seeking Behavior
35	Richard Crist	Single nucleus transcriptomic analysis of the nucleus accumbens reveals distinct cell type-specific patterns of gene expression associated with the escalation of morphine intake in male rats
36	Renata Cupertino	Neural Correlates of Polygenic Risk Scores for Problematic Substance Use in Adolescents
37	Poster Presenter Unavailable
38	Tristan de Jong	Genetic variation within 90 inbred rat strains mapped to mRatBN7.2
39	Eamonn Duffy	Characterization of oxycodone use disorder phenotypes in select rat strains of the Hybrid Rat Diversity Panel
40	Kit Elam	Polygenic Predisposition for Educational Attainment Predicts Self and Partner Education Attainment and Alcohol Use Frequency
41	Zachary Even	Genome-Wide Analysis of Methylome in the Mouse Brain Reveals Epigenetic Regulation of Alcohol Use Disorder
42	Fang Fang	Epigenome-wide association meta-analysis of DNA methylation with lifetime cannabis use
43	Zhouqing Fang	Graph Neural Network for Genetic Discovery from Genome Wide Association Studies
44	Poster Presenter Unavailable
45	Michael Garvin	The Missing Heritability of Complex Disorders: Structural Variants Hiding in Plain Site
46	Eric Braverman	The consequences of the sins of thy parents: multi-generational neurogenetic and epigenetic impacts on reward dysregulation and cognitive impairments require cost-effective standard Brain Health Check (BHC)
47	Hongsheng Gui	Demographics and genetic epidemiology of opioid use disorder in national-wide population-based biobanking cohorts
48	Kyung-An Han	Social context impacts inhibitory control
49	Jeffrey Hatfield	Genetic Variation in Cocaine Preference in the Drosophila melanogaster Genetic Reference Panel.
50	Elaine Hebda-Bauer	Transcriptional Profiling of the Hippocampus in an F2 Cross of a Genetic Rat Model of Internalizing vs. Externalizing Behavior and Addiction Liability

May 4^th - Poster Session C ( 3 pm to 4:15 pm)
Poster #	Name and Email	Abstract
51	Robert Hitzemann	On the Alignment of Gene Expression with Delay Discounting (DD) in Heterogeneous Stock (HS) Rats
52	Will Lynch	Oxycodone behaviors in Cacna1h knockout mice
53	Xiaoyu Liang	A Mediating Role for Epigenetic Aging in the Relationship Between People Who Inject Drugs with HCV and All-Cause Mortality
54	Luis Castro-de-Araujo	Bidirectional causal modeling with instrumental variables and data from relatives
55	Brittany Kuhn	Network-based clustering approach models multi-symptomatic opioid use disorder vulnerability
56	Ming-Fen Ho	Single cell transcriptomics reveals distinct transcriptional response to oxycodone and buprenorphine by iPSC-derived brain organoids from patients with opioid use disorder
57	Emma Johnson	Associations between polygenic liability for schizophrenia and cannabis-induced experiences
58	Jermaine Jones	Heroin Use Severity is not Associated with Telomere Length in Individuals with Opioid Use Disorder of African Ancestry
59	Radka Kaneva	Genetic Correlates of Impulsivity in Bulgarian Substance Users
60	Fatah Kashanchi	Cannabinoids reduce extracellular vesicle release from HIV-1 infected myeloid cells and inhibit viral transcription
61	Marcus Kaul	Multiple long-term changes of neurotransmission-related gene expression correlate with behavioral impairment caused by methamphetamine and NeuroHIV
62	Panjun Kim	De novo genome assembly for HXB/BXH recombinant inbred strains using Hi-C data
63	Drew Kiraly	The gut microbiome as a critical regulator of fentanyl seeking an proteomic regulation in the nucleus accumbens
64	Deniz Koyuncu	Missing Value Knockoffs for Genome-Wide Association Studies
65	Dongbing Lai	Polygenic risk scores analysis of alcohol use disorder
66	Hwuyoung Lee	Modeling Multivariate Age-related Brain Imaging Variables with Dependence: an application to assess the smoking effects on white matter tracts during brain aging
67	Paige Lemen	Social Isolation in Adolescence Leads to an Increased Resilience to the Risk of Opioid Abuse in Adulthood in Rats
68	Gabriel Odom	Detecting Regions of Concurrent and Differential Methylation with coMethDMR
69	Shuangying Leng	Oral oxycodone self-administration induces long-lasting increases in body temperature in rats
70	Rudong Li	Investigating genetic inheritability of RNA alternative splicing in alcohol use disorders
71	Mingkuan Lin	Gene expression regulation for persons with HIV who inject drugs
72	Sanxiong Liu	The interplay between AUTS2-/FBRSL1-ncPRC1.3 in transcriptional regulation and brain development
73	Shirelle Liu	Relating individual differences in vulnerability to morphine self-administration in rats to gene expression in the medial prefrontal cortex (mPFC)
74	Falk Lohoff	Epigenome-wide association study of alcohol consumption in N=8161 individuals and relevance to alcohol use disorder pathophysiology
75	Qing Lu	Functional Neural Networks for High-dimensional Genetic Data Analysis

May 4^th - Poster Session D ( 4:15 pm to 5:30 pm)
Poster #	Name and Email	Abstract
76	Robert Hitzemann	Identification of modifiers of MA intake in the presence of the high risk Taar1m1J/m1J genotype
77	Jose Martinez-Magana	The prefrontal cortex transcriptomic landscape of the interaction between post-traumatic stress disorder and opioid misuse
78	Benpeng Miao	Methamphetamine induced regional-specific transcriptomic and epigenetic changes in rat brain
79	Adaku Ofoegbu	The Role of Phase II Metabolic Enzymes and Drug Transporters on Buprenorphine Pharmacogenomics in Opioid Use Disorder Management
80	Evaristus Nwulia	Comparative Response to Alcohol in Individuals with ADH1B1 and ADH1B3 Polymorphisms
81	Andreas Pfenning	What can bats, capybaras, and tree shrews tell us about the genetic basis of addiction?
82	Abraham Palmer	Comparing polygenic signals across species
83	Rohan Palmer	Molecular Brain Signatures Of Chronic Alcohol Use Across Species
84	BaDoi Phan	Single cell multi-omics of the rhesus macaque striatum reveal regulatory mechanisms underlying the genetic basis of addiction
85	Michael Miles	Behavioral And Expression Genetics Identification Of Genes Modulating Progressive Ethanol Consumption In Diversity Outbred Mice
86	Chen Mo	The causal effect of tobacco smoking on white matter brain aging by Mendelian randomization analysis on UK Biobank participants
87	Sage Morison	Identification and manipulation of dopamine neurons recruited by fentanyl self-administration
88	Joe Nadeau	Phenotypic plasticity, the missing dimension of phenotypic variation and disease risk
89	Nghi Nguyen	Crisis in the NICU and the Medley with Midazolam
90	Jaclyn Noshay	Heroin abuse-associated transcriptional and epigenetic alterations in the orbitofrontal cortex concentrate in GABA interneurons and provide insight into potential sex-specific regulatory response
91	Yaira Nunez	Researching longitudinal changes in polysubstance use and abuse: Recontacting participants during COVID-19 pandemic
92	Steve Oghumu	Sex differences in susceptibility to addiction: Role for X chromosome inactivation?
93	Ashley Olson	Discovery of gene co-expression networks associated with cocaine-related behaviors in Collaborative Cross mice
94	Jimmy Olusakin	Transcriptomic adaptations in emotional and sensory brain nuclei in perinatal fentanyl exposed rodents
95	Tony Pan	Single-cell analysis reveals shared and distinct immune response and metabolism between SARS-CoV-2 and HIV-1 infections
96	Gary Peltz	Ondansetron Reduces Neonatal Opioid Withdrawal Severity: A Randomized Clinical Trial
97	Roseann Peterson	Investigating causal influences on alcohol consumption and major depression across middle and late adulthood – A genetically informative pseudo-longitudinal approach
98	Robert Philibert	The Dual Utility of Cg05575921 Methylation in Lung Cancer Screening Decision Making: The Value of Racial and Gender Bias Free Precision Epigenetics Approaches in Guiding Low Dose Computerized Tomography (LDCT) Use and Smoking Cessation.
99	Mudit Tyagi	Cocaine sensitizes the CD4+ T-cells for HIV infection by co-stimulating NF-kb, NFAT, and AP-1
100	Amara Plaza-Jennings	Altered microglial genome structure and transcription in HIVE impact HIV integration

May 11^th - Poster Session E ( 2:30 pm to 3:45 pm)
Poster #	Name and Email	Abstract
101	Lakmini Premadasa	Long-term delta-9-tetrahydrocannabinol administration promotes lncRNA MMP25-AS1-MMP25 mRNA interactions to preserve intestinal epithelial barrier function in chronic HIV/SIV infection
102	Bryan Quach	Transcriptome-wide association analyses identify genes associated with HIV latent reservoir and cocaine abuse
103	Alexia Ramsey	Emerging evidence of behavior change associated with fully-remote delivery of a genetically-informed smoking cessation intervention
104	Nathaniel Robinson	Transcription factor 4 coordinates gene expression and dopamine responses in the nucleus accumbens
105	Kyle Sullivan	Multi-omic network analysis identifies key neurobiological pathways in opioid addiction
106	Laura Saba	Quantitative multi-organ transcriptome in the Hybrid Rat Diversity Panel: A resource for systems genetics studies of substance use disorders
107	Sandra Sanchez-Roige	Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry
108	Michael Saul	Common genetic and genomic underpinnings of learned and unlearned addiction-related behaviors
109	Katherine Savell	Molecular characterization of cocaine-seeking engram neurons in the infralimbic cortex using single nuclei RNA-sequencing in rats
110	Souvik Seal	Rapid Condition adaptive Fused Graphical Lasso
111	Laurel Seemiller	Strain-dependent contextual fear learning outcomes after acute adolescent ethanol exposure: Examining the role of the dorsal hippocampal transcriptome
112	Anna Moszczynska	Methamphetamine Neurotoxicity Does Not Contribute to Methamphetamine Use Disorder in Parkin Knockout Rats
113	Michael Sheldon	The NIDA, ABCD, COGA and NESARC Biobanks: Sampled Provides a Critical Resource for Research into the Genetics and Epigenetics of Substance Abuse in Humans
114	Zhouyue Shi	The role of m6A RNA methylation in maintaining cell type specific functions in the basal ganglia
115	Madhurbain Singh	Cross-Lagged Mendelian Randomization: Integrating Genomic Data with Repeated-Measures Designs to Strengthen Causal Inference
116	Srah Swinford-Jackson	Epigenetic mechanisms underlying susceptibility to methamphetamine self-administration in methamphetamine-sired male rats
117	Yalun Tan	Neuron Navigator 1 (Nav1) Regulates Learning, Memory and the Response to Multiple Drugs of Abuse (DOA)
118	Stephanie Caligiuri	Brain-body chemosensing regulates the addictive properties of nicotine
119	Francesca Telese	Single-cell transcriptomics reveals that reduced glucose metabolism is linked to addiction-like behavior in rats
120	Samikkannu Thangavel	HIV-1 Tat and Cocaine Impact the LIN01133-hsa-miR-4726-5p - NDUFA9 axis to Modulate Astrocyte Energy Metabolism
121	Iris Titos	Molecular pathways regulating sleep and SUD
122	Dong-Binh Tran	Closing the loop on Turicibacter

May 11^th - Poster Session F ( 3:45 pm to 5 pm
Poster #	Name and Email	Abstract
123	Xingyan Wang	Trans-Ancestry Fine-Mapping and Ancestry Heterogeneity Analysis for Smoking & Drinking Addiction Phenotypes using 3.4 Million Individuals with Diverse Ancestries
124	Hang Zhou	Advanced genetic study of problematic alcohol use in > 1 million subjects from multiple populations
125	Zhuzhu Zhang	Single-cell characterization of epigenomic remodeling in cocaine self-administration in mice
126	Jessica Zhou	Computational analysis of snATAC-seq from amygdalae reveals cell type-specific chromatin regions associated with cocaine addiction
127	Makeda Turner	Epigenome editing of nucleus accumbens cell subtype transcripts regulated by fentanyl abstinence
128	Avanish Veerappa	A multipronged approach unravels the spectrum of variants and transcriptomic signatures in distinct stages of substance use and addiction
129	Paige Lemen	Morphine and Naloxone Responses are controlled by Oprm1 and Fgf12 loci in the murine BXD family: Epistasis and time-dependent locomotor interaction effects
130	Qun Wang	Targeting Delivery of Therapeutic Vaccines to Treat HIV People Who Use Drugs
131	Robert Williams	A Multiomic Genetic Resource for Analysis of Gene Function and SUD in the Rat CNS
132	Christina Woo	Intracellular protein targets of the opioids
133	Lisa Wu	Mimicking concurrent viral infection and substance abuse in a cell culture model
134	Kuranosuke Yamada	Mapping and Analyses of Differential Co-expression Networks of Striatum Tissue in Cocaine-treated, high-diversity mouse populations
135	Fengchun Ye	Role of nuclear receptors in epigenetic silencing of HIV in microglia and neuroprotection following methamphetamine exposure
136	Zhenyao Ye	Meta-analysis of transcriptome-wide association studies across 13 brain tissues identified novel clusters of genes associated with nicotine addiction
137	Pengyue Zhang	Network medicine and electronic health record-based discovery of repurposable drugs for neonatal opioid withdrawal syndrome (NOWS)
138	Shuping Zhong	Deficiency in key transcription factor Brf1 of RNA Pol III genes results in protein synthesis obstacle and phenotypic alteration
139	Nathan Gaddis	Association of Polygenic Risk Scores with the Need for Pharmacologic Treatment of Neonatal Abstinence Syndrome: Results from a Genome Wide Association Study
140	Rhea Sullivan	miRNAs that regulate neurodevelopment also respond to opioid withdrawal in neonatal opioid withdrawal syndrome (NOWS) infant saliva
141	Peter Barr	Predicting Substance Use Disorders: A Multifactorial Risk Index Combining Clinical, Environmental, and Genetic Risk Factors

Abstracts and Agenda from March 2021 meeting

Agenda (PDF, 647KB)

Name and Email	Abstract	Poster Session	Talk Session	Slack link
Kerry J. Ressler	From SNPs and Stress to SUDs: Genetics and Epigenetic mediators of Social Determinants of Health, PTSD, and Substance Use Disorders	Wednesday 2:00 to 3:00	Monday 11:00 AM	Kerry-ressler
Christopher Guevara	Parkinson’s disease gene mutation perturbs behavioral and synaptic adaptions to social defeat stress	Monday 4:00 to 5:00	Monday 11:15 AM	Guevara
Jean Lud Cadet	Increased cannabinoid receptor expression in the hippocampus drives abstinence from compulsive methamphetamine taking	Monday 2:00 to 3:00	Monday 11:30 AM	Cadet-Jean-Lud
Shareefa Dalvie	Genomic influences on self-reported childhood maltreatment	Monday 3:00 to 4:00	Monday 11:45 AM	Dalvie
Randall J. Ellis	Genomic prediction of alcohol and opioid use disorders using machine learning	Monday 4:00 to 5:00	Monday 1:00 PM	Ellis
Seon-Kyeong Jang	Rare variant heritability of tobacco use: Evidence from deep whole-genome sequencing of up to 26,000 individuals	Tuesday 2:00 to 3:00	Monday 1:20 PM	Jang
Daniel Jacobson	Embracing Complexity: Supercomputing Enabled Systems Biology to Understand Complex Neurosystems	Tuesday 2:00 to 3:00	Monday 1:40 PM	Jacobson
Rohan Palmer	Computational Drug Discovery for Cocaine and Opioid Use Disorders	Wednesday 2:00 to 3:00	Tuesday 11:00 AM	Palmer
Brock Grill	Genetic behavioral screen identifies an orphan anti-opioid system	Monday 4:00 to 5:00	Tuesday 11:15 AM	brock-grill
Vivek Kumar	Discovery of novel, addiction-relevant genes through endophenotype modelling of Knockout Mouse Project (KOMP) data	Tuesday 3:00 to 4:00	Tuesday 11:30 AM	Kumar
Michelle L. Hastings	Antisense Oligonucleotide Approaches to the Treatment of Disease	Monday 4:00 to 5:00	Tuesday 11:45 AM	Michelle-hastings
Christiann Gaines	Assessing the impact of compositionally distinct gut microbiotas on differences in initial cocaine sensitivity in closely related inbred mouse substrains	Monday 4:00 to 5:00	Tuesday 1:00 PM	Gaines
Sierra Simpson	Drugs, Bugs, and SUDs: Leveraging the Microbiome and Metabolome to Predict Addiction Liability	Wednesday 3:00 to 4:00	Tuesday 1:20 PM	Simpson
Drew Kiraly	Manipulations of gut microbiome diversity alter cocaine seeking behavior and striatal gene expression	Tuesday 2:00 to 3:00	Tuesday 1:40 PM	kiraly-d
Alexander Urban	Technically challenging types of genome sequence variants with relevance to brain function, and new approaches to their analysis	Wednesday 3:00 to 4:00	Wednesday 11:00 AM	Urban
Melissa Gymrek	The impact of short tandem repeats on complex traits	Monday 4:00 to 5:00	Wednesday 11:15 AM	Gymrek
Avindra Nath	Epigenetic regulation of retroviruses in embryogenesis, oncogenesis and neurodegeneration	Tuesday 4:00 to 5:00	Wednesday 11:30 AM	Nath
Sandhya Chandrasekaran	Neuron-specific regulation of chromosomal megadomains in the mammalian brain implicated in endogenous retroviral silencing	Monday 3:00 to 4:00	Wednesday 11:45 AM	Chandrasekaran
Jimmy Olusakin	Transcriptomic adaptations in emotional and sensory brain nuclei in perinatal fentanyl exposed rodents	Tuesday 4:00 to 5:00	Wednesday 4:00 PM	Olusakin
Marta Pratelli	Drugs of abuse drive activity producing changes in gene expression that switch neurotransmitters and behaviors	Wednesday 2:00 to 3:00	Wednesday 4:20 PM	Pratelli
Jian Feng	Neuron-specific role of methylated DNA cytosine dioxygenase TET1 in cocaine addiction	Monday 4:00 to 5:00	Wednesday 4:40 PM	Feng
Arpana Agrawal	An Update from the Psychiatric Genomics Consortium’s Substance Use Disorder Working Group (PGC-SUD)	Monday 2:00 to 3:00		Agrawal
Carter Allen	A statistical framework for network-based discovery of opioid use sub-populations in rats using the Bayesian stochastic block model	Monday 2:00 to 3:00		Allen
Robert Anholt	The Drosophila Brain on Cocaine at Single Cell Resolution	Monday 2:00 to 3:00		Anholt
Brad Aouizerat	Frequent Cocaine Use is Associated with Larger HIV Reservoir Size Quantified by the Intact Proviral DNA Assay	Monday 2:00 to 3:00		Aouizerat
Jared Bagley	Impulsivity Phenotypes are Linked with Novel Genetic Loci in Diversity Outbred Mice	Monday 2:00 to 3:00		Bagley
Brandon Baker	Dissecting the Genetic Basis of Variation in Cocaine and Methamphetamine Consumption in Outbred Populations of Drosophila melanogaster	Monday 2:00 to 3:00		Baker
Amanda Barkley-Levenson	Validating novel human GWAS hits for problematic alcohol use and consumption using genetic mouse models	Monday 2:00 to 3:00		Barkley-Levenson
Peter Barr	Identifying Shared and Specific Genetic Risks for Substance Use Disorders	Monday 2:00 to 3:00		Barr
Amelie Baud	Investigating the gut-brain axis in 4,006 P50 Heterogeneous Stock rats	Monday 2:00 to 3:00		Baud
Yudhishtar Bedi	Paternal Alcohol Exposure Leads To Altered Sperm Epigenome And Fetal Growth Restriction	Monday 2:00 to 3:00		Bedi
Jacob Beierle	BALB/c substrain differences in whole brain concentrations of the highly potent oxycodone metabolite, oxymorphone map to chromosomes 5, 10, and 16 in a reduced complexity cross	Monday 2:00 to 3:00		Beierle
Andrew Bergen	Multiethnic Prediction of Nicotine Biomarkers and Associations with Nicotine Dependence	Monday 2:00 to 3:00		Bergen
Laura Bierut	When will we be ready to bring polygenic risk scores into clinical medicine?	Monday 2:00 to 3:00		Bierut
Molly Bogue	Mouse Phenome Database: Resources and analysis tools for curated and integrated primary mouse addiction related phenotype data	Monday 2:00 to 3:00		Bogue
Heather Branscome	Retroviral Infection of Human Neurospheres and Use of Stem Cell EVs to Repair Cellular Damage	Monday 2:00 to 3:00		Branscome
Caleb Browne	Heroin self-administration and seeking induces transcriptional reprogramming throughout the brain’s reward circuitry	Monday 2:00 to 3:00		Browne
Jason Bubier	Genetic variation in opioid-induced respiratory depression	Monday 2:00 to 3:00		Bubier
James Cai	Machine Learning Analysis of Single-cell Gene Regulatory Networks Reveals Signature Transcriptional Responses in Neurons to Acute Morphine Treatment	Monday 2:00 to 3:00		Cai
Cali Calarco	Mitochondria-Related Nuclear Gene Expression in Reward Related Brain Regions and Blood Mitochondrial Copy Number after Developmental Fentanyl Exposure in Adolescent Male and Female C57BL/6 Mice	Monday 2:00 to 3:00		Calarco
Rianne Campbell	Molecular Profiling of Mouse Ventral Pallidum Projection Neurons	Monday 3:00 to 4:00		Campbell
Nazzareno Cannella	Long access heroin self-administration induces grey matter volume reduction in NIH Heterogeneous Stock rats	Monday 3:00 to 4:00		Cannella
Anjelica Cardenas	The Functional Role of a Human Polymorphism (rs2304297) in the 3’-UTR of the CHRNA6 Gene in Nicotine-Induced Locomotion and Anxiety in Adolescent Sprague Dawley Rats	Monday 3:00 to 4:00		Cardenas
Diana Carreno	Nicotine plus cue-induced reinstatement is enhanced in adolescent Sprague-Dawley rats containing the Human 3’UTR polymorphism (rs2304297) in the alpha(_)6 nicotinic acetylcholine receptor subunit	Monday 3:00 to 4:00		Carreno
Lieselot Carrette	Identification of genetic variants that contribute to compulsive cocaine intake in rats	Monday 3:00 to 4:00		Carrette
Andy Chen	Massively Parallel Reporter Assay Reveals Functional Impact of 3’-UTR SNPs Associated with Neurological Disorders	Monday 3:00 to 4:00		Chen
Fang Chen	Trans-ethnic Transcriptome-wide Association Study for Smoking Addiction in 1.3 Million Individuals Yields Insights into Tobacco Use Biology and Drug Repurposing	Monday 3:00 to 4:00		Chen-f
Li-Shiun Chen	Predicting smoking cessation treatment outcomes with genetic risk scores and biomarkers	Monday 3:00 to 4:00		Chen-LiShiun
Shuo Chen	Genetic Fine-mapping with Dense Linkage Disequilibrium Blocks: genetics of nicotine dependence	Monday 3:00 to 4:00		Chen-s
Apurva Chitre	Exponential increase in QTL detection with increased sample size in heterogeneous stock rats	Monday 3:00 to 4:00		Chitre
Olivia Corradin	Hypoacetylated neuronal enhancers in opioid overdoses converge on the regulatory circuit of specific genes	Monday 3:00 to 4:00		Corradin
Caitlin Crook	The interplay between cocaine and the feeding hormone leptin in genetically diverse rats	Monday 3:00 to 4:00		Crook
Renata Cupertino	Neural correlates of polygenic risk for cannabis use and cannabis use disorder	Monday 3:00 to 4:00		Cupertino
M. Imad Damaj	Genetic Variation in nicotine withdrawal in Mice	Monday 3:00 to 4:00		Damaj
Udita Datta	Naturally occurring variation in cocaine self-administration among high-diversity mouse populations	Monday 3:00 to 4:00		Datta
Jeremy J. Day	The extracellular matrix protein Reelin is enriched in cocaine-activated D1-MSNs and modulates transcriptional responses to dopamine	Monday 3:00 to 4:00		Day
Giordano de Guglielmo	Characterizaiton of individual differences in “addiction score” and choice between cocaine versus palatable food choice in Heterogeneous Stock (HS) male and female rats	Monday 3:00 to 4:00		de Guglielmo
Catherine DeMarino	Effects of Marijuana on Viral Transcription in HIV-1 Infected Cells and Resulting Extracellular Vesicle Release	Monday 3:00 to 4:00		DeMarino
Marissa Ehringer	Differential gene expression responses to oxycodone self-administration in the amygdala and prefrontal cortex of inbred rat strains	Monday 3:00 to 4:00		Ehringer
Kit K. Elam	Functional Polygenic Risk for Aggression Indirectly Predicts Adult Substance Use Disorder Diagnoses via Substance Use Offending in Emerging Adulthood	Monday 4:00 to 5:00		Elam
Luke Evans	Genetic architecture of four smoking behaviors using partitioned SNP heritability	Monday 4:00 to 5:00		Evans
Delaney Fischer	Novel Approach for Cell-Type Specific Profiling of Histone Post-Translational Modifications and Corresponding Gene Expression	Monday 4:00 to 5:00		Fischer
Megan Fox	Fentanyl abstinence causes neuron subtype specific structural and molecular changes in the nucleus accumbens	Monday 4:00 to 5:00		Fox
Hongyu Gao	Single cell analyses of putamen region from subjects with alcohol use disorders	Monday 4:00 to 5:00		Gao
Jonathan Gewirtz	Daily morphine exposure activates synaptogenesis and other neuroplasticity-related gene networks in the dorsomedial prefrontal cortex of male and female rats	Monday 4:00 to 5:00		Gewirtz
Michael Golding	Epigenetic Toxicity: Preconception Paternal Exposures and the Programming of Offspring Birth Defects	Monday 4:00 to 5:00		Golding
German Gornalusse	Chronic heroin use generates distinct cleavage patterns of tRNA-Gly-GCC in semen	Monday 4:00 to 5:00		Gornalusse
Rahul Guda	Integrated systems analysis of mixed neuroglial cultures proteome post oxycodone exposure: Implications for altered synaptogenesis	Monday 4:00 to 5:00		Guda
Mustafa Hakan Gunturkun	RatsPub: a webservice aided by deep learning to mine PubMed for addiction-related genes	Monday 4:00 to 5:00		Gunturkun
Megan Hastings Hagenauer	Genetic liability for internalizing versus externalizing behavior manifests in the adult hippocampus: A comparison of the results of transcriptional profiling studies performed in eight bred rat models	Monday 4:00 to 5:00		Hagenauer
Peter Hamilton	CREB-mediated activation of Zfp189 and re-engineering ZFP189 within mouse accumbens reveal transcriptional mechanisms governing cocaine-induced neuroadaptations	Monday 4:00 to 5:00		Hamilton
Alexander Hatoum	Genome-wide Association Study of multiple substance use disorders identifies novel loci related to mental and physical health	Monday 4:00 to 5:00		Hatoum
Jordan Hernandez	Double Trouble: Adolescent alcohol exposure in pre and postnatal oxycodone offspring	Monday 4:00 to 5:00		Hernandez
Alannah Hillmer	The genetic contribution of cannabis use in opioid addiction: An investigation into sex differences	Tuesday 2:00 to 3:00		Hillmer
Robert Hitzemann	Transcriptional Features Associated with Delay Discounting in HS Rats	Tuesday 2:00 to 3:00		Hitzemann
An Hoang	Epigenomic and machine learning strategies reveal key pathways that distinguish the opioid dependent brain	Tuesday 2:00 to 3:00		Hoang
Saeedeh Hosseinian	A forward genetic screen of ENU-mutagenised zebrafish identifies lines showing deficits in impulse control	Tuesday 2:00 to 3:00		Hosseinian
Spencer Huggett	Genes Identified in Rodent Studies of Alcohol and Nicotine Intake Are Enriched in GWASs of Human Substance Use	Tuesday 2:00 to 3:00		Huggett
Changhoon Jee	Cross-species functional validation of overlapping GWAS candidates between tobacco smoking in human and socially acquired nicotine IVSA in rats	Tuesday 2:00 to 3:00		Jee-1
Changhoon Jee	Neuropeptidergic regulation of Compulsive Seeking behavior in C. elegans	Tuesday 2:00 to 3:00		Jee-2
Cheng Ji	Identification of hepatic off-targets of anti-HIV protease inhibitors involved in organelle stress response and liver injury	Tuesday 2:00 to 3:00		Ji
Emma Johnson	The relationships between cannabis, tobacco, and schizophrenia: a genetically informed perspective	Tuesday 2:00 to 3:00		Johnson
Eric Otto Johnson	Genomic SEM GWAS of Opioid Addiction: Digging into OPRM1 and Beyond	Tuesday 2:00 to 3:00		Johnson
G Allan Johnson	Heritability of imaging phenotypes from combined magnetic resonance and light sheet microscopy	Tuesday 2:00 to 3:00		Johnson
Yan Jouroukhin	Role of astrocyte mitochondria in opioid withdrawal	Tuesday 2:00 to 3:00		Jouroukhin-1
Yan Jouroukhin	Role of astrocyte mu opioid receptors in morphine withdrawal	Tuesday 2:00 to 3:00		Jouroukhin-2
Marsida Kallupi	Characterization of addiction-like behaviors to oxycodone in Heterogenous Stock rats	Tuesday 2:00 to 3:00		Kallupi
Marcus Kaul	Chronic, low dose methamphetamine reveals sexual dimorphism in memory performance impaired by exposure to HIV-1 Tat protein	Tuesday 2:00 to 3:00		Kaul
Paul Kenny	Hedgehog-interacting protein in habenula regulates nicotine intake	Tuesday 2:00 to 3:00		Kenny
Alena Kozlova	Sex and brain region-specific gene expression and imprinting of nicotine sensitization and self-administration in rats inform GWAS findings of human smoking phenotypes	Tuesday 2:00 to 3:00		Kozlova
Brittany Kuhn	Sensation seaking behavior contributes to opioid dependence vulnerability in a sex-dependent manner	Tuesday 3:00 to 4:00		Kuhn
Donald Kuhn	Long access heroin self-administration significantly alters gut microbiome diversity, structure and composition	Tuesday 3:00 to 4:00		Kuhn-d
Adele Leggieri	Ankk1 regulates the dopaminergic response mediated by dopamine receptor D2 in zebrafish brain	Tuesday 3:00 to 4:00		Leggieri
Paige Lemen	Molecular and Phenotypic Causes and Networks Linked to Morphine and Naloxone Responses in the BXD Family: Time-Dependent Locomotor Effects	Tuesday 3:00 to 4:00		Lemen
Mark Anthony Leon-Duque	New chemical tools to elucidate the interactomics and the epigenetics of opioid drugs	Tuesday 3:00 to 4:00		Leon-Duque
Emily Levitt	Phenotypic structure of delay discounting in relation to diverse health behaviours in a general community sample of 10,701 adults	Tuesday 3:00 to 4:00		Levitt
Boyang Li	Incorporating local ancestry into methylation quantitative trait loci (meQTL) mapping for tobacco smoking in the African American population	Tuesday 3:00 to 4:00		Li-B
Michael Li	A social genomics perspective on methamphetamine use, HIV, and intimate partner violence	Tuesday 3:00 to 4:00		Li-m
Zhicheng Lin	Genetic basis for substance use exacerbation of COVID-19	Tuesday 3:00 to 4:00		Lin
Jyoti Lodha	Effects of Social Isolation and Ethanol Drinking on the PFC Transcriptome	Tuesday 3:00 to 4:00		Lodha
Ryan Logan	Transcriptional alterations in opioid use disorder reveal the interplay between neuroinflammation and synaptic remodeling across corticostriatal circuits	Tuesday 3:00 to 4:00		Logan
Falk Lohoff	Prescription opioid use and risk for major depressive disorder: a multivariable Mendelian randomization analysis	Tuesday 3:00 to 4:00		lohoff
Ryan Lusk	The alternative splicing and alternative polyadenylation transcriptional landscape of the HXB/BXH recombinant inbred rat panel and its role in predisposition to voluntary alcohol consumption	Tuesday 3:00 to 4:00		Lusk
Tianzhou Ma	White matter integrity and nicotine dependence in smokers: evaluating vertical and horizontal pleiotropy	Tuesday 3:00 to 4:00		Ma
Trudy Mackay	The Drosophila Brain on Cocaine at Single Cell Resolution	Tuesday 3:00 to 4:00		Mackay
Katarzyna Macur	Comprehensive response of HIV-infected human primary macrophages to methamphetamine exposure	Tuesday 3:00 to 4:00		Macur
Brion Maher	An Examination of Differential Methylation and Gene Expression in Dorsolateral Prefrontal Cortex Following Opioid Overdose	Tuesday 3:00 to 4:00		Maher
Maria Cecilia Garibaldi Marcondes	Detection of H3K4me3 identifies neuroHIV signatures and detects genomic effects of Methamphetamine in addiction pathways in post-mortem HIV+ brain specimens that are not eligible to transcriptome analysis	Tuesday 3:00 to 4:00		Marcondes
Lisa Maturin	The Cocaine and Oxycodone Biobanks: Two repositories of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of cocaine or oxycodone self-administration	Tuesday 3:00 to 4:00		Maturin
Stephen McGee	From the developers of Smokescreen: a booster panel for development of addiction polygenic risk scores	Tuesday 3:00 to 4:00		McGee
Skyler McShane	Positive Relationship between Set-Shifting, Learning Rate and Delay Discounting	Tuesday 4:00 to 5:00		McShane
Aleksandra Mech	Identification of lines showing altered sensitivity to rewarding effects of nicotine using a self-administration assay in zebrafish	Tuesday 4:00 to 5:00		Mech
Emily Mendez	Angiogenic Gene Networks are Dysregulated in Postmortem Brain of Opioid Use Disorder Subjects: Evidence from Multi-Omics and Imaging Approaches	Tuesday 4:00 to 5:00		Mendez
Munise Merteroglu	Gene regulatory responses to developmental drug exposures in zebrafish	Tuesday 4:00 to 5:00		Merteroglu
Philipp Mews	Epigenetic Priming Drives Aberrant Gene Expression Linked to Cocaine Relapse	Tuesday 4:00 to 5:00		Mews
Arojit Mitra	Discovery of novel, addiction-relevant genes through endophenotype modelling of Knockout Mouse Project (KOMP) data	Tuesday 4:00 to 5:00		Mitra
Swarup Mitra	Histone demethylase JMJD3 mediates opioid-induced cellular and behavioral plasticity	Tuesday 4:00 to 5:00		Mitra
Mahesh Mohan	Cannabinoid modulation of the microbiota-gut-brain axis in HIV/SIV infection	Tuesday 4:00 to 5:00		Mohan
Janitza L. Montalvo-Ortiz	Neuronal Methylome and Hydroxymethylome Profiling of Opioid Use Disorder	Tuesday 4:00 to 5:00		Montalvo-Ortiz
Alyssa Moore	Evaluating the stability of measures of motivation and preference in a behavioral economic drug self-administration procedure	Tuesday 4:00 to 5:00		Moore
Milad Mortazavi	Polymorphic SNPs, short tandem repeats and structural variants cause differential gene expression among inbred C57BL/6 and C57BL/10 substrains	Tuesday 4:00 to 5:00		Mortazavi
Anna Moszczynska	The Role of PARKIN in Methamphetamine Use Disorder	Tuesday 4:00 to 5:00		Moszczynska
Megan Mulligan	Rat reduced complexity model of oxycodone self-administration and stress responsiveness	Tuesday 4:00 to 5:00		Mulligan
Daniel Munro	Mapping genotype-expression associations in Heterogeneous Stock rat brains to advance behavioral genetics research	Tuesday 4:00 to 5:00		Munro
Elliot C. Nelson	Retrospective reports of itching with initial opioid misuse are strongly associated with risk of opioid use disorder (OUD), specific OUD symptoms, and more problematic course	Tuesday 4:00 to 5:00		Nelson
Jie Ni	PeerPub: a novel device for concurrent oral operant conditioning by two rats	Tuesday 4:00 to 5:00		Ni
Maria Niarchou	Identifying the medical phenome of patients with a prescription of buprenorphine in the Electronic Health Record (EHR) and the role of genetic risk	Tuesday 4:00 to 5:00		Niarchou
Steve Oghumu	X chromosome inactivation in sex disparities to substance use disorder	Tuesday 4:00 to 5:00		Oghumu
Angela Ozburn	Nicotine, midazolam, morphine, and methamphetamine intake in High Drinking in the Dark mice	Tuesday 4:00 to 5:00		Ozburn
Gita Pathak	Dissecting polysubstance use disorders via polygenic risk scoring	Wednesday 1:00 to 2:00		Pathak
Jack Pattee	Modeling recommendations and simulated power for the analysis of expression quantitative trait loci in the Hybrid Rat Diversity Panel	Wednesday 1:00 to 2:00		Pattee
McKenzie Pavlich	Characterization of addiction-like behaviors to alcohol in Heterogenous Stock rats	Wednesday 1:00 to 2:00		Pavlich
Robert Phillips	An atlas of transcriptionally distinct cell populations within the rat ventral tegmental area	Wednesday 1:00 to 2:00		Phillips
Tamara J. Phillips-Richards	Bidirectional Effects of a Taar1 SNP Conversion on Methamphetamine Traits	Wednesday 1:00 to 2:00		Phillips-Richards
Amara Plaza-Jennings	Cell-type specific genomics and transcriptomics of HIV in the brain	Wednesday 1:00 to 2:00		Plaza-Jennings
Oksana Polesskaya	High-throughput genotyping of HS rats using low-coverage sequencing	Wednesday 1:00 to 2:00		Polesskaya
Samuel Powell	Transcription Factor-Driven Production of Midbrain Dopaminergic Neurons from Human iPS Cells and Psychiatric Disease Risk Modeling	Wednesday 1:00 to 2:00		Powell
Alex Ramsey	Advancing the development of a genetically-informed behavioral intervention to promote tobacco treatment and cessation	Wednesday 1:00 to 2:00		Ramsey
Benjamin Reiner	Transcriptomic characterization of the nucleus accumbens in an animal model of opioid use disorder using single-nuclei RNA sequencing	Wednesday 1:00 to 2:00		Reiner
Jose Maria Restrepo	Expression-based polygenic score derived from corticolimbic DCC gene co-expression networks as a biomarker of SUD risk	Wednesday 1:00 to 2:00		Restrepo
Pamela Romero Villela	A gene-by-gene interaction analysis of rs16969968 and genome-wide loci on cigarettes per day in the UK Biobank	Wednesday 1:00 to 2:00		Romero Villela
Adrian Rothenfluh	Iterative ATAC-seq to home in on specific neuron subsets	Wednesday 1:00 to 2:00		Rothenfluh
Laura Saba	Webinar Series on Quantitative Genetics Tools for Mapping Trait Variation to Mechanisms, Therapeutics, and Interventions	Wednesday 1:00 to 2:00		Saba
Sandra Sanchez-Roige	Genome-wide association study of ‘not as prescribed’ prescription opioid use in 132,113 23andMe research participants	Wednesday 1:00 to 2:00		Sanchez-Roige
Michael Saul	The 5-HT1D receptor modulates volitional cocaine-related behaviors	Wednesday 1:00 to 2:00		Saul
Gretchen Saunders	Trans-ancestry GWAS meta-analysis of tobacco and alcohol use	Wednesday 1:00 to 2:00		Saunders
Lori Schirle	A Novel Data-Driven Approach to Evaluate the Spectrum of Opioid Use in Electronic Health Data	Wednesday 2:00 to 3:00		Schirle
Laurel Seemiller	Fear learning deficits after acute ethanol or MK-801 treatment in adolescent and adult C57BL/6J and DBA/2J inbred mice	Wednesday 2:00 to 3:00		Seemiller
Nancy Sey	Elucidating neurobiological processes underlying cigarette smoking and alcohol use traits	Wednesday 2:00 to 3:00		Sey
Alexander Smith	Dorsal Peduncular Prefrontal Cortex contains cells uniquely sensitive to opioids: Relevance to opioid reward and addiction	Wednesday 2:00 to 3:00		Smith
Jerry Stitzel	The Use of Chromosome Substitution Strains to Identify Genetic Modifiers that Alter the Impact of Chrna5 Deletion on Oral Nicotine Intake in Mice	Wednesday 2:00 to 3:00		Stitzel
Jing Sun	Epigenetic age acceleration among person who inject drugs with poorly controlled HIV	Wednesday 2:00 to 3:00		Sun
Boris Tabakoff	Are We Going in Circles: Circular RNA as Another Integral Member of the RNA World?	Wednesday 2:00 to 3:00		Tabakoff
Yalun Tan	Neuron Navigator 1 (Nav1) Regulates Learning, Memory and the Response to Multiple Drugs of Abuse (DOA)	Wednesday 2:00 to 3:00		Tan
Lisa Tarantino	Acute locomotor activation and behavioral sensitization to cocaine in the Collaborative Cross and Diversity Outbred mouse populations	Wednesday 2:00 to 3:00		Tarantino
Collin Teague	Phosphodiesterase 1b is an Upstream Regulator of a Key Gene Network in the Nucleus Accumbens Driving Addiction-Like Behaviors	Wednesday 2:00 to 3:00		Teague
Samikkannu Thangavel	HIV-1 Tat and Cocaine Impact Astrocyte Energy Metabolism: Roles of microRNA in Epigenetic Regulation	Wednesday 2:00 to 3:00		Thangavel
Lani Tieu	Identification of individual differences in response to methadone, buprenorphine, and naltrexone in animal models of opioid use disorder	Wednesday 2:00 to 3:00		Tieu
Dong-Binh Tran	Associations between microbiota and novelty behavior in mice with reference to cocaine addiction	Wednesday 2:00 to 3:00		Tran
Matthew Tran	Single-nucleus transcriptome analysis reveals cell type-specific molecular signatures across reward circuitry in the human brain	Wednesday 2:00 to 3:00		Tran-n
Mudit Tyagi	Cocaine-induced NFAT, NF-kB and AP-1 cooperate in facilitating HIV gene expression and replication	Wednesday 2:00 to 3:00		Tyagi
Mallory Udell	TailTimer: automating data collection for the rodent tail immersion assay	Wednesday 2:00 to 3:00		Udell
Hemayet Ullah	Host Targeted Antivirals Inhibit RACK1 mediated IRES Activities in HIV-1	Wednesday 2:00 to 3:00		Ullah
Denong Wang	Modulating ADAR-1 arm of innate immunity for HIV cure	Wednesday 2:00 to 3:00		Wang-d
Meiyue Wang	Does Population Structure Affect Murine Genome-Wide Association Study (GWAS) Results?	Wednesday 2:00 to 3:00		Wang-m
Qun Wang	Organoids as New Platform to Study Substance Use Disorders	Wednesday 3:00 to 4:00		Wang-q
Tengfei Wang	GWAS on socially acquired nicotine IVSA in heterogeneous stock rats highlights genes implicated in human smoking behavior	Wednesday 3:00 to 4:00		Wang-t
Xingyan Wang	Near Optimal Trans-ethnic Meta-Analysis of Smoking Phenotypes in 1.3 Million Individuals	Wednesday 3:00 to 4:00		Wang-x
Xusheng Wang	Genetic Architecture of Protein Expression in Rat Brain	Wednesday 3:00 to 4:00		Wang-xusheng
Brenna Williams	Genome-wide association study of psychostimulant-induced behavior in Drosophila melanogaster	Wednesday 3:00 to 4:00		Williams-b
Jin Xu	Characterization of an exon 7-associated seven transmembrane C-terminal variant, mMOR-1O, of the mu opioid receptor gene (Oprm1) in a conditional gene targeting mouse model	Wednesday 3:00 to 4:00		Xu-jin
An Ye	Lineage Tracing of Human Exosomal microRNAs to Brain Regions Impacted by Cocaine Use Disorder to Develop a Mechanistic Biosignature for Pharmacotherapy Response	Wednesday 3:00 to 4:00		Ye-an
Fengchun Ye	Regulation of HIV Silencing by Nuclear Receptors	Wednesday 3:00 to 4:00		ye-fengchun
Szu-Ying (Sam) Yeh	The Role of ∆FosB in the Development of Drug Addiction: Identifying ∆FosB Transcriptional Targets in Nucleus Accumbens	Wednesday 3:00 to 4:00		Yeh-Sam
Elizabeth Yen	The role of sex and inflammation on the developing brain in neonatal abstinence syndrome (NAS)	Wednesday 3:00 to 4:00		Yen-elizabeth
Dana Zeid	Behavioral and genetic characterization of contextual fear conditioning and related phenotypes using the BxD RI panel	Wednesday 3:00 to 4:00		Zeid
Jun-Jie Zhang	High-throughput identification of functional variants in gene enhancers associated with alcohol use disorder	Wednesday 3:00 to 4:00		Zhang-jun-jie
Xinyu Zhang	Deconvolution of bulk DNA methylome and a cell type specific epigenome-wide association study for HIV infection	Wednesday 3:00 to 4:00		Zhang-xinyu
Jessica Zhou	Cell type-specific multiomic analysis of substance use disorders in outbred rats	Wednesday 3:00 to 4:00		Zhou-jessica
Xiaoxi Zhuang	N6-methyladenosine and Epitranscriptomic Regulation of Learning and Responses to Cocaine	Wednesday 3:00 to 4:00		Zhuang-Xiaoxi
Katerina Zorina-Lichtenwalter	Shared genetic risk factors in pain conditions	Wednesday 3:00 to 4:00		Zorina-Lichtenwalter
Elizabeth Zuniga-Sanchez	Illuminating the molecular mechanisms of drug-induced neuroplasticity using the mouse retina	Wednesday 3:00 to 4:00		Zuniga-Sanchez

Abstracts and Agenda from January 2020 meeting

Meeting Agenda (PDF, 72KB)

Submitter	Title of Abstract	Session	#
Agrawal	Findings from the Substance Use Disorders Working Group of the Psychiatric Genetics Consortium	4	T11
Akbarian	A Chromosomal Connectome for Psychiatric and Metabolic Risk Variants in Adult Dopaminergic Neurons	C	1
Bacanu	Imputation of summary statistics using large reference panels increases the accuracy and resolution of genetic signals coming from metanalysis of substance use disorder	C	2
Bachtell	Phenotypic differences in oxycodone responses in the inbred rat strains	C	3
Bagley	Sex Chromosome Complement Influences Voluntary Ethanol Consumption in Adolescent Mice	C	4
Bailey	Heritable variation and genetic correlation of addiction-related phenotypes in the CC/DO recombinant inbred mouse panel	C	5
Baker	Dissecting the Genetic Basis of Variation in Cocaine and Methamphetamine Consumption in Drosophila melanogaster	C	6
Baker	Single-cell transcriptional responses to cocaine exposure in the Drosophila brain	C	7
Bandrowski	Addicted to FAIR data? The role of repositories and reproducibility in improving impact of data in addiction research.	6	T14
Bangasser	Sex differences in stress inoculation of addiction-like phenotypes	C	8
Barr	Prediction of alcohol and other substance use disorders using a polygenic score for broader externalizing risk.	C	9
Barry	Modeling nicotine and smoking exposures in the developing brain	C	10
Beierle	Nearly isogenic BALB/cJ and BALB/cByJ substrains differ in opioid state dependent learning, spontaneous withdrawal, and weight loss in response to oxycodone: Planning a reduced complexity cross.	C	11
Belancio	Custom RNA-Seq methods identify tissue- and age-specific patterns of retrotransposon expression in vivo	7	T18
Berrettini	Neonatal Opioid Withdrawal Syndrome: Observations in a Health System	C	12
Bidlack	Fibroblast Growth Factor 21 Attenuates Morphine-induced Preference, Tolerance, and Dependence Without Affecting Analgesia	C	13
Bogue	New tools to assess research replicability using the Mouse Phenome Database	C	14
Borrelli	Neonatal morphine administration (P1-14) in outbred CFW mice induces enhanced behavioral signs of withdrawal in females and a distinct brainstem transcriptomic profile compared to males	C	15
Branscome	Use of Stem Cell Extracellular Vesicles as a “Holistic” Approach to CNS Repair	C	16
Brieño-Enríquez	Reproductive decline and epigenetic effects of in utero opioid exposure	C	17
Browne	Transcriptional reprogramming of the brain reward system by heroin self-administration	C	18
Bubier	The Microbial community dynamics of cocaine sensitization in two behaviorally divergent Collaborative Cross strains.	C	19
Buck	Developmental nicotine exposure elicits multigenerational epigenetic anomalies in the frontal cortices, striata, and hippocampi of adolescent mice which co-occur with neurodevelopmental disorder-like phenotypes	C	20
Cadet	Mimicking methamphetamine use disorder with footshock punishment: epigenetic and transcriptional consequences in the rat brain.	9	T24
Calarco	The effect of developmental fentanyl exposure on mitochondrial gene expression in the brain and blood in C57Bl/6 mice	9	T27
Calipari	Divergent molecular adaptations in the nucleus accumbens control cocaine reinforcement in males and females	3	T7
Cates	Using published datasets to study the role of lncRNA in substance use disorders	C	21
Chakraborty	Genome to Phenome Implications of Social Stress-Induced Nicotine Preference: A Conspecific Aggressor-Induced Social Stress Model Integrated with a Nicotine Two-Bottle Choice Paradigm	C	22
Chandra	Egr3 regulates mitochondrial nuclear gene expression in nucleus accumbens neuron subtypes after cocaine exposure	C	23
Chen	Deep learning model using network topology of linkage disequilibrium patterns increases the accuracy of polygenic risk scores for smoking	C	24
Chesler	Interpreting human genetics of SUD using multi-species heterogeneous functional genomics data	6	T15
Chevalier	Characterizing the HIV-1 Proviral Reservoir in ART-treated Opioid Users	C	25
Choi	Optically Induced CRISPR Tool for Epigenome Editing in Cocaine Action	C	27
Choquet	Heritability Estimate of Postoperative Total Morphine Equivalents in New Persistent Opioid Users	C	28
Ciborowski	Investigation of Macrophage proteome exposed to methamphetamine: A Multiple Reaction Monitoring (MRM) approach	C	29
Cowen	Effects of Marijuana on Viral Transcription in HIV-1 Infected Cells and Resulting Extracellular Vesicle Release	C	30
Crist	Differential expression and transcription factor binding associated with genotype at a pharmacogenetic variant in OPRD1	D	1
Damaj	Genetic Variation in nicotine withdrawal in Mice	D	2
Datta	Cocaine self-administration profiles in the Founder Strains of the Collaborative Cross	D	3
Day	A dopamine-induced gene expression signature regulates neuronal function and cocaine response	3	T9
de Jong	Towards an infinite genetic map for the rat hybrid diversity panel	D	4
Demontis	The polygenic risk for cannabis initiation and cannabis use disorder in individuals with cannabis and multiple drug use disorders and comorbid psychiatric disorders	2	T3
Dick	Using the genetic architecture of substance use disorders to aid in gene identification: Findings from the Externalizing Consortium	8	T21
Donaldson	Predicting Risk of Opioid Addiction: Evaluation of Genetic Factors Using Machine Learning Algorithms	D	5
Dracheva	Extensive cell type-specific epigenetic reorganization of the OPRM1 locus in primate evolution	D	6
Edenberg	Updates from the Psychiatric Genetics Consortium on Alcohol Use Disorders	4	T10
Ehringer	The role of a priori-identified addiction and smoking gene sets in smoking behaviors	D	7
Elam	Genotype-Environment Correlation by Intervention Effects Underlying Middle Childhood Peer Rejection and Associations with Adolescent Marijuana Use	D	8
Engeln	Transcriptional adaptations in the ventral pallidum following cocaine self-administration	D	9
Evans	Investigating Genetic Susceptibility to Tobacco Smoking at rs16969968 based on Age at Onset of Regular Smoking	D	10
Feng	Neuron subtype specific role of DNA methylcytosine dioxygenase TET1 in cocaine addiction	D	11
Flores	The DCC gene network in the prefrontal cortex and striatum as a predictor of cognitive control and psychopathology	C	26
Fowler	Nicotine Mediates Extracellular Vesicle RNA Signaling in the Brain	3	T8
Fox	Neuron subtype specific structural and molecular changes following fentanyl abstinence	D	12
Gaines	Identification of a genetic locus and environmental factors influencing initial cocaine sensitivity in C3H substrains	D	13
Ganesh	Who dare-not smoke-pot – Can schizophrenia polygenic risk predict acute psychotic response to cannabis?	D	14
Goldberg	Systems Genetic Analysis of Nicotine Withdrawal Deficits in Learning Using the BxD Genetic Reference Panel	D	15
Haas	Genome-wide association studies of substance use in people living with HIV across the US	D	16
Hagenauer	A Meta-Analysis of Hippocampal Transcriptional Profiling Studies in a Selectively-Bred Rat Model Converges with Genetic Sequencing to Implicate Specific Candidate Genes and Pathways in the Liability for Internalizing	8	T22
Han	Unbiased genetic screen identifies the novel molecules critical for inhibitory control	D	17
Hatoum	Polygenic Risk Scores for Commonly Used Substances Predict Brain Structural differences in Drug Naïve Children	D	18
Hazel	Epigenetic variation in neurons from multiple brain regions	D	19
Jacobson	Digging Deeper: Tackling the Complexity of Genetics and Molecular Mechanisms for Addiction in Human and Model Organism Populations	6	T17
Jee	Genetic basis of Nicotine seeking behaviors in C. elegans	D	20
Johnson	Measures of consumption versus disordered substance use: evidence of different genetic architectures	2	T6
Johnson	NIDA Genetics Consortium Genome-wide Association Study of Opioid Addiction – The Endgame for Wave 1.	4	T12
Kallupi	Characterization of addiction-like behaviors to cocaine in Heterogenous Stock rats: Identification of two populations of resistant and vulnerable rats	D	21
Kapoor	Integrative analysis of omics summary statistics to identify genes associated with substance use disorders	D	22
Karam	The genetic basis of natural variation in amphetamine sensitivity in Drosophila	D	23
Kaul	Calbindin- and parvalbumin-positive neurons and microglia display sexual dimorphism in long-term responses to methamphetamine and HIV-associated brain injury	D	24
Kim	High-Throughput Screening of Circadian Rhythms and Strain-Dependent Relationships with Cocaine Addiction in Genetically Diverse Mouse Populations	D	25
Kozlova	Understanding the molecular basis of nicotine addiction by integrative functional genomic analyses in a rat model and hiPSC-derived DA neurons	D	26
Kuhn	Individual variation in addiction-related behaviors contributes to opioid dependence vulnerability	D	27
Kumar	Forward genetic ENU mutagenesis screen in mice identifies SrGAP3 as a regulator of cocaine responses	D	28
Kumar	Kockout Mouse Project (KOMP2) has a discovery engine for novel addiction genes	D	29
Liao	The International Complex Disease Alliance	5	T13
Lin	Dopaminergic Epistasis: Substance Use Disorders vs. Parkinson's Disease	D	30
Logan	Transcriptional signatures in the human postmortem brain reveal associations between molecular rhythm disruptions and opioid use disorder	A	1
Lu	Transferring the Knowledge between Different Populations and Species by Using a Functional Deep Neural Network	A	2
Mathis	Septal inputs to habenula regulate nicotine craving	9	T26
Maturin	The Cocaine and Oxycodone Biobanks: Two repositories of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of cocaine or oxycodone self-administration	A	3
Mews	Epigenetic priming underlies transcriptional disruption linked to cocaine relapse	A	4
Meyers	Association of Polygenic Liability for Cannabis Initiation and EEG Connectivity in Adolescence and Young Adulthood	A	5
Miao	Integrative analysis of epigenetic response to Methamphetamine overdose in rat brain	A	6
Mitchell	Lumping splitting and evolving: Strategies to characterize behavioral phenotypes associated with substance use	A	7
Mohan	Long term delta-9-tetrahydrocannabinol administration inhibits neuroinflammation in chronically SIV-infected rhesus macaques through regulating interferon responses and miRNA mediated pathways	A	8
Moszczynska	LINE-1 on the Move: A Report on Regional Differences in Brain LINE-1 Activity after Chronic Methamphetamine Administration	A	9
Mummidi	RNA binding protein HuR regulates CCL2 allelic expression imbalance	A	10
Nadeau	Phenotypic Noise, the missing dimension of phenotypic variation and disease risk	A	11
Neale	Multilevel Causal Genetic Modeling in the ABCD Dataset	A	12
Nelson	A GWAS of Opioid Withdrawal Symptom Clusters	A	13
Odegaard	Transgenerational epigenetic inheritance associated with prescription opioids abuse: Like mother, like child?	A	14
Palmer	Shared Sources of Genetic Variation Underlying the Transmissible Liability Index for Substance Use Disorders and Subsequent Cannabis Use	A	15
Palmer	Multi-trait Polygenic Prediction of Nicotine and Alcohol Dependence	A	16
Palmer	Comparative Neuro-Transcriptomics of Alcohol Use and Dependence	A	17
Palmer	All of us for rats: multiomic studies of addiction-related traits in outbred rats	A	18
Pan	Mu opioid-induced biased signaling through mu opioid receptor seven transmembrane full-length C-terminal splice variants	A	19
Parker	Measuring negative affective withdrawal in CFW mice: Implications for GWAS	A	20
Pathak	Genetic association of phenotypic typologies of polysubstance use disorders: A latent class approach	A	21
Payer	Alu retrotransposon: A common structural variant that can regulate transcript level and structure leading to disease risk	7	T19
Peltz	Computational Genetic Analysis of 8300 Biomedical Phenotypes and of Responses to Drugs of Abuse	A	22
Periyasamy	HIV Tat and morphine-mediated activation of astrocytes: Epigenetic involvement of NLRP6 inflammasome in HAND	A	23
Peterson	Representation of diverse populations in addiction genetics: a call to action.	A	24
Pfenning	Addiction-associated genetic variants implicate cell type- and region-specific cis-regulatory elements in addiction neurobiology	9	T25
Philip	Genetic correlations and quantitative trait locus mapping reveals shared and unique mechanisms underlying addiction predisposing novelty response traits	A	25
Polimanti	Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium	2	T5
Quach	Smoking-dependent expression QTL evidence in human nucleus accumbens among variants identified by the GSCAN consortium	A	26
Ramsey	Design and preliminary test of a personalized genetic risk tool to promote smoking cessation	A	27
Reiner	L1 Retrotransposons in Psychiatric and Substance Use Disorders	7	T20
Reynolds	Integrative cross-species analysis uncovers convergent genomic regulatory features associated with complex disease	A	28
Rice	SmokeScreen: A GWAS resource for Substance Abuse	A	29
Richards	Reduced Intake When Drugs Make You Cold	A	30
Rogers	Validation of a Large-Scale Dynamical Model of Macrophage/HIV Interaction for the Mathematical Analysis of Methamphetamine Emergent/Epigenetic Effects on HIV/AIDS Disease Progression Using Visual Statistical Inference	B	1
Rothenfluh	Mechanisms of cocaine aversion in Drosophila	B	2
Ruan	Striatal transcriptome-wide profiling of hnRNP H RNA-binding targets via CLIP-seq in response to methamphetamine identifies Oprk1 as a potential translational target underlying reduced behavior in Hnrnph1 mutant mice	B	3
Rutherford	Recovery Vital Signs	1	T1
Saba	Genetic differences in estrous cycle effects on the rat brain transcriptome	B	4
Salvatore	Social genetic effects for alcohol use disorder	B	5
Sanchez-Roige	Alcohol consumption and misuse have a distinct genetic basis	2	T2
Schoenrock	Genetic dissection of initial drug sensitivity and behavioral sensitization using the Collaborative Cross and Diversity Outbred mouse populations	B	6
Sedighim	HS rats with high addiction-like behaviors choose cocaine over palatable food in a discrete choice test	B	7
Seemiller	Nicotine Metabolism Genetics in C57BL/6J and NOD/ShiLtJ mouse strains	B	8
Shtutman	Drugs repurposing for the treatment of HIV-Associated Neurocognitive Disorder by AI-based literature mining	B	9
Sumner	The Internal Exposome, Opium Use, and Opioid Use Disorder	2	T4
Telese	Cell-type specific gene expression changes associated with adolescence exposure to THC in mice	B	10
Telese	Sequencing newly initiated transcripts to study transcriptional regulatory mechanisms in substance use disorders	B	11
Thangavel	Epigenetic Modification of Mitochondrial DNA in the Development of NeuroAIDS	B	12
Troiani	Validation of a DSM-5 OUD severity score derived from health record review	B	13
Troiani	Measuring Quantitative Traits of Alcohol Use Disorder in an Integrated Health System	B	14
Tyagi	Cocaine promotes HIV gene expression and replication by co-stimulating NFAT, NF-kB and AP-1, as major transcription factors.	B	15
Vassileva	Associations of polygenic risk scores with neurocognitive and psychiatric phenotypes in Bulgarian substance users	B	16
Verhulst	Analyzing latent propensities to addictive behaviors in a multivariate GWAS framework using GW-SEM.	8	T23
Walker	Adolescent Stress Results in Sex-Specific Reprogramming of the Reward Circuitry Transcriptome in Adulthood	B	17
Walss-Bass	Demyelination and Accelerated Aging as Mechanisms of Cocaine-induced Neurotoxicity	B	18
Weinstock	Influence of the microbiome on novelty behavior and cocaine addiction in mouse models.	B	19
Weiss	Successful Illumina Array Genotyping on Serum Stored For Three Decades	B	20
Williams	Genome-wide association study of psychostimulant-induced behavior in Drosophila melanogaster	B	21
Wimmer	Transcriptomics associated with opioid craving in the nucleus accumbens of male and females Long Evans rats	B	22
Wolstenholme	Adolescent binge ethanol slows oligodendrocyte maturation through regulation of histone methylation in the PFC	B	23
Won	Elucidating the neurobiological bases of cigarette smoking and nicotine dependence	6	T16
Yadid	PLX-PAD placental derived mesenchymal like adherent stromal cells as an effective cell therapy for cocaine addiction in a rat model	B	24
Zhang	In silico Epitope Mining and the Search for a Universal Carrier Protein	B	25
Zhang	An Efficient Method for Global Gene Regulatory Network Construction	B	26
Zhang	Epigenome-wide DNA Methylation Profiling: Methylation Capture Bisulfite Sequencing versus Infinium MethylationEPIC BeadChip	B	27
Zhang	MicroRNAs regulate the transgenerational impact of nicotine exposure and smoking	B	28
Zhong	Alcohol-induced histone H3 phosphorylation modulates deregulation of Brf1 and tRNA genes in hepatocellular carcinoma	B	29
Zlebnik	Cannabinoid exposure in adolescence dysregulates genes that orchestrate dopamine development and alters cocaine-motivated behavior	B	30

Abstracts and Agenda from January 2019 meeting

Agenda (PDF 415KB)

Abstracts

Submitter	Title of Abstract	Session	#
Arpana Agrawai	Updates from the Psychiatric Genomics Consortium's Substance Use Disorders Working Group	5	T11
Schahram Akbarian	Epigenome Profiling in Prefrontal Cortex Neurons Exposed to Opiates	4	T9
David Alvarez-Carbonell	Virus on the brain: Inflammation and cross-talk between microglia and neurons regulate HIV latency	D	40
Robert Anholt	Genetic Variation in Alcohol Induced Modulation of Drosophila snoRNAs	D	39
Venkata Atluri	Magneto electric nanoparticle based CRISPR-Cas9/gRNA delivery to eradicate latent HIV infection and neuropathology in the brain	D	38
Silviu-Alin Bacanu	Novel pathway transcriptomics method greatly increases detection of molecular pathways associated with substance use disorder	D	36
Silviu-Alin Bacanu	Direct imputation of summary statistics using large reference panels increases the resolution of genetic signals coming from metanalysis of substance use disorder	D	37
Jared Bagley	Heritable variation in voluntary alcohol drinking and blood ethanol concentrations in a genetically diverse inbred mouse panel	D	35
Brandon Baker	Dissecting the Genetic Basis of Variation in Cocaine and Methamphetamine Consumption in Drosophila melanogaster	D	34
James Baurley	Prediction of nicotine biomarkers from genotypes	D	33
Jacob Beierle	Mouse inbred strain survey of oxycodone addiction traits in an opioid multi-stage addiction assessment protocol	D	32
Chelsie Benca-Bachman	Cross-Species Prioritization of Genomic Loci for Nicotine Consumption	9	T15
Andrew Bergen	Biosignatures of Opioid Addiction Treatment Success (BOATS)	D	31
Wade Berrettini	Electronic Health Records in Evaluating the Potential for Opioid Use Disorder	2	T4
Jinbo Bi	Inferring Phenotypes from Substance Use via Collaborative Matrix Completion	D	30
Jean Bidlack	Fibroblast Growth Factor 21 Attenuates the Preference for Morphine in a Conditioned Place Preference Assay	D	29
Stephanie Bielas	Genetic regulation of personalized opioid response in cerebral organoids	D	28
Molly Bogue	Mouse Phenome Database 2.0: New tools and data resources for curated and integrated primary mouse phenotype data	D	27
Kristyn Borrelli	Reward sensitivity in Hnrnph1+/- mice following acute methamphetamine administration as measured via intracranial self-stimulation	D	26
Caroline Brennan	Population based forward genetic screen of mutagenized zebrafish identifies loci associated with nicotine preference and human smoking behavior	D	25
Camron Bryant	Gene mapping and editing of an intronic variant in Gabra2 in methamphetamine sensitivity and naloxone-induced aversion behaviors in a reduced complexity cross	D	24
Jason Bubeir	Genetic Variation in Opioid Induced Respiratory Depression in Mice	D	23
Matthew Buczynski	Enhanced nicotine reward in a mouse model of the P129T FAAH gene polymorphism	D	22
Hannah Cates	Revealing the chromatin-bound long noncoding RNA landscape of the brain	D	21
Marta Ceko	Predicting placebo analgesia - literature review and new perspectives	D	20
Ramesh Chandra	Cocaine-induced histone methylation on Egr3 and Nab2 promoters	D	19
Renchao Chen	Transcriptome and functional characterization of nucleus accumbens neurons reveal Tac2+ D1 neurons in regulating psychostimulant effect of cocaine	D	17
Hao Chen	Intermittent oral oxycodone self-administration in inbred strains of rats is heritable	D	18
Shuo Chen	Large-scale mediation analysis to identify gene-brain network-nicotine addiction pathways using imaging-genetics data	6	T16
Vidya Chidambaran	Biopsychosocial clusters based on genetic risk scores for chronic post-surgical pain in children undergoing spine fusion	A	42
Hélène Choquet	Genetic Ancestry and Tobacco Smoking Behavior	D	16
Pawel Ciborowski	Secreted metabolome of methamphetamine treated human primary macrophages	D	15
Olivia Corradin	Identifying pathogenic cell type of disease associated variants	B	39
M. Imad Damaj	A comparative phenotypic analysis of nicotine pharmacological effects and dependence behaviors in C57BL/6J and C57BL/6N mouse strains	D	13
M. Imad Damaj	Strain-Dependent Oral Nicotine Intake Using a Free-Choice Paradigm in Mice	D	14
Michael Dapp	Impact of HIV and Methamphetamine Use on the Nucleome in Individuals on Antiretroviral Therapy	D	12
Prasun Datta	Modulation of glutamate transporter, EAAT2 expression by epigenome editing.	D	11
Giordano de Guglielmo	Nociceptin/orphanin FQ reverses the escalation of oxycodone self-administration by normalizing GABA transmission in the amygdala in rats with high addiction-like behaviors	D	10
Catherine DeMarino	Effects of Marijuana on Viral Transcription in HIV-1 Infected Cells and Resulting Extracellular Vesicle Release	D	9
Price Dickson	Systems genetics discovery of genetic, genomic, and gene-by-environment mechanisms driving substance use and sensation seeking	D	8
Stella Dracheva	The role for DNA (hydroxy)methylation in epigenetic regulation of different brain cell types	4	T8
Jubao Duan	Understanding the molecular basis of nicotine addiction by integrative genomic analyses in a rat model and hiPSC-derived DA neurons	D	7
Howard Edenberg	Update from the Psychiatric Genomics Consortium: Alcohol	5	T12
Marissa Ehringer	Inbred Mouse Strains Selected for High and Low Open Field Activity Also Show Differences in Alcohol-Related Behaviors	D	6
Kit Elam	Using Gene Set Enrichment Analysis to Create Polygenic Risk Scores for Childhood Aggression: A Developmental Examination	D	5
Nazira El-Hage	Morphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone modifying enzymes in HIV-infected astrocytes	D	4
Michel Engeln	Transcriptional adaptations in the ventral pallidum following cocaine self-administration.	D	3
Dan Fabris	Exploring the CNS Epitranscriptome by MS-Based Approaches	D	2
Jian Feng	Neuron subtype-specific role of methylated DNA cytosine dioxygenase TET1 in cocaine addiction	D	1
Abdelali Filali-Mouhim	Non-coding RNAs drive increased fatty acid synthesis and reduce inflammation in cART treated HIV infected cocaine users	C	42
Hannah Frye	CNIH3 expression in female mice modulates hippocampal synapse stability and AMPAR-dependent memory and learning	C	41
Suhas Ganesh	Molecular intersections of cannabis exposure and psychosis expression using patient derived HiPSC neurons	C	40
Hugh Garavan	ENIGMA-Addiction: Gene-brain associations with SUD	C	39
Olivier George	The Oxycodone Biobank: A repository of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of oxycodone self-administration	C	38
Jonathan Gewirtz	Withdrawal-induced anhedonia as a protective factor in opioid addiction	C	37
Reza Ghanbari	An Untargeted NMR‐based Metabolomics Analysis to Investigate the Urinary Metabolites in Opium Users	C	36
Nathan Gillespie	GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia	C	35
Lisa Goldberg	Identification of a Locus on Chromosome Four Mediating Nicotine Withdrawal Deficits in Hippocampal Learning	C	34
Judy Grisel	Ex-Differences in Drug Sensitivity: Gonads or Non-coding RNAs?	C	33
Purnima Gupta	Magnetically guided non-invasive nanoformulations of Cas9/gRNA complemented with Opioid antagonist: A novel approach targeting HIV reservoirs in the brain	7	T17
F. Kent Hamra	Knockin Rat Model Production by Germline Gene Targeting in Sperm Stem Cells	C	32
Kyung-An Han	Impulsive flies shed light on new players for dysfunctional inhibitory control	C	31
Dana Hancock	Genome-wide DNA methylation differences in nucleus accumbens of smokers vs. nonsmokers	C	30
Elizabeth Heller	Chromatin-directed alternative splicing in brain reward regions	7	T19
Chad Highfill	Genetics of Cocaine and Methamphetamine Consumption and Preference in Drosophila melanogaster	C	29
Terry Hinds	E-cigarette nicotine exposure increases hepatic fat content reducing liver-derived fuel for the brain	C	28
William Hoffman	Trace Amine Associated Receptor 1 (TAAR1) SNP rs8192620 is associated with increased craving and altered striatal functional connectivity in methamphetamine use disorder (MUD)	C	27
Rebecca Hofford	The gut microbiome as a homeostatic regulator of striatal gene expression in response to opioids	C	26
Mingi Hong	Gene-environment interactions in holoprosencephaly	C	25
Goku Hu	Extracellular Vesicle-mediated small RNA delivery into the CNS	C	24
Jun Huang	The histone methyltransferase EZH2 primes the differentiation of follicular helper T cells during acute viral infection	C	23
Jordan Hughey	Fine Mapping Causal Variants of Smoking and Drinking Addiction Related Traits	C	22
Ovidiu Iancu	Network Approaches Identify Brain Regions and Gene Hubs Associated with Genetic Predisposition for Methamphetamine Intake	B	10
Hae Kyung Im	Exploring the mechanism behind drug addiction integrating predicted transcriptomic and radiomic data	C	20
Changhoon Jee	Compulsive behaviors in C. elegans as a model to study Substance Use Disorders	C	19
Emma Johnson	Large genome-wide association study of cannabis abuse and dependence: an update from the PGC Substance Use Disorders working group	C	18
Eric Johnson	NIDA Genetics Consortium Genome-wide Association Study of Opioid Addiction – An Update.	5	T13
Marsida Kallupi	Pharmacological treatments for opioid dependence in Heterogeneous Stock rats	C	17
Helen Kamens	Adolescent social stress influences later ethanol and nicotine behaviors and microRNA expression	C	16
Jaakko Kaprio	A Genome-wide association meta-analysis of the nicotine metabolite ratio and five other smoking related traits in smokers of European descent	C	15
Caline Karam	Flying high: Delineating the genetic basis of amphetamine sensitivity using a Drosophila behavioral model	C	14
Marcus Kaul	Neurotransmission-related gene expression reveals sexual dimorphism in long-term effects of methamphetamine and HIV-associated brain injury	C	13
Pamela Kennedy	Epigenetic mechanisms mediating cocaine-induced shifts from hippocampal to dorsolateral striatal behavioral learning and control	C	12
Paul Kenny	Habenular Tcf7l2 links nicotine addiction to diabetes	2	T13
Srivatsan Kidambi	METH elicits dose- and time-dependent autophagic cytotoxicity in primary astrocytes	C	11
Sam-Moon Kim	Strain Differences of Molecular Circadian Rhythms in Primary Fibroblasts Derived from Founders of Collaborative Cross and Diversity Outbred Mice	C	10
Zachary Klase	Drugs of abuse as drivers of epigenetic change in HIV-1 infection	C	9
Albert Ksinan	Externalizing and Internalizing Genetic Pathways to Alcohol Consumption and Alcohol Use Disorder Symptoms in College Students	C	8
Vivek Kumar	Integrated analysis of JAX-KOMP2 data reveals a cluster of genes predictive of addiction phenotypes.	C	7
Meena Kumari	Do exosomes hold the key to genetic and epigenetic modifications in drug addiction?	C	6
Tuuli Lappalainen	Functional variation in the human genome: lessons from the transcriptome	3	T5
Casey Lardner	Elucidating the cell type-specific transcriptional patterns differentiating stimulant versus opiate addiction	C	5
Kaycie Lawson	Methamphetamine alters innate immune signaling by inducing an IL-1β-miR-146a negative feedback loop and contributes to anti-retroviral drug resistance in CD4+ T-cells	C	4
Jun Li	Genetics of Novelty Seeking and Propensity for Drug Abuse in Outbred Rats	C	2
Yanchun Li	The histone demethylase KDM6B in the medial prefrontal cortex epigenetically regulates cocaine reward memory	C	3
Xiaoyu Liang	DNA methylation signature of Phosphatidylethanol Predicts Hazardous Alcohol Use	C	1
Yunlong Liu	Alcohol Abuse Associated Allele Specific Expression and Regulation in Human Brain Tissue	B	41
Dajiang Liu	Phenotype imputation integrating GWAS summary association statistics, deeply phenotyped cohorts and large biobanks Identifies novel loci for cotinine levels	B	42
Jingyu Liu	Opposite Epigenetic Modifications between Alcohol Use and Exercise Intervention	B	40
Qing Lu	A Kernel-Based Neural Network for High-dimensional Risk Prediction on Massive Genetic Data	B	38
Rui Luo	Transgenerational Effect of Smoking During Pregnancy on DNA Methylation of the Newborn	B	37
Morteza Mahmoudi	Development of Innovative Protein Corona Nanosystem Technology for Early Detection of Substance Abuse Disorders	B	36
Travis Mallard	Insights into the multivariate genetic architecture of externalizing spectrum behaviors and disorders: Preliminary results from the Externalizing Consortium	B	35
Aimee Manzoni-D'Arpino	A Parent’s Perspective: Personal Stories of Substance Use Disorder	1	T1
Maria Marcondes	Stable histone modifications in post-mortem brain tissue can help overcome quality issues to help identify neuroHIV signatures	B	34
Christina Markunas	Epigenome-wide analysis uncovers a blood-based DNA methylation biomarker of lifetime cannabis use.	B	33
Lisa Maturin	The Cocaine Biobank: A repository of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of cocaine self-administration	B	32
Paul McLaren	Polygenic analysis of genome-wide genotype data reveals genetic overlap between HIV acquisition and addiction traits	B	31
Raghu Metpally	Genomic analyses of prescription opioid dose in chronic opioid exposure	B	30
Philipp Mews	Epigenetic priming underlies transcriptional dysregulation in cocaine addiction	4	T10
Jacquelyn Meyers	Polygenic Influences on Alcohol Related Neurophysiological and Neurocognitive Processes across the Lifespan	B	29
Michael Miles	Genetic Analysis of Intermittent Access Ethanol Consumption in Diversity Outbred (DO) Mice	B	28
Mahesh Mohan	Long noncoding RNA landscape in the intestinal epithelium of delta-9-tetrahydrocannabinol treated chronically SIV-infected rhesus macaques	B	27
Kevin Morris	Recombinant protein guided activation of HIV; a means for target specific purging of proviral reservoirs in the brain	B	26
Megan Mulligan	Identification of Sex, Strain, and Entourage Effects in the Behavioral and Physiological Response to Cannabinoids	B	25
Joe Nadeau	The mean-ness of noisy biological systems	B	24
Michael Neale	Effects of Age, Sex and Race on Substance Abuse and Dependence Assessments	B	23
Elliot Nelson	A GWAS of Opioid Withdrawal Symptom Count	B	22
Katherine Odegaard	Transgenerational transcriptomic changes associated with prescription opioids abuse: How far has the apple fallen from the tree?	B	21
Abraham Palmer	Center for genetic studies of drug abuse in outbred rats	B	20
Rohan Palmer	Cross-Species Prioritization of Genomic Loci for Drug Addiction: An Example Using Alcohol Consumption	3	T6
Sarah Palumbo	Electronic Health Records in Evaluating the Potential for Opioid Use Disorder	B	19
Ying-Xian Pan	Pharmacological functions of alternatively spliced mu opioid receptor variants in conditional Oprm1 rat models generated by Easi-CRISPR	B	17
Ying-Xian Pan	Alternatively spliced mu opioid receptor intracellular C-termini encoded by exon 7 are important for fentanyl actions	B	18
Clarissa Parker	Measuring negative affective withdrawal in CFW mice: Implications for GWAS	B	16
Gary Peltz	Computational Genetic Discovery for SUD	2	T2
Palsamy Periyasamy	Cocaine-mediated microglial activation involves miR-148b-lncRNA XIST-DNMT1 axis-mediated epigenetic promoter DNA methylation of an anti-inflammatory gene, PPARG	B	15
Roseann Peterson	Cross-ancestry Genome-wide Analyses of Substance Use Behaviors in Schizophrenia: Findings from the Genomic Psychiatry Cohort.	B	14
Renato Polimanti	Genome-wide association study of opioid dependence from the Psychiatric Genomics Consortium	B	13
Dar’ya Pozhidayeva	Effects of Chronic Stimulation of Nucleus Accumbens on Binge Drinking and Transcriptome	B	12
Rebecca Prosser	Paternal cocaine consumption in mice sex-specifically alters F1 offspring cocaine preference, circadian rhythm responses, and striatal gene expression.	B	11
Benjamin Reiner	L1 retrotransposons in cocaine addiction	7	T18
Tamara Richards	A Single Nucleotide Replacement Restores Methamphetamine Traits to Low Addiction Risk Levels	C	21
Jim Rogers	Large Scale Dynamical Model of Macrophage/HIV Interaction for the Mathematical Analysis of Methamphetamine Emergent/Epigenetic Effects on HIV/AIDS Disease Progression	B	9
Qiu Ruan	CLIP-seq analysis of the RNA binding protein hnRNP H in striatum following methamphetamine administration in Hnrnph1+/- mice	B	8
Sarven Sabunciyan	Repetitive Element Expression is Altered in the Brain Following Glucocorticoid Exposure	B	7
Sandra Sanchez-Roige	Alcohol consumption vs. misuse: evidence for distinct genetic architecture	6	T14
Michael Saul	Genetics and sex govern the striatum transcriptional response to cocaine	B	6
Sarah Schoenrock	QTL mapping for initial sensitivity to cocaine using an F2 intercross of low and high responder inbred strains	B	5
Michael Shtutman	Inhibition of the DEAD Box RNA Helicase 3 prevents HIV-1 Tat- and cocaine-induced neurotoxicity by targeting microglai activation	B	4
Chang Shu	Peripheral blood DNA methylation markers are associated with HIV progression	B	2
Chang Shu	Epigenome-Wide Association Scan (EWAS) of opioid use among chronic injection drug users and in a post-mortem opioid overdose brain sample.	B	3
Susan Smith	Collaborative Cross RIS as a Mouse Model to Identify Genetic Polymorphisms that Modify Alcohol-Related Outcomes	A	41
Ryan Smith	Mapping Cell Types in the Human Putamen from Cocaine Abusers	B	1
Mallory Stephenson	Describing Polygenic Associations for Alcohol Use, ADHD Symptoms, Cigarette Use, and Educational Attainment: A Within-Family Comparisons Study.	A	40
Jinni Su	Interactive Effects Between Polygenic Risk and Social Support in Relation to Alcohol Dependence Symptoms Among European American and African American Adults	A	39
Bethany Sump	Molecular Mechanisms for Epigenetic Transcriptional Poised Memory State	A	38
Boris Tabakoff	Does the liver or the brain control voluntary alcohol consumption: using the HRDP	A	37
Andrew Talal	Understanding How HIV and Hepatitis C Virus (HCV) Infection Affects CYP2B6 Enzymatic Activity and Methadone Pharmacokinetics	A	36
Lisa Tarantino	Initial drug sensitivity and sensitization in the Collaborative Cross/Diversity Outbred founders	A	35
George Taylor	Selectively bred rats with low motivation to exercise may also be vulnerable to abuse drugs	A	34
Samikkannu Thangavel	Cocaine and HIV- Tat Impact Brain Energy Metabolism: Role in Mitochondrial Epigenetic Signature of DNA Methylation	A	33
Jay Tischfield	The NIDA Genomics Center Updated	A	32
Joey Trampush	GWAS of Cognitive Abilities and Risk for Substance Abuse	A	31
Vanessa Troiani	Quantitative Traits Associated with Opioid Use Disorder	A	30
Jill Turner	Altered Microglial Transcriptomic Changes and Signaling in the Nucleus Accumbens during Nicotine Withdrawal	A	29
Mudit Tyagi	Cocaine-stimulated signaling pathways enhance HIV gene expression by inducing the establishment of euchromatin structure via modulating the recruitment of different epigenetic enzymes at HIV LTR.	A	28
Kathryn Vaillancourt	Cocaine-related DNA methylation of IRX2 alters local 3D chromatin architecture in human brain cells.	A	27
Eric Vallender	Gene expression in the prefrontal cortex associated with impulsivity	A	26
Jasmin Vassileva	Machine learning reveals common and specific predictors of alcohol, cannabis, and nicotine dependence	A	25
Brad Verhulst	Developing Genome-Wide Structural Equation Modeling (GW-SEM) to analyze the genetic associations with substance use phenotypes	A	24
Consuelo Walss-Bass	Epigenetics of Cocaine Use Disorder: A Collaborative Case-Control Initiative in Blood and Brain	A	23
Qun Wang	Overdosed Vitamins Generated Epigenetic Changes to Intestinal Stem Cells	A	22
Nathaniel Weathington	Assessing the impact of opioid exposure on lung immune function and in acute ICU care after drug overdose	A	21
George Weinstock	Microbes, Novelty-Related Behavior, and Cocaine Addiction	A	20
Jenny Wilkerson	Non-coding RNAs as markers of opioid use and pathological pain	A	19
Jessica Williams-Nguyen	The importance of measuring substance use: A Mendelian randomization of chronic Hepatitis C and myocardial infarction	A	18
Katherine Wilson	Cocaine-induced remodeling of the nuclear lamina and 3D genome organization in neurons?	A	17
Mathieu Wimmer	The apple never falls far: paternal exposure to morphine has deleterious consequences on male progeny	A	16
Fred Wolf	A transcriptional control pathway for behavioral plasticity induced by ethanol	A	15
Jennifer Wolstenholme	Neighbor housing alleviates the behavioral and neurobiological consequences of social stress-induced drinking in a sex-dependent manner	A	14
Hyejung Won	Functional genomics resources for the human brain elucidates the neurobiological basis of schizophrenia.	A	13
Christina Woo	New chemical tools to elucidate the genetics and epigenetics of opioid addiction	A	12
Marcelo Wood	Epigenetic mechanisms in the medial habenula control reinstatement	A	11
Han Xie	Validated Antibody Database: a curated database of antibodies cited in formal publications	A	10
Gal Yadid	Dialogue between epigenetic mechanisms and microbiome in the progress of drug addicts' rehabilitation	A	9
Fengchun Ye	Modulation of HIV-1 replication in microglial cells by the competing orphan nuclear receptors Nurr1 and Nor1	A	8
Xinyu Zhang	Feature Selection of Smoking-Associated DNA methylation for Prediction on HIV Prognosis and Mortality	A	4
John Zhang	Extracellular Vesicle miRNA Screening On-Chip: Technology, Progress and Potential Application in Opioid Abuse Screening	A	5
Bo Zhang	Revealing the dynamic epigenetic changes of nucleus accumbens induced by methamphetamine overdose	A	6
Baohong Zhang	Nicotine exposure caused significant transgenerational impact on microRNA expression and related disorder in C. elegans	A	7
Mike Zhang	The influence of carrier proteins on the immunological efficacy of nanoparticle-based vaccines against nicotine addiction	A	3
Wei Zhang	A global transcriptional network connecting noncoding mutations to changes in tumor gene expression	3	T7
Shuping Zhong	Role of epigenetic regulation by histone H3 phosphorylation in non-coding RNA, tRNA transcription of breast cancer	A	2
Xiaoxi Zhuang	N6-methyladenosine and Epitranscriptomic Regulation of Learning and Responses to Cocaine	A	1

NIDA Genetics Consortium Meeting, June 16, 2018 - UCSD Campus

Agenda (PDF, 153KB)

Abstracts & Agenda from January 2018 meeting

View the Meeting agenda (PDF, 56KB)

Submitter	Title of Abstract	Session
Hiba Abloushi	Genome Wide Association Study of Substance Use Disorder in the United Arab Emirates population	A
Bianca Acevedo	Genetic markers underlying the natural addiction of love	C
Balasubrahmanyam Addepalli	Probing stress-induced effects on RNA and post-transcriptional modifications by LC-MS	B
Arpana Agrawal	Update from the Psychiatric Genetics Consortium	2
Marisela Agudelo	Single cell imaging flow cytometry as a novel epigenetic tool to detect post-translational modifications and extracellular histone release induced by substance abuse	B
Schahram Akbarian	Nuclear transcriptome and 3D genome mapping in dopaminergic neurons of adult human midbrain	4
Ethan Anderson	The histone methyltransferase G9a in the nucleus accumbens bidirectionally controls cocaine self-administration, stress-induced reinstatement, and anxiety-like behaviors	A
Silviu-Alin Bacanu	Novel pathway transcriptomics method greatly increases detection of molecular pathways associated with the drugs traits	B
Jared Bagley	Heritable variation in voluntary alcohol drinking in a genetically diverse inbred mouse panel	C
Lauren Bailey	Heritable variation in reward sensitivity and impulsive action and choice in a genetically diverse inbred mouse panel	5
Brandon Baker	Dissecting the genetic underpinnings of cocaine and methamphetamine consumption in Drosophila melanogaster	A
Sarah Barry	Histone deacetylase 5 nuclear localization mediates epigenetic changes that limit drug reward and suppress relapse to drug-seeking	A
James Baurley	Using artificial intelligence for learning substance use disorder biosignatures	C
Andrew Bergen	Tobacco use disorder treatment biomarkers	A
Jill Bettinger	SWI/SNF chromatin remodeling complexes are required for normal behavioral responses to acute ethanol exposure	D
Junaid Bhatti	Impact of Genetic Polymorphisms on Opioid Misuse: A Scoping Review	C
Jinbo Bi	A Genome-wide Association Analysis with Cocaine Use Disorder Accounting for both Phenotypic Heterogeneity and Gene-Environment Interplay	D
Jinbo Bi	Collaborative Phenotype Inference from Comorbid Substance Use Disorders and Genotypes	D
Kenneth Blum	Genetic Addiction Risk Score (GARS) Predicts Severity, Relapse & Personalized Medicine	B
Camron Bryant	Cyfip1 haploinsufficiency increases compulsive-like behavior and food consumption: Parent-of-origin effects and potential implications for Prader-Willi Syndrome	A
Camron Bryant	Fine mapping of a distal chromosome 1 region influencing opioid addiction traits in a reduced complexity cross	D
Jason Bubier	Detecting genetic variation in morphine LD50 in founder strains of the Collaborative Cross and Diversity Outbred mouse populations	7
Shilpa Buch	HIV-1 Tat-mediated upregulation of miR-34a activates NF-κB-mediated microglial inflammation via targeting the 3′-UTR of NLRC5	A
Nicole Cameron	Maternal and Paternal Lineage Contributions to Transgenerational Effects of Prenatal Alcohol Exposure	C
Dana Carroll	Nicotine Metabolite Ratio and Biomarkers of Exposure among American Indian Tobacco Users	A
Gregory Carter	Modeling Pleiotropy and Epistasis to Understand Genetic Complexity	1
Hannah Cates	Accumbal E2F3a mediates cocaine behaviors via transcriptome-wide regulation of gene expression and alternative splicing	7
Ramesh Chandra	Cocaine-induced histone methylation on Egr3 and Nab2 promoters	B
Sidi Chen	Developing direct in vivo genome editing and screening platforms in the mouse brain	5
Hao Chen	Social behavior and anxiety predicts nicotine self-administration in adolescent outbred rats	A
Li-Shiun Chen	Genetic risk, nicotine dependence, and the clinical benefit of cessation pharmacotherapy	D
Christine Cheng	Massively parallel single-nucleus transcriptomic profiling to identify dysregulated gene regulatory circuitry in opioid addicted human brain	8
Elissa Chesler	Heterogeneous functional genomics data integration for addiction biology	5
Doo-Sup Choi	Adolescence Chronic Caffeine Exposure Promotes Diurnal, Biphasic Mood Cycling and Reduces Dendritic Pruning Through DNA Epigenetics in Mice	A
Pawel Ciborowski	Systems Biology Approach to Investigate Epigenetic Regulation of Macrophages Exposed to HIV Infection and Methamphetamine	C
Shaunna Clark	Human alcohol brain methylation and biomarker discovery project	A
David Cordova	The Preliminary Efficacy of a Technology-Based HIV and Drug Abuse Preventive Intervention in a Youth-Centered Community Health Clinic: Opportunities for Incorporating Biomarkers of Exposure and Genetic Susceptibility	A
Olivia Corradin	Identifying pathogenic gene targets of noncoding GWAS risk loci using gene regulatory circuits	D
Richard Crist	Replication of the pharmacogenetic effect of rs678849 on buprenorphine efficacy in African-Americans with opioid use disorder	B
Matthew Dalva	Extracellular Phosphorylation of a Receptor Tyrosine Kinase Controls Synaptic Localization of NMDA Receptors and Regulates Pathological Pain	D
Imad Damaj	Cyfip2 plays an important role in nicotine reward in mice	A
Mariella De Biasi	The CHRNA5 variant rs16969968 alters how dopaminergic function changes during progression toward nicotine addiction and during nicotine withdrawa	A
Giordano de Guglielmo	Identification of genetic variants that contribute to compulsive cocaine and oxycodone intake in rats: Preliminary data and establishment of the cocaine/oxycodone biobanks	6
Rajeev Desai	Role of N-Methyl-D-Aspartate Receptor (NMDAR) in Co-Morbid Schizophrenia and Substance Abuse	D
Danielle Dick	The Spit for Science project: Characterizing Genetic and Environmental Influences on Patterns of Substance Use in College Students	D
Ditte Demontis	Genome-wide association study implicates CHRNA2 in cannabis use disorder	5
Elizabeth Do	Prenatal Smoke Exposure during Pregnancy and ADHD Symptoms within Offspring: An Examination of Sex Differences and Mediation by DNA Methylation Markers	A
Stella Dracheva	Regulatory signatures in primate neurons at cell type resolution	4
Aimee Dudley	High resolution genetic dissection of complex and quantitative traits in yeast	1
John Dziak	The Effect of Varenicline on Ethanol Consumption and Striatal Gene Expression Using Classical Analytical Tools and High-Dimensional Mediation Analysis	B
Howard Edenberg	Transancestral meta-analysis of alcohol dependence identifies novel genetic correlations	A
Marissa Ehringer	Profiling differential expression of miRNA in prefrontal cortices of tobacco smokers vs. non-smokers	A
Michael Engeln	Transcriptional adaptations in the ventral pallidum following cocaine self-administration	D
Prabagaran Esakky	Paternal exposure to cigarette smoke toxicants causes adverse developmental, neurological, and behavioral outcomes in the offspring	C
Babak Esmail-Azad	Opioid Addiction Susceptibility Testing Via Cytochrome P450 Pharmacogenetic And Personalized Brain Region Specific (VTA) Organoid Assays	B
Earl Ettienne	Pharmacogenetics and Opioid Use Disorder	C
Christie Fowler	Nicotine-Mediated Modulation of Choroid Plexus Function and Altered Circulating MicroRNA Expression	D
Reza Ghanbari	Metabolomics Investigation of Opiate Addiction: Golestan Cohort Study	C
Tom Gould	Effects of Nicotine Exposure During Adolescence on Adult Cognition, Dendritic Morphology, and Epigenome	C
Leonardo Guercio	The Blackfynn Platform for Rapid, Multi-Modal Data Integration, Analysis, and Collaboration to Enable New Approaches to Drug Addiction Research	C
Peter Hamilton	Engineering CRISPR constructs as tools for gene-targeted transcriptional reprogramming in mammalian brain to elucidate the causal pathogenic mechanisms of drug abuse	A
Joe Harford	A Nanocomplex Carrying siRNA Targeting TNFa with Potential to Blunt the Neuroinflammation that Underlies Opioid Tolerance	B
Elaine Hebda-Bauer	Genetics of Novelty Seeking and Propensity for Drug Abuse in Outbred Rats	6
Chad Highfill	Candidate Genes for Cocaine and Methamphetamine Preference in Drosophila melanogaster	A
Andrew Jaffe	Effects of smoking during pregnancy on the prenatal cortical transcriptome	B
Eric Johnson	NIDA Genetics Consortium Genome-wide Association Study of Opioid Addiction – Wave 1	2
Emma Johnson	Large genomewide association study of cannabis dependence: updates from the Substance Use Disorders working group of the Psychiatric Genomics Consortium	D
Angela Junglen	The role of CAMK2A in the comorbidity of PTSD/SUD in individuals seeking detoxification treatment	D
Caline Karam	Genome-wide association analysis of amphetamine sensitivity in Drosophila melanogaster	A
Marcus Kaul	Chronic, low dosage methamphetamine modifies memory performance compromised by exposure to HIV-1 Tat protein	A
Vivek Kumar	CYFIP2 mediated control of cocaine induced neuroadaptations in mice	A
Daniel Larach	Identifying genetic predictors of perioperative opioid use through a prospective cohort of genotyped and phenotyped surgical patients: The Michigan Genomics Initiative	B
Todd Lencz	Large-scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets	D
Dawei Li	Deletions in the SLC25A18 and ZNF490 Genes Associated with Alcohol Dependence–A Genome-wide Copy Number Variation Screen	8
Xuan Li	Role of dorsal striatal histone deacetylase 5 in incubation of methamphetamine craving	C
Yutao Liu	Serum Exosomes and miRNAs in Male and Female Current, Former and Non-Smokers	C
Ryan Logan	Circadian Rhythms and Opiates: Role of the Circadian Transcription Factor NPAS2 to Regulate Morphine Conditioned Reward	C
Elizabeth Long	The moderating roles of peer group deviance and parental monitoring on polygenic risk for alcohol use across adolescence	B
Qing Lu	A New Artificial Intelligence Tool for Substance Use and Dependence Research	5
Trudy MacKay	Where is the Missing Heritability Hiding? Lessons From Drosophila	1
Pamela Madden	Genetics and Epigenetics: the Addiction Phenotype, and the Adolescent Brain and Cognitive Development Study	B
Supriya Mahajan	Systems Biology Approach to Analysis of the Oral Microbiome in HIV-positive Opiate abusers	B
Cecilia Marcondes	Reactive Oxygen Species induced in innate immune cells by Methamphetamine impact RNA polymerase binding patterns and facilitate the AP-1-mediated transcription of IL1beta and TNFalpha	B
Christina Markunas	Genetically driven gene expression associated with nicotine dependence across ten brain regions reveals novel genes and brain regions	3
Luke Matthews	Correcting for Genetic and Cultural Nonindependence (Galton’s Problem) when Testing Genetic Associations with Substance Abuse	C
Ian Maze	Aberrant histone dopaminylation in the ventral tegmental area promotes relapse to cocaine	9
Jacquelyn Meyers	Early Trauma Exposure, Polygenic risk for AUD, and Neural Response Inhibition in Adolescence and Young Adults: Trajectories of Frontal Oscillations during a Go/NoGo Task	C
Jacquelyn Meyers	Interaction Between Polygenic Risk for Cannabis Use and Environmental Exposures In The Detroit Neighborhood Health Study	C
Michael Miles	Genetic Analysis of Intermittent Access Ethanol Consumption in Diversity Outbred (DO) and Progenitor Mouse Strains	C
Mahesh Mohan	Delta-9-Tetrahydrocannabinol mediated attenuation of gastrointestinal dysfunction in chronic SIV-infected rhesus macaques involves differential modulation of epithelial DNA methylation and T cell activation	D
Janitza Montalvo-Ortiz	Epigenome-wide association study of opioid dependence in European American women	C
Mike Neale	Measurement Non-invariance with Respect to Race and Gender in DSM Criteria for Substance Abuse and Dependence	D
Elliott Nelson	Retrospective accounts of subjective effects of initial opioid use differ between those with opioid use disorder (OUD) and opioid misusers who never progressed to OUD	C
Sean O'Sullivan	Opioid Withdrawal Shifts Amygdalar Transcriptome and is Correlated with Gut Dysbiosis	A
Chioma Okeoma	HIV and substance abuse may influence the evolution of exosomes (exosome speciation): Implication for biosignature	D
Abe Palmer	Genome wide association study of behavioral, physiological and gene expression traits in a multigenerational mouse intercross	B
Rohan Palmer	Multivariate Genetics Architecture of DSM-5 Alcohol Use Disorder	B
Ying-Xian Pan	Aberrant alternative pre-mRNA splicing of the mu opioid receptor gene, OPRM1, in the medial prefrontal cortex of human heroin abusers and heroin self-administering rats	D
Ying-Xian Pan	The role of alternatively spliced mu opioid receptor C-terminal tails in morphine tolerance, physical dependence and reward	D
Clarissa Parker	Measuring negative affective withdrawal in CFW mice: A pilot study	A
Qian Peng	Genome-wide studies uncover a potential burden of uncommon variants and polygenic basis of multiple-substance use disorders in an American Indian population	D
Francesca Peruzzi	A miRNA signature for cognitive deficits and alcohol use disorder in persons living with HIV/AIDS	D
Andreas Pfenning	Cell type and Brain Region-specific Impact of Nicotine Use-associated Genetic Variation	4
Robert Philibert	The Dose Response and Abstinence induced Reversion Curves for Cigarette and Alcohol Consumption using Clinically Implementable Droplet Digital PCR Assays	D
Tamara Phillips	MA intake and sensitization in mice with a non-functional trace amine-associated receptor 1	A
Renato Polimanti	Genome-wide association study of opioid dependence in 3,491 cases and 4,163 exposed-controls from the Psychiatric Genomics Consortium	A
Dina Popova	Impact of OPRM1 A118G on synaptic transmission in both human and mouse neurons	D
Elizabeth Prom-Wormley	Genetic and Environmental Contributions to Electronic and Conventional Cigarette Use in Young Adults: A Bivariate Analysis	C
Sathya Puthanveettil	A Long Noncoding RNA Critical for Synapse Function	B
Jill Rabinowitz	The Contributions of Genetic and Contextual Factors to Alcohol and Marijuana Use and Disorders in African-American Young Adults	C
Upal Roy	Role of DJ1 gene in cocaine addiction and HIV-associated cognitive impairment	D
Laura Saba	Introducing the NIDA Core Center of Excellence in Omics, Systems Genetics, and the Addictome	6
Sarven Sabunciyan	Transcriptome Differences In the Aging Schizophrenia Brain	B
Wolfgang Sadee	Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence	A
Yotam Sagi	Chromatin Remodeling Complex in Accumbal Neurons Regulates Reward and Pleasure	B
April Shu	DNA methylation markers associated with injection drug use status and HIV infection among chronic injection drug users in the ALIVE study	C
Dani Sisto	A Novel Approach to Accounting for Exposure in Genetic Association Studies of Drug Use Disorders – An Update	D
Christopher Skipwith	Building a Predictive Quantitative Genomics Framework for Identifying Endophenotypes in Opioid-Dependent Patients	C
Matthew Sloan	The OPRM1 A118G Polymorphism and Alcohol-Related Phenotypes: Converging Evidence Against Associations with Alcohol Sensitivity and Consumption	B
Lauren Slosky	Self-Administration in Genetically Modified Mice: A Streamlined Platform for the Identification of Addiction Biomarkers, Therapies and Disease Mechanisms	B
Kristy Soloski	Can family cohesion buffer genetic risk for alcohol use trajectories?	B
Bethany Stangl	Dopamine Transporter (Dat1) Gene Variation And Intravenous Alcohol Self-Administration In Non-Dependent Drinkers: Influence Of Sex Differences	B
Jerry Stitzel	Parental nicotine exposure elicits multigenerational nicotine preference and ADHD-like brain, behavioral, and epigenetic anomalies in adolescent mice	C
Laura Stroud	Epigenetic regulation of placenta NR3C1: Mechanism underlying the impact of prenatal marijuana on infant development?	D
Boris Tabakoff	The Construction of a Tool that Predicts the Pathways from the Genome to Phenotype	A
Yuan-XIing Tao	Contribution of DNMT3a to neuropathic pain genesis by downregulating Kcna2 in primary afferent neurons	D
Lisa Tarantino	The Collaborative Cross as a tool for studying the genetics of addiction-related phenotypes	B
Allison Tegge	DNA methylation levels as a biomarker for severity of opioid use	C
Samikkannu Thangavel	Cocaine and HIV- Neuropathogenes: Epigenetic signature of DNA Methylation Role in Brain Energy Metabolism	C
Thoprgeir Thorgeirsson	Results from the Decode GWAS study on addiction	2
Vanessa Troiani	Clinical and Genetic Risk Factors associated with Opioid Use Disorder in patients with Chronic Pain	B
Eric Turner	Chrna5-expressing neurons in the interpeduncular nucleus mediate aversion primed by prior stimulation or nicotine exposure	A
Jill Turner	Disruption of Hippocampal NRG3-ErbB4 Signaling Ablates Nicotine Withdrawal-Induced Anxiety-like Behaviors	A
Mudit Tyagi	Cocaine-stimulated MSK1 promotes HIV transcription/replication both by augmenting the activity/recruitment of transcription factors and inducing euchromatin structures at HIV LTR	B
John VanMeter	The Role of DRD2 in Adolescent Reward Processing	D
Jasmin Vassileva	Neurocognitive and personality dimensions of impulsivity as common and specific candidate endophenotypes for opiate and stimulant dependence	C
Norma Velazquez	A Drosophila model for developmental nicotine exposure	A
Scott Vrieze	Genetic associations with alcohol and nicotine use	3
Deena Walker	Adolescent Social Stress Results in Sex-Specific Transcriptional Reprogramming of The Medial Amygdala, A Critical Region for Sex Differences in Reward	B
Gemma Wallace	Applying advanced statistical modeling to genetic predictors of personality dimensions associated with addiction	D
Consuelo Walls-Bass	Gene Expression Profiling in the Dorsolateral Prefrontal Cortex of Subjects with Completed Suicide and Substance Abuse	B
Raymond Walters	Closing the gap on "missing" heritability	1
Frances Wang	Role of Genetically-Influenced 5-HT Functioning in a Bifactor Model of Psychopathology: Moderation by Fathers’ Substance Use Disorder	D
Craig Werner	Trim3 mediates cocaine craving via INO80-dependent transcriptional regulation	B
Jennifer Wolstenholme	Adolescent binge ethanol alters oligodendrocyte maturation and regulation of histone methylation in the PFC	C
Ke Xu	DNA methylation related to HIV-infected smoking associated with mortality in HIV-infected individuals	C

Abstracts from November 2016 meeting

Submitter	Title of Abstract	Session	Number
Abraham Palmer	Genome-wide association study of delay discounting identifies GPM6B and demonstrates co-heritability with smoking	Oral Presentation I	1
Arpana Agrawal	Psychiatric Genetics Consortium Update	Oral Presentation I	2
Thorgeir Thorgeirsson	Polygenic risk scores for schizophrenia and bipolar disorder associate with addiction	Oral Presentation I	3
Andrew Bergen	Smokescreen Translational Analysis Platform: Prediction of Nicotine Metabolism and Smoking Cessation	Oral Presentation I	4
Deborah Mash	Human Transcriptome Analysis of Cocaine Abuse Identifies Genes Associated with Adult Striatal Neurogenesis	Oral Presentation II	1
Amanda Mitchell	Longitudinal Assessment of Neuronal 3D Genomes in Mouse Prefrontal Cortex	Oral Presentation II	2
Changning Wang	EPIS - Epigenetic PET imaging in substance use disorder patients	Oral Presentation II	3
Heidi O'Neill	Modeling gene x environmental effects in the mouse: the multigenerational phenotypes of the interaction of the rs16969968 SNP with developmental nicotine exposure.	Oral Presentation II	4
Venetia Zachariou	A unique role of RGSz1 in behavioral responses to pain killers	Poster Session I	1
Yi Zhang	Neuron subtype-specific molecular profiling and gene editing in a mouse model of cocaine addiction	Poster Session I	2
John Rice	Targeted sequencing identifies genetic polymorphisms of flavin-containing monooxygenase genes that contribute to the risk of nicotine dependence in European and African Americans	Poster Session I	3
Alan R. Prossin	Genetic moderation of human sTNFR1 response to experimental pain: potential homeostatic mechanisms underlying endogenous analgesia.	Poster Session I	4
Makoto Taniguchi	HDAC5 and NPAS4 regulate cocaine reward-environment associations	Poster Session I	5
Patrick J. Muholland	Integrative synaptomics in heavy drinking macaques identifies cross-species proteogenetic targets for treating excessive drug-seeking	Poster Session I	6
Scott J. Moeller	Genetic Markers Associated with Brain Structural Abnormalities in Human Cocaine Addiction	Poster Session I	7
Caline Karam	Delineating the genetic basis of amphetamine sensitivity using a Drosophila behavioral model	Poster Session I	8
David Jentsch	Intravenous Cocaine Self-Administration in Inbred Mice: Genetic Correlation with Impulsivity and Genome-Wide Association Results	Poster Session I	9
Abraham Palmer	Genome-wide association study of behavioral, physiological and gene expression traits in outbred CFW mice.	Poster Session I	10
Kirk Wilhelmsen	Genome-wide meta-analysis identifies seven novel susceptibility signals for nicotine dependence	Poster Session I	11
Laura Saba	An Influential Novel Transcript in a Systems Genetic Model of Alcohol Consumption	Poster Session I	12
Betsy Ferguson	A Genome-Wide Approach to Efficiently Identify Replicable DNA Methylation Regions Associated with Alcohol Use	Poster Session I	13
Miri Gitik	Choline supplementation in an adolescent nicotine exposure model- a whole genome epigenetic perspective.	Poster Session I	14
Arpana Agrawal	Genomewide association study identifies a novel locus for cannabis dependence	Poster Session I	15
S. ZHONG	Alcohol-induced histone H3 phosphorylation mediats RNA Pol III gene transcription	Poster Session I	16
Alfredo Ghezzi	CBP mediated control of long-term drug neuroadaptation in Drosophila	Poster Session I	17
Mahesh Mohan	Delta-9-Tetrahydrocannabinol mediated attenuation of intestinal inflammation in chronic SIV-infected rhesus macaques involves differential modulation of anti-microbial defensins, pro-inflammatory gene and microRNA expression amidst high viral loads	Poster Session I	18
Danielle Dick	The Spit for Science project: Characterizing Genetic and Environmental Influences on Patterns of Substance Use in College Students	Poster Session I	19
Diana Fishbein	Interactions between DAT1 and OPRM1, subcortical volume and later alcohol use in alcohol naïve youth.	Poster Session I	20
Kristine Marceau	Cortisol-related Genes and Substance Use Severity at age 16 years	Poster Session I	21
Mary Kay Lobo	Cell subtype transcriptional regulation of mitochondrial dynamics in cocaine action	Poster Session I	22
Yuva Kondaveeti	Cocaine Induces changes in the expression of lncRNAs in T cells	Poster Session I	23
Marcus Kaul	HIV-1/gp120 protein and methamphetamine induce lasting alterations in four major neurotransmission systems of the central nervous system	Poster Session I	24
Chioma M. Okeoma	Cocaine alters semen exosome cargo composition and anti-HIV activity	Poster Session I	25
Andew J. Rennekamp	Target-agnostic CNS drug discovery using high-throughput behavioral chemical screening in zebrafish larvae identifies a new role for sigma-1 receptors in the vertebrate brain.	Poster Session I	26
Qing Lu	A New Method Founds Evidence of Genetic Heterogeneity in Nicotine Dependence	Poster Session I	27
Jennifer T. Wolstenholme	Adolescent binge ethanol alters histone methylation in the PFC leading to lasting memory deficits and increased ethanol sensitivity	Poster Session I	28
Chris Bizon	Association and Linkage Analysis of Nicotine Dependence from Whole Genome Sequencing of Family Data Suggest a Novel Role for BBS5	Poster Session I	29
Darius Bost	Association of addiction phenotypes to predicted transcript levels	Poster Session I	30
Gustavo Turecki	Impact of chronic cocaine use on the human striatum methylome	Poster Session I	31
Elisa M. Trucco	A Developmental Perspective on the Role of Genes on Substance Use Disorder	Poster Session II	1
Frederick Wolf	SIR2/SIRT1 Disinhibition of Gene Expression by Acute Alcohol Leads to Presynaptic Changes and Behavioral Plasticity	Poster Session II	2
Joseph Bloom	Nicotine Dependence Associated with Functional Variation in FMO3	Poster Session II	3
Peter Hamilton	Engineering zinc-finger protein and CRISPR/Cas9 constructs to model the epigenetic and transcriptional phenomena that underlie cocaine-related behaviors	Poster Session II	4
Clarissa Parker	Genome-wide mapping of ethanol sensitivity in the Diversity Outbred mouse population	Poster Session II	5
Boris Tabakoff	The Hybird Rat Diversity Rat Panel for Addiction Research	Poster Session II	6
Lindsay Farrer	Genome-wide Association Study of Amphetamine Related Stimulant Dependence	Poster Session II	7
Brian Smith	The genetic and epigenetic architecture of behaviors related to drug seeking and abuse: The honey bee as a new animal model	Poster Session II	8
Scott Mackey	Genetic risk and nicotine exposure interact on the structure and function of the ventromedial prefrontal cortex in adolescents	Poster Session II	9
Travis T. Mallard	Genome-wide polygenic scores for schizophrenia are associated with substance use during emerging adulthood	Poster Session II	10
Lisa Goldberg	Identification of a major QTL influencing oxycodone behavioral sensitivity and dependence in C57BL/6 substrains	Poster Session II	11
David Brazel	Interim results from the GSCAN exome chip project	Poster Session II	12
Robert Philibert	Quantitative DNA Methylation Analyses Using Digital Droplet PCR Sensitively Detects Surreptitious Smoking in Adolescents.	Poster Session II	13
Phillip K. Liu	Epigenetics of Drug Sensitization: MicroRNA and HDAC5 expression in Amphetamine-induced Neural Remodeling	Poster Session II	14
Gal Yadid	Time Window for DNA methylation in Incubation of Cocaine Craving	Poster Session II	15
Fereshteh S. Nugent	Epigenetic reversal of maternal deprivation-induced dopamine cell hyperexcitability and synaptic mislocalization of AKAP150 within the VTA	Poster Session II	16
Pam Madden	Genetics, the Addiction Phenotype, and the Adolescent Brain and Cognitive Development Study	Poster Session II	17
Ana Ventuneac	Integrated (iCare) at Mt. Sinai	Poster Session II	18
Michael Stallings	Etiological Overlap Between Impaired Sex and Risky Sexual Behavior	Poster Session II	19
Kyung-An Han	Genetic and social factors critical for inhibitory control	Poster Session II	20
Rudra Pratyaydipta	Effect of microRNA expression on alcoholism: A study in a panel of recombinant inbred mouse strains	Poster Session II	21
Erin Calipari	Withdrawal from cocaine self-administration alters the transcriptional profile of cocaine across six brain regions	Poster Session II	22
Bradley E. Aouizerat	The Women’s Interagency HIV Study (WIHS): A Diverse Cohort Well Suited to Molecular Epidemiology Studies of Substance Abuse	Poster Session II	23
Ron Hart	Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele	Poster Session II	24
Jiang Gui	Efficient Survival Multifactor Dimensionality Reduction Method for Detecting Gene-Gene Interaction	Poster Session II	25
Anna Dorothy Asimes	Pre-conception Maternal and Paternal Binge Alcohol Exposure Lead to Distinct DNA Methylation Patterns in Alcohol-Naive Male Offspring	Poster Session II	26
Jinbo Bi	Multi-view Singular Value Decomposition for Disease Subtyping and Genetic Associations	Poster Session II	27
Ming D. Li	A second update on susceptibility genes for nicotine dependence identified by genome-wide linkage, candidate gene association, genome-wide association, and targeted sequencing approaches	Poster Session II	28
Nora Bizzozero	Neuronal enriched RNA-Binding Protein HuD and microRNA miR-495 oppositely regulate cocaine induced addiction-related gene expression and place preference behavior	Poster Session II	29
Ke Xu	Identifying the gene co-expression module for tobacco smoking that is regulated by DNA methylation	Poster Session II	30
Todd Hulgan	Meth and Genetically-Predicted Expression of the Cytoskeletal Protein Spectrin Gene Neurocognitive Function in HIV	Poster Session II	31
Caroline Brown	Pharmacogenetic Modulation of the Behavioral Effects of Buprenorphine in a Mouse Model of the OPRM1 (A118G) Polymorphism	Poster Session III	1
Zhiping Pang	Synaptic mechanisms of OPRM1 A118G (MOR N40D) gene variants in human neurons	Poster Session III	2
Ethan Carver	Gene Regulation and Viability of Cell Cultures Exposed to E-Cigarette Refill Solutions	Poster Session III	3
Z Carl Lin	EIF3F Genetics of Substance Abuse	Poster Session III	4
Dana Hancock	Genome-wide Interaction Analysis with Sex Reveals PEX11G as a Novel Gene for Nicotine Dependence	Poster Session III	5
Paulo A. Ferreira	Control of gene-environment interactions by the Ran-binding protein 2 (Ranbp2) and its stresssensing partners as venues to dissect the genetic basis of addiction behaviors engendered by drug abuse	Poster Session III	6
Andon N. Placzek	eIF2α-mediated translational control regulates cocaine-and nicotine-induced synaptic potentiation in mouse midbrain dopamine neurons and neuronal responses in human smokers	Poster Session III	7
Tamara Phillips	Evidence for an epistatic effect of Oprm1 and Taar1 in risk for methamphetamine consumption	Poster Session III	8
Roseann Peterson	Evidence for shared genetic risk between schizophrenia and smoking behaviors: Findings from the Psychiatric Genomics Consortium.	Poster Session III	9
Renato Polimanti	Risk alleles identified in a genome-wide gene-by-cannabis dependence interaction analysis of risky sexual behaviors	Poster Session III	10
Camron Bryant	Cytoplasmic FMR1-interacting protein 2 is a major genetic factor underlying binge eating	Poster Session III	11
Shauna Clark	Discovering methylation biomarkers of smoking and associated health risks	Poster Session III	12
Ashiwel Undieh	Psychostimulant-induced Alterations in Epigenetic DNA Methylation of Neural Genes: Toward a Pharmacological Separation of Euphoric and Neuroadaptive Mechanisms?	Poster Session III	13
Pradeep Bhide	Nicotine-induced DNA methylation in spermatozoa: Consequences for offspring’s behavior and gene expression in the brain	Poster Session III	14
Jinying Zhao	An Epigenome Wide Association Study on Alcohol Consumption: A Monozygotic Twin Study	Poster Session III	15
S.A. Eisenstein	Dopamine-related Genetic Profile is Associated with Negative Symptom Severity, Reward Expectancy, and Behavioral Inhibition	Poster Session III	16
Su Guo	Explore a natural variation of light/dark preference behavior in zebrafish: Genetic or epigenetic?	Poster Session III	17
Michael Miles	Behavioral genomic and genetic analysis of chronic nicotine and withdrawal in mouse BXD strains.	Poster Session III	18
Johana Alvarez	Heightened Baseline Anxiety-Like Behavior in Mice with Escalating Cocaine Consumption During Extended Access Cocaine Self-Administration	Poster Session III	19
Stephen L. Boehm	Short-term selective breeding for adolescent sensitivity to tetrahydrocannabinol- (THC-) induced locomotor sedation in mice.	Poster Session III	20
Susan Smith	High-Throughput Transcriptome Sequencing to Identify Genetic Modifiers of Sensitivity to Alcohol	Poster Session III	21
Christie Fowler	Nicotinic Modulation of the Choroid Plexus and Altered Circulating MicroRNA Expression During Chronic Nicotine Self-Administration	Poster Session III	22
Shilpa Buch	Cocaine-mediated promoter DNA methylation of microRNA-124 promotes microglial activation through TLR4 signaling	Poster Session III	23
Gary Siuzdak	Cloud-Based Systems Biology Analyses Guided by Metabolomics	Poster Session III	24
Jinbo Bi	Machine learning to identify highly heritable components of substance use disorders	Poster Session III	25
Erika Andrade	Neuronal Subtype-Specific Translational Changes Following Extended-Access Cocaine Self-Administration in Mice	Poster Session III	26
Sudheesh Pilakka-Kanthikeel	Cocaine reactivates latent HIV-1 by down regulating anti-HIV long-non coding RNAs	Poster Session III	27
Ming D. Li	Characterization of regulatory mechanisms at DNA variant, methylation and RNA levels for 57 tobacco smoking susceptibility genes in human brain	Poster Session III	28
Brion Maher	Circulating DNA methylation markers associated with injection status and HIV infection among chronic injection drug users in the ALIVE study.	Poster Session III	29
Michele T. Juarez	Acute exposure of Nicotine during Drosophila puncture injury activates an epidermal wound response	Poster Session III	30
Richard C. Crist	A polymorphism in the OPRM1 3’ untranslated region is associated with methadone efficacy in treating opioid dependence	Poster Session IV	1
Imad Damaj	The b3 subunit of the nicotinic acetylcholine receptor (nAChR) is required for nicotine withdrawal but not nicotine reward	Poster Session IV	2
Igor Zhulin	Establishing the Precise Evolutionary History of a Gene Improves Prediction of Disease-causing Missense Mutations	Poster Session IV	3
Li-Shiun Chen	Genetic risk can be decreased: Quitting smoking decreases and delays lung cancer for smokers with high and low CHRNA5 risk genotypes - A Meta-analysis	Poster Session IV	4
Xiangning Chen	Integration of Gene Expression in animal studies with GWAS in human datasets to Identify Risk Genes for Nicotine Dependence	Poster Session IV	5
Jared Bagley	The effects of prenatal stress on cocaine reward, cocaine locomotion and sensorimotor processing are heritable in the BXD recombinant inbred strain panel	Poster Session IV	6
Rohan Palmer	Estimation of the Genome-wide Additive Genetic Covariance Across Subjects of European and African Ancestry: An Example Using Alcohol Dependence	Poster Session IV	7
Elliot Nelson	Meta-analysis of comparisons to non-dependent misusers implicates CD244 involvement in opioid dependence	Poster Session IV	8
Kirk Wilhelmsen	Whole Genome Sequence Study of Cannabis Dependence: Associations with Regulatory Elements Identified by the Roadmap Epigenomics Project	Poster Session IV	9
Eric O. Johnson	Multi-ancestry GWAS Identifies Novel Variants Associated with HIV-1 Viral Load Set-point	Poster Session IV	10
Laura Stround	Epigenetic Regulation of Placental NR3C1: Mechanism Underlying Prenatal Programming of Infant Stress Response by Maternal Smoking During Pregnancy?	Poster Session IV	11
Shilpa Buch	HIV-1 TAT-mediated epigenetic downregulation of miR-124 targets MECP2 and promotes microglial activation	Poster Session IV	12
Michelle M. Jacobs	HIV-related neurocognitive impairment is related to polymorphisms in CCR2 and CD163 in the absence of cocaine and opiate dependency	Poster Session IV	13
Gregory Sartor	BET bromodomains regulate neurobehavioral responses to psychostimulants	Poster Session IV	14
Viranu Sueblingvong	Alcohol induces profibrotic fibroblast phenotype via induction of DNA methyl transferase.	Poster Session IV	15
Jasmin Vassileva	Behavioral Phenotypes of Impulsivity in Substance Dependent Individuals in Protracted Abstinence: Insights from ‘Pure’ Heroin and Amphetamine Users	Poster Session IV	16
Andrew Talal	Telemedicine-based Management of Hepatitis C Virus (HCV) Infection for Individuals on Opiate Agonist Treatment	Poster Session IV	17
Brion Maher	A Novel Approach to Accounting for Exposure in Association Studies of Drug Use Disorders	Poster Session IV	18
Rae Silver	Novel noninvasive voluntary methamphetamine inhalation paradigm for long-term studies of neuroinflammation and drug-seeking behavior	Poster Session IV	19
Kristin G. Ardlie	Specificity of alternative splicing in brain tissues from the GTEx project	Poster Session IV	20
Narasimhan J. Venkatachari	Transcriptome analysis of Peripheral Blood Mononuclear Cells from individuals with HIV-1 associated neurocognitive disorder identifies key players associated with neuropathogenesis and Marijuana use.	Poster Session IV	21
Pawel Cirborowski	Systems biology approach reveals novel insights into altered functions of HIV-1-infected or methamphetamine exposed macrophages.	Poster Session IV	22
Lee Campbell	Creation and characterization of the HIV-nanoLuc CHME-5 cell line	Poster Session IV	23
Bi Xuan	A Statistical Method for Advancing Neuroimaging Genetics	Poster Session IV	24
Tom Gould	Paternal nicotine exposure trans-generationally alters fear response and cholinergic function: potential epigenetic mechanisms	Poster Session IV	25
Dan Iancu	Genetic Selection for Methamphetamine Intake Rewires Brain Transcriptional Networks	Poster Session IV	26
Fereshteh S. Nugent	Changes in neuronal excitability and histone modifications within the LHb may underlie anxiety and depression following early life stresses	Poster Session IV	27
Shuanglin Hao	Epigenetic modification of MCU in the spinal cord dorsal horn in chronic morphine tolerance and HIV-related neuropathic pain state	Poster Session IV	28
Lucia Carvelli	Embryonic exposure to amphetamine alters the activity of the dopamine transporter in adult animals and progeny	Poster Session IV	29