NIDA Genetic Consortium Meetings & Abstracts Archives

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Abstracts and Agenda from May 2023 meeting

Welcome

The Genetics and Epigenetics Cross-Cutting Research Team of the National Institute on Drug Abuse invites you to attend the May 16-17, 2023 NIDA Genetics and Epigenetics Cross-Cutting Research Team Meeting at Natcher Auditorium on the NIH Campus in Bethesda, MD. This is an in-person meeting. We expect to have more than 215 scientific presentations.

Meeting Dates and Times

  • Tuesday, May 16th: - 9:00 a.m. to 5:30 p.m.
  • Wednesday, May 17th  - 9:00 a.m. to 5:00 p.m.

Agenda and Meeting Abstracts

May 16 – Keynote (9:15 am – 9:45 am)
TimeFirst NameLast NameEmailAbstract Title
9:15AndreToussaintat3658@columbia.eduUnderstanding Substance Abuse from Scientific and Human Perspectives
May 16 – Session 1 (9:45 am – 11:00 am) - Single cell transcriptional and chromatin profiling of brain reward structures identifies new candidate targets in substance use disorders Eric Nestler and Jeremy Day, Chairs
TimeFirst NameLast NameEmailAbstract Title
9:45KristenMaynardkristen.maynard@libd.orgIntegrated single cell and spatial transcriptomic approaches for defining the molecular anatomy of reward circuitry in the human brain
10:00MarineSalerymarine.salery@mssm.eduCapturing and profiling cocaine-recruited Arc neuronal ensembles encoding drug-context associations in the Nucleus Accumbens.
10:15JenniferTuscherjtuscher@uab.eduMultiomic profiling of the rat nucleus accumbens reveals cell-type specific chromatin remodeling and transcriptional alterations after cocaine experience
10:30BenjaminReinerbcreiner@pennmedicine.upenn.eduSingle nuclei transcriptomic analysis of rat nucleus accumbens reveals cell type-specific patterns of gene expression associated with volitional morphine
May 16 – Special Presentation (11:00 am – 11:10 am)
TimeFirst NameLast NameEmailAbstract Title
11:00AnitaBandrowskibandrow@gmail.comRRIDs and where they fit into known standards such as the ARRIVE 2.0 guidelines
May 16 – Session 2 (2:00 pm – 3:00 pm) Artificial Intelligence (AI) Application in Genetics and Epigenomics Carl Lin and Sara Mostafavi, Chairs
TimeFirst NameLast NameEmailAbstract Title
2:00CarlLinzlin@mclean.harvard.eduHistory and Application of Artificial Intelligence: Its Turn for Genomics
2:00SaraMostafavisaramos@cs.washington.eduSequence-based deep learning models for predicting molecular phenotypes
2:15HongyangLiHongyang.Li@ibm.comAsymmetric Predictive Relationships Across Histone Modifications
2:30AndreasPfenningapfenning@cmu.eduFine-mapping candidate neuropsychiatric regulatory variants using cell type-aware comparative genomics
May – 16 Session 3 (4:30 pm – 5:20 pm) - Short Talk Presentations
TimeFirst NameLast NameEmailAbstract Title
4:30AlexanderHatoumashatoum@wustl.eduMultivariate genome-wide assocation meta-analysis of 1 million subjects identifies loci underlying multiple substance use disorders
4:40JeffreyHatfieldjshatfi@g.clemson.eduCocaine Preference in the Drosophila melanogaster Genetic Reference Panel
4:50ChelsieBenca-Bachmanchelsie.benca@emory.eduAdditive Genetic and Interactive Effects on Alcohol Problems and Traumatic Experiences Among African Americans
4:55Xiufang (Nadine)Guoxguo@mail.ucf.eduDevelopment of an iPSC-preBötC neuron opiate overdose and recovery multi-organ platform
5:00JenniferKelschenbachjennifer.kelschenbach@mssm.eduMorphine dependence accelerates HIV-associated neurocognitive impairment in EcoHIV infected mice
5:05SalmaMajidmajidsn@nih.govRecurrent and non-recurrent copy number variants in American Indian tribes with substance use disorders
5:10FreddysonMartinez-Riverafreddyson.martinez-rivera@mssm.eduCellular and transcriptional contributions of the nucleus accumbens in transferring extinction-based memories
5:15EvaristusNwuliaenwulia@howard.eduLinking Cannabis Use Disorder, Long-noncoding RNA and Olfactory Structure and Function
May 17 – Session 4 (9:00 am – 10:15 am) - Non-Cannonical regulation of gene-expression by drugs with addictive properties Elizabeth Heller and Zhzhu Zhang, Chairs
TimeFirst NameLast NameEmailAbstract Title
9:00ElizabethHellereheller@pennmedicine.upenn.eduCocaine regulation of alternative splicing via changes in histone postranslational modifications.
9:15ZijunWangzjwang@ku.eduDNA damage and repair processes are involved in opioid addiction
9:30ZhuzhuZhangzhuzhuzhang@uchicago.eduEpigenomic remodeling at single cell resolution in cocaine self-administration in mice
9:45BaDoiPhanbadoi.phan@pitt.eduWhole-animal massively parallel reporter assay dissects the region-specific transcriptional impact of human addiction genetic variants
May 17 – Session 5 (1:15 pm – 2:30 pm) - The Role of Behavioral Undercontrol in Mediating Genetic Risk for Substance Use Disorders Abraham Palmer and Danielle Dick, Chairs
TimeFirst NameLast NameEmailAbstract Title
1:15HollyPooreholly.poore@rutgers.eduCharacterizing the Genetic Overlap between Externalizing Phenotypes and Substance Use Disorders
1:30SandraSanchez-Roigesanchezroige@ucsd.eduCADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice
1:45HudaAkilakil@umich.eduSelectively Breeding for Temperament and Vulnerability to Addiction: A Genetic, Genomic and Neural Characterization of Behavioral Undercontrol and Overcontrol.
2:00MichaelSheldonmichael.sheldon@sampled.comBiobanking as a Foundational Component of NIH Research: The NIDA Center for Genetic Studies Provides A Critical Resource for Research into the Genetics and Epigenetics of Substance Abuse
May – 17 Session 6 (4:00 pm – 4:50 pm) - Short Talk Presentations
TimeFirst NameLast NameEmailAbstract Title
4:00AmritKoiralaamrit.koirala@bcm.eduDeconvolution of microRNA/mRNA Networks in Brain Regions Impacted by Cocaine Use Disorder to Develop a Mechanistic Biosignature for Pharmacotherapy Response
4:10VivekPhilipVivek.Philip@jax.orgEnumeration and visualization of differential gene co-expression response to cocaine
4:20JanitzaMontalvo-Ortizjanitza.montalvo-ortiz@yale.eduDeciphering the role of DNA hydroxymethylation in substance use disorders
4:25MadhurBainSinghsinghm18@vcu.eduExamining Bidirectional Causal Effects between Smoking and DNA Methylation using Epigenetic Mendelian Randomization Analyses
4:30AlyssaWilsonalyssa.wilson@mssm.eduIdentifying Cell-Type-Specific Transcriptional Changes in Midbrain in the Context of Substance Use Disorder and Long-Term HIV Infection: A Cohort Study at the Manhattan HIV Brain Bank
4:35FrancescaTeleseftelese@health.ucsd.eduAnalysis of single nuclei RNA-seq from the nucleus accumbens of heterozygous reeler mice exposed to THC during adolescence suggests a link between THC exposure, Reelin signaling, and vulnerability to human psychiatric disorders
4:40JaredBagleyjbagley@binghamton.eduNeuron navigator 1 regulates the self-administration of cocaine
4:45LauraSabaLaura.Saba@cuanschutz.eduMulti-omic single nuclei data provide insight into the cellular origin of whole brain coexpression patterns related to Oprm1
May 16 – Poster Session A (11:10 am – 12:40 pm)
Poster #First NameLast NameEmailAbstract Title
1ArpanaAgrawalarpana@wustl.eduThe Psychiatric Genomics Consortium Substance Use Disorders Working Group (PGC-SUD): An Update
2SchahramAkbarianschahram.akbarian@mssm.eduSingle Nucleus Transcriptomic Profiling of Human Ventral Midbrain Reveals Widespread Activation of Multiple Glial Subtype
3MuhammadArshadmuhammadwaqar.arshad@yale.eduSubstance Abuse in Pakistan: Clinical Issues and Research Opportunities
4Bao-ZhuYangbao-zhu.yang@yale.eduInter-Linking the Developmental Brain Transcriptome and GWAS Risk Variants Revealed Neural Circuits Prognostic of Nicotine Use Severity
5DavidAshbrookdashbrook@UTHSC.eduGood wine and old data get better with age: New insights on gene-by-environment effects of drugs of abuse in mice using GeneNetwork.org
6ChristopherBakerchristopher.baker@jax.orgGenetic variation influences cell specific cis-regulatory landscape in the mouse striatum
7MadelynBakermrb4002@med.cornell.eduEpigenetic representation of cocaine-context association in the dorsal dentate gyrus of male mice
8BritahnyBaskinbritty@bu.eduPremorbid addiction model traits and cocaine stimulant sensitivity in spontaneously hypertensive rat (SHR) substrains
9JacobBeierleJacob.Beierle@jax.orgA high-throughput machine vision-based univariate scale for pain and analgesia in mice
10AritraBhattacherjeewritetoab@gmail.comDecoding molecular organization of the brain reward circuit for understanding mechanisms of drug addiction
11ChuanBichuan.bi@som.umaryland.eduMultivariate Mediation Analysis of Genetic Variants, Brain Connectome and Nicotine Addiction
12FatahKashanchifkashanc@gmu.eduRetroviral infection of human neurospheres and use of stem cell EVs to repair cellular damage
13KaseyBridakbrida@uab.eduReelin protein marks cocaine-sensitive Drd1+ medium spiny neurons and modulates medium spiny neuron physiology and behavioral response to cocaine
14RussellBrownBROWN1@mail.etsu.eduAnalysis of the enhanced rewarding effects of nicotine and underlying neuroplasticity mechanisms in a heritable model of drug abuse vulnerability in psychosis
15CalebBrownecaleb.browne@mssm.eduTranscriptome profiling of the brain’s reward circuitry in heroin self-administration identifies a ventral hippocampus gene network related to relapse susceptibility
16EdwardBrowneepbrowne@email.unc.eduDefining the impact of cannabis use on immune cell phenotypes and the latent viral reservoir in people with HIV.
17CamronBryantcamron@bu.eduSpectrotemporal USV profiles during neonatal opioid withdrawal in FVB substrains, Zhx2-edited BALB/c substrains, and outbred CFW mice
18JasonBubierJason.Bubier@jax.orgA Tale of Two Opioids: The Genetics of Opioid Induced Respiratory Depression in Response to Fentanyl and Morphine in Mice.
19BelleBuzzibuzzib@vcu.eduNicotine reward and preference in C57BL/6J and C57BL/6N mouse strains
20Jean LudCadetjcadet@intra.nida.nih.govCompulsive methamphetamine intake and abstinence in the presence of punishment are associated with differential hydroxymethylation of miRNAs in the rat nucleus accumbens
21CaliCalarcoccalarco@som.umaryland.eduMitochondrial gene ontology pathways and transcriptional regulators impacted by cocaine in C57Bl/6 mice
22RianneCampbellrcampbell@som.umaryland.eduBaseline Characterizations of Novel D1R-CRISPRa and A2A-CRISPRa Mouse Lines
23JavanCarterJCarter@rti.orgIdentifying novel genes and pathways associated with opioid overdose death via meta-analysis of differential gene expression.
24SamanthaCheeksscheeks@uci.eduCannabidiol Attenuates Nicotine Self-Administration and Withdrawal Symptomology in Mice
25JixinChenchenj@ohio.eduA single-molecule FRET data fitting package for DNA folding kinetic study
26YongChenchenyong@rowan.eduInferring Memory-related Regulatory Modules in Engram Cells by Deep-learning and scRNA-seq Data
27OliviaCorradincorradin@wi.mit.eduCase-specific epigenetic alterations converge on key genes linked to opioid overdose
28DanielWoodwoodda@musc.eduHDAC5 intrinsic enzymatic activity limits drug-seeking behavior
29SantiagoCuestasantiago.cuesta@rutgers.eduGut Microbiota Composition Modulates Cocaine-Induced Neurobehavioral Plasticity
30EamonnDuffyEamonn.Duffy@colorado.eduCharacterization of thermal and mechanical sensitivity in select strains of the Hybrid Rat Diversity Panel
31SorenEmersonsoren.d.emerson@vanderbilt.eduLysine acetyltransferase KAT2a is a novel cocaine-recruited epigenetic regulator in the nucleus accumbens
32DanFabrisdan.fabris@uconn.eduInvestigating epitranscriptomic communications between HIV-1 infection and neuromodulator response in different CNS cells
33FangFangffang@rti.orgA DNA methylation-based classifier for lifetime cannabis use
34J. AdamFieldsjafields@health.ucsd.eduEffects of cannabinoids on phenotype of patient monocyte-derived macrophages vary by cannabis use patterns
35ZoeFigueroazoe.figueroa@email.ucr.eduAstrocytic contributions to chronic methamphetamine induced neuroinflammation and disease
36PrescillaGarcia-Trevizopjg5435@psu.eduLong-term Effects of Adolescent Nicotine Exposure on Sensitivity and Cotinine in the Diversity Outbred Mouse Population.
37PaigeLemenplemen1@uthsc.eduAdolescent Social Isolation Increases Vulnerability to Voluntary Opioid Consumption in Adulthood in Rats
38MuditTyagiMudit.Tyagi@jefferson.eduCocaine by co-stimulating NF-kB, NFAT, and AP-1 enhances CD4+ T-cells metabolism; thus, sensitizes partially active cells for HIV infection
39Min-AeSongsong.991@osu.eduEpigenetic Aging in the Human Lung: Focus on Smoking and Vaping
May 16 – Poster Session B (3:00 pm – 4:30 pm)
Poster #First NameLast NameEmailAbstract Title
1VivekSwarupvswarup@uci.eduInvestigating multi-omic Mechanisms Underlying Opioid Addiction Vulnerability: A Multi-Omics Study
2ColinHodgkinsonchodg@mail.nih.govAlcohol and stress additively accelerate epigenetic cellular age
3RodrigoGrassi-Oliveirarogo@clin.au.dkExposomics of Cocaine Use Disorder: A new paradigm to study the impact of environmental exposures in Substance Use Disorders
4BenjaminGrissomBGrissom@som.umaryland.eduHeroin-induced genomic regulation of ventral pallidum and nucleus accumbens neuron subtypes
5PetarGrozdanovpetar.grozdanov@ttuhsc.eduThe role of alternative polyadenylation in a TLR3-mediated mouse model of escalated alcohol consumption
6HongshengGuihgui1@hfhs.orgBivariate relationship between opioid use disorder and suicide attempts despite mental health
7MeganHagenauerhagenaue@umich.eduThe Brain Data Alchemy Project: Teaching Research Reproducibility and Discovery Science While Mining Gold from Archived Genomics Data
8NikhilHajirnisnhajirnis@som.umaryland.eduEpigenomic editing of nucleus accumbens neuron subtypes using the CRISPR-Cas12f derived system
9PeterHamiltonpeter.hamilton@vcuhealth.orgSynthetic transcription factors, delivered to mouse nucleus accumbens, dysregulate drug-specific transcription and behaviors
10ShuanglinHaoshao@med.miami.eduLoss of Sirt3 induced by HIV gp120 with morphine in neuropathic pain, is mediated by H3K27me3 in the spinal cord
11EmilyHartwellEmily.Hartwell@pennmedicine.upenn.eduPerformance of a polygenic risk score for depression in a deeply phenotyped sample
12YingHeyhe@midwestern.eduEpigenetic regulation of opioid dependence by microRNAs
13ElaineHebda-Bauerhebda@med.umich.eduBioenergetic-Related Gene Expression in the Hippocampus Predicts Internalizing vs. Externalizing Behavior in a F2 Cross of Selectively-Bred Rats
14Ming-FenHoho.mingfen@mayo.eduEpigenetic Regulation of GABA Catabolism in iPSC-derived Neurons: the Role of FGF21
15LeanneHoltleanne.holt@mssm.eduElucidation of the astrocyte-specific transcriptome following cocaine self-administration
16SpencerHuggettshuggett91@gmail.comIn Silico Genetic & Neuromolecular Drug Repurposing for Opioid Use Disorder
17AlvinJefferyalvin.d.jeffery@vanderbilt.eduDetecting Opioid Use Disorders in the Electronic Health Record to Support Genetic Studies: Adaptation of the Addiction Behaviors Checklist
18ThomasJhoujhou@musc.eduHeritability and GWAS analyses of punishment sensitivity and cocaine avoidance in HS rats
19KanShaokshao@indiana.eduDose-Response Analysis to Advance Gene and Pathway Identification for Risk Estimation of Substance Use Disorder
20GuochunJiangjianggc@gmail.comEpigenetic regulation of a persistent HIV reservoir in human brain myeloid cells despite durable ART
21EmmaJohnsonemma.c.johnson@wustl.eduCross-disorder analysis of cannabis use disorder and schizophrenia reveals convergent and divergent genetic influences
22YonwooJungyonwoo.jung@nih.govMitochondrial Dysfunction and Oxidative Stress: Conserved Functional Phenotypes in Cocaine Addiction across Multiple Brain Regions
23MarcusKaulMarcus.Kaul@medsch.ucr.eduMethamphetamine promotes in macrophages stimulated with LTR mimic ssRNA40 expression of HIV-regulating lncRNA HEAL and pro-inflammatory factors but suppresses the interferon response
24PanjunKimpkim11@uthsc.edu3D Chromatin Interaction Data Facilitates de novo Genome Assembly and Identifies Promoter-Enhancer Interaction in the PFC of Rats
25CassandraKooikerckooiker@uci.eduGenetic tagging uncovers a role for the thalamic paraventricular nucleus in mediating aberrant reward behaviors following adverse experiences early in life
26BrittanyKuhnkuhnb@musc.eduNetwork-based clustering approach models multi-symptomatic opioid use disorder vulnerability
27AshleyKumaravkumar@ucsd.eduTranscriptional initiation profiling of primary brain cells to study stimulus-dependent enhancer activity
28ValeriaLallaivlallai@uci.eduTHC- and Nicotine-Induced Changes in Central and Peripheral Extracellular Vesicle RNA Cargo
29EvaLancasterEva.Lancaster@vcuhealth.orgExamining polygenic risk score by environment interaction on the relationship between interpersonal violence exposure and alcohol use in an ancestrally diverse college cohort
30PaigeLemenplemen1@uthsc.eduOpiate responses are controlled by interactions of Oprm1 and Fgf12 loci in rodents: Correspondence to human GWAS findings
31MichaelLeonemleone@andrew.cmu.eduSpinal cord neuronal subtypes conserved across species are genetically implicated in chronic pain disorders
32DongmeiLiDongmei_Li@urmc.rochester.eduLongitudinal changes in expression profile of urine exosomal epigenetic microRNAs in exclusive electronic cigarette adult users
33XiaoyuLiangxiaoyuliang@msu.eduDNA Methylation-Based Telomere Length Is Associated With HIV Frailty and All-Cause Mortality
34CarlLitifclitif@uwyo.eduIdentifying reward-specific transcriptomes underlying polyreward seeking ensembles in the nucleus accumbens core and prelimbic cortex
35ShirelleLiuliu00459@umn.eduDifferential gene expression and epigenetic regulation in the medial prefrontal cortex of rats showing vulnerability to opioid addiction
36JenniferLoftisloftisj@ohsu.eduPlasma extracellular vesicles and their miRNA cargo as biosignatures for neuropsychiatric impairments in methamphetamine use disorders
37RyanLoganRyan.Logan@umassmed.eduElevated DNA damage and inflammatory markers in specific striatal cell types associated with opioid use disorder using single nuclei RNAseq in human postmortem brain
38FalkLohofffalk.lohoff@nih.govAdditive Effects of Stress and Alcohol on Epigenetic Aging
39SamikkannuThangavelthangavel@tamu.eduEpigenetic signature of N-terminal acetyltransferases role in HIV-Neuropathogenesis
May 17 – Poster Session C (10:15 am – 11:45 am)
Poster #First NameLast NameEmailAbstract Title
1AliceMinAlice.Min@mountsinai.orgA novel humanized mouse model to track active and latent CNS HIV-1 infection and to test therapeutic interventions
2LuisAraujoldearaujo@unimelb.edu.auPower, measurement error and pleiotropy robustness in twin design extensions to Mendelian randomization
3PaigeLemenplemen1@uthsc.eduOxycodone oral self-administration in inbred rats identifies different patterns of vulnerability
4AndrewLombardianlo5057@colorado.eduRole of GSCAN Identified Genes in the Astrocytic Response to Nicotine
5ShahrdadLotfipourshahrdadlotfipour@me.comFunctional Role of a Human 3'UTR Alpha6 Nicotinic Receptor Polymorphism (rs2304297) in Adolescent Substance Use
6QingLulucienq@ufl.eduKernel Neural Networks for Analyzing Large-scale Substance Use Disorders Genetic Data
7WilliamLynchwlynch@bu.eduValidating Zhx2 in oxycodone metabolite (oxymorphone) brain concentration and behavior via reciprocal gene editing and viral manipulation of gene expression in BALB/c substrains
8TianzhouMatma0929@umd.eduBayesian indicator variable selection for multivariate response with application to multi-trait fine mapping
9ScottMackeymsmackey@uvm.comENIGMA Addiction: Neuroimaging Biotypes Supported by Gene Enrichment Analysis
10RajtarunMadangopalrajtarun.madangopal@nih.govIn vivo labeling and molecular characterization of cocaine memory-specific active neurons using the photo-convertible calcium integrator CaMPARI2
11TravisMallardtmallard@mgh.harvard.eduLimited evidence for a general dimension of impulsivity across genomic, transcriptomic, and neuroanatomical levels of analysis
12LisaMaturinlmaturin@health.ucsd.eduThe Addiction Biobanks: : Three repositories of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of cocaine, oxycodone, and alcohol self-administration.
13NicolaMicalinicola.micali@yale.eduThe effect of prenatal cannabinoid exposure on developing primate cerebrum
14MelyssaMintomminto@rti.orgTissue-Specific DNA Methylation Signatures of Alcohol Use Disorder in Human Brain
15SuzanneMitchellmitchesu@ohsu.eduLessons learned in creating selected lines for high and low delay discounting
16MaheshMohanmmohan@txbiomed.orgDelta-9-Tetrahydrocannabinol:Cannabidiol combination counteracts colonic epithelial and blood-brain barrier dysfunction in SIV-infected rhesus macaques on combination anti-retroviral therapy
17KaterynaMurlanovakmurlano@buffalo.eduLoss of astrocytic mu opioid receptors exacerbates aversion associated with morphine withdrawal in mice: a role for mitochondrial respiration
18RandyNelsonrandy.nelson@hsc.wvu.eduLight at Night Drives Sex-Specific Increases in Fentanyl Reward-Related Behaviors
19AbrahamPalmeraap@ucsd.eduRATTACA: a new paradigm for examining genetic correlations in outbred rats
20RohanPalmerRohan.Palmer@Emory.eduConserved Co-expression Signatures of Chronic Alcohol Consumption across Species
21ClarissaParkercparker@middlebury.eduGenetic variation and heritability of negative affective withdrawal from cocaine in the CC/DO founder mouse strains
22GitaPathakgita.pathak@yale.eduEpigenetic profiles of latent classes for polysubstance use disorder
23JackPatteejack.pattee@cuanschutz.eduAdjusting for cis-regulatory variation in gene expression data can improve biological network analysis in model organisms
24QianPengqpeng@scripps.eduPleiotropic Loci for Cannabis Use Disorder Severity in Multi-Ancestry High-Risk Populations
25IngaPeteringa.peter@mssm.eduHigh Content Transcriptomics Screen to Explore Pathway Crosstalk between Morphine and Antiretroviral Therapy Drug Combinations
26AmandaGentryAmanda.Gentry@vcuhealth.orgMachine Learning to Predict Alcohol Consumption From Blood-Based Biomarkers
27RobertPhillipsrphill3@uab.eduDistinct subpopulations of D1 medium spiny neurons exhibit unique transcriptional responsiveness to cocaine
28BryanQuachbquach@rti.orgTranscriptome-wide association study for frequent cocaine use identifies gene dysregulation in CD4+ T cells linked to immune response and cancer pathways
29FatirQureshiqureshi@wi.mit.eduChromatin QTL analysis identifies genetic variants that influence H3K27ac in opioid overdose cases.
30YumnaRahmanrahmany@vcu.eduInfluence of Genotype and Sex on Oral Nicotine Consumption in Founder Strains of Diversity Outbred Mice
31HannahRamcharanhkramcha@wi.mit.eduVariation in Gene Regulation Across Neurons from Seven Different Brain Regions
32DavidRootDavid.Root@Colorado.EDUVentral tegmental area glutamate neurons establish a mu-opioid receptor gated circuit to mesolimbic dopamine neurons and regulate opioid-seeking behavior
33AdrianRothenfluhadrian.rothenfluh@hsc.utah.eduBitter gustatory perception protects Drosophila from escalating cocaine consumption preference.
34ErickSaldesesaldes@miners.utep.eduNovel genetic loci interacting with social environment for dysfunctional inhibitory control
35DanielleSambodanielle.sambo@nih.govDifferential effects of prenatal alcohol exposure on brain growth in a mouse model for fetal alcohol spectrum disorder
36YasmineSamiyns@wi.mit.eduDifferentially expressed genes in Opioid Use Disorder are enriched amongst genes with brain region specific regulatory activity
37JiangwenSunjsun@odu.eduTraining Deep Neural Networks Predicting DNA Methylation to Elucidate Genetic Associations in Substance Use Disorders
May 17 – Poster Session D (2:30 pm – 4:00 pm)
Poster #First NameLast NameEmailAbstract Title
1SandraSanchez-Roigesanchezroige@ucsd.eduMulti-ancestry meta-analysis of tobacco use disorder based on electronic health record data prioritizes novel candidate risk genes and reveals associations with numerous health outcomes
2PietroSannapsanna@scripps.eduUnraveling the interplay between neuroHIV and substance abuse with systems biology to shed light on novel druggable targets.
3KatherineSavellkatherine.savell@nih.govDevelopment of multipleXed Population Selection and Enrichment single nuclei RNA-sequencing (XPoSE-seq) to characterize neuronal ensembles in cocaine relapse
4Randal AlexSerafinialex.serafini@icahn.mssm.eduNovel Oxycodone Paradigm Highlights Mesocorticolimbic Mechanisms Underpinning Withdrawal-associated Behaviors with and without Chronic Pain
5MaritSolheim-Wittmarit@alpha-element.comResilience, resourcefulness and self-leadership: Evaluation of a self-management program and novel conceptual framework of Vitality Type patterns in behavior and communication
6AkhilSharmaakhilsharma@wayne.eduComparing Responses of the Nucleus Accumbens and Ammon’s Horn to Methamphetamine Neurotoxicity
7AliaksandraSikirzhytskayasikirzha@mailbox.sc.eduAI-based mining of biomedical literature: Applications for the drug repurposing for the treatment of HIV-Associated Neurocognitive Disorder.
8OmarSoler-Cedeñoomar.soler-cedeno@nih.govBrain CB2 receptor: a new therapeutic target for treating opioid use disorders, major findings from a new CB2-KO-eGFP reporter mouse line
9SheetalSreeramsxs2286@case.eduInduced pluripotent stem cells (iPSCs) derived cerebral organoids to model the impact of methamphetamine exposure on HIV latency.
10ChaitanyaSrinivasancsriniv1@cs.cmu.eduRegulatory variation in D1/D2 co-expressing medium spiny neurons is suggested to predispose addiction-related traits
11JerryStitzelstitzel@colorado.eduQTL Mapping of Genetic Modifiers of Oral Nicotine Consumption in Chrna5 Null Mutant Mice
12KyleSullivansullivanka@ornl.govHeroin overdose-associated transcriptional and epigenetic alterations in the orbitofrontal cortex concentrate in GABAergic interneurons and provide insight into cell type-specific regulatory response
13JiangwenSunjsun@odu.eduAnnotating Genetic Variants by Training Deep Neural Networks to Predict Multiple Epigenomic Events in Brain via Effective Multi-task Learning
14MakotoTaniguchiTaniguch@musc.eduA long non-coding enhancer RNA regulates NPAS4 in the NAc to control drug reward-conditioned behavior
15LisaTarantinolisat@med.unc.eduGenetic mapping of initial locomotor sensitivity to cocaine in two divergent Collaborative Cross inbred mouse strains
16IrisTitosiris.titos@utah.eduMechanisms of diet modulating experience-dependent amphetamine preference
17JillTurnerJill.Turner@uky.eduPhenotyping Individual Differences in Escalation of Fentanyl Self-Administration in Sprague-Dawley Rats. 
18DavidVandenberghdjv4@psu.eduHyper-Variable Number of Tandem Repeats in Intron 8 of the Human Dopamine Transporter Gene (SLC6A3)
19ArvindVenkataramanavenkata@uw.eduA genome-wide association study of methamphetamine use among people with HIV
20ThiagoViolathiago.wendt.viola@gmail.comThe effects of maternal cocaine use during pregnancy in pediatric epigenetic clocks and methylation risk scores in humans
21LuWanglu.wang.lw763@yale.eduWhole-exome Sequencing Study of Alcohol Use Disorder in 1,668 European Americans and 1,547 African Americans
22XuWangxuwang@temple.eduActivation of Toll-like receptor 3 by poly (I:C) inhibits HIV infection of human iPSC-derived microglia
23TaoWuTao.Wu@bcm.eduQuantitative Profiling of DNA N6-methyladenine at single-base resolution with NAME-Seq
24SarahNealsjneal@mdanderson.orgA Baboon Research Resource for Use in Studies on Substance Abuse Disorders
25JulieWhitejdwhite@rti.orgIntegration of DNA methylation and RNA sequencing elucidates differential gene regulation associated with alcohol use disorder in the human brain
26AnastasiaWilliamsawill57@gmu.eduThe effects of cannabidiol and HU308 on viral transcription in HIV-1 infected cells and resulting extracellular vesicle release
27CarynWilliscdwillis@rti.orgGene Correlation Networks Replication Analysis Across Studies to Identify Top Candidate Gene Targets in Opioid Use Disorder
28MichaelWyattwyatt@cop.sc.eduDrug Repurposing for the prevention of dementia among people living with human immunodeficiency virus: A focus on the renin-angiotensin system
29Rong-GuangXuroxu@bwh.harvard.eduHow histone post-translational modifications impact nucleosome structure and accessibility: A molecular dynamics study
30GalYadidyadidg@mail.biu.ac.ilUse of psychedelic and epigenetic substances as novel approaches for treating substance addiction – hope or hype?
31ZhenyaoYezye@som.umaryland.eduPleiotropic genes for resting-state brain functional connectivity and nicotine addiction
32HangZhouhang.zhou@yale.eduMendelian Randomization Analysis of the Effects of Alcohol Use on Cancer Risk
33YanjiaoZhouyazhou@uchc.eduGenetic control of the microbiome and bile acids to influence addiction-related behaviors
34LauraHackhack@stanford.eduKetamine’s Acute Effects on Negative Brain States are Mediated through Distinct Altered States in Humans
35YanchaoPanhanyou@umich.eduA revamped rat reference genome improves the discovery of genetic diversity of laboratory rats
Abstracts From Those Unavailable to Present
First NameLast NameEmailAbstract Title
Li-ShiunChenli-shiun@wustl.eduRoadmap for translating genomic evidence to clinical interventions for prevention and treatment
DitteDemontisditte@biomed.au.dkElucidating genetic risk factors for externalizing and internalizing alcohol use disorder behaviors through large-scale cross-disorder GWAS
DesmondSmithDSmith@mednet.ucla.eduCocaine and cannabis: a joint dependence revealed by a longitudinal genetic study in mice
Abstracts and Agenda from April/May 2022 meeting

Presentations

April 27th - Session 1 (11 am - 12:30 pm) Data Science in HBCUs: Leveraging Scientific Expertise to Tackle the Genetics of Addiction
TimeName and EmailAbstract
11:00William SoutherlandThe Howard University Center of Applied Data Science and Analytics (CADSA)
11:15Anil ShankerGenomics and Health Equity Research: Current Challenges and Opportunities
11:30Jennifer TroyerHuman Heredity and Health in Africa (H3Africa)
11:45Adaku OfoegbuThe Role of Phase II Metabolic Enzymes and Drug Transporters on Buprenorphine Pharmacogenomics in Opioid Use Disorder Management
12:00Evaristus NwuliaComparative Response to Alcohol in Individuals with ADH1B*1 and ADH1B*3 Polymorphisms
April 27th - Session 2 (1 pm - 2:30 pm)Tools and Methods to Visualize Genomic Signals in GWAS
TimeName and EmailAbstract
1:00Xiaoyu LiangA Mediating Role for Epigenetic Aging in the Relationship Between People Who Inject Drugs with HCV and All-Cause Mortality
1:15Luis Castro-de-AraujoBidirectional causal modeling with instrumental variables and data from relatives
1:30Brittany KuhnNetwork-based clustering approach models multi-symptomatic opioid use disorder vulnerability
1:45Kyle SullivanMulti-omic network analysis identifies key neurobiological pathways in opioid addiction
2:00Andy ChenFunctional Screening of 3’-UTR Variants Combined with Genome-wide Association Identifies Causal Regulatory Mechanisms Impacting Alcohol Consumption and Alcohol Use Disorder
May 4th - Session 3 (11 am - 12 noon)Can Increasing Diversity Lead to Deeper Understanding of Addiction?
TimeName and EmailAbstract
11:00Xingyan WangTrans-Ancestry Fine-Mapping and Ancestry Heterogeneity Analysis for Smoking & Drinking Addiction Phenotypes using 3.4 Million Individuals with Diverse Ancestries
11:15Alexia HatoumCross-Ancestral Genome-wide analysis of Broad Addiction Vulnerability Leads to Additional Insight Over European GWAS Alone
11:30Hang ZhouAdvanced genetic study of problematic alcohol use in > 1 million subjects from multiple populations
May 4th - Session 4 (12:30 pm - 2 pm)Leveraging Multi-Species Analyses
TimeName and EmailAbstract
12:30Andreas PfenningWhat can bats, capybaras, and tree shrews tell us about the genetic basis of addiction?
12:45Brenda Cabrera-MendozaCross-tissue Evaluation of Epigenetic Clocks in Substance Use Disorder
1:00Abraham PalmerComparing polygenic signals across species
1:15Rohan PalmerMolecular Brain Signatures of Chronic Alcohol Use Across Species
1:30Robyn BallIntegrating past, present and future mouse and human population genetics of addiction using multi-trait meta-analyses to identify conserved human polysubstance use genes
May 4th - Session 5 (2 pm - 3 pm)Understanding Comorbidities and Addiction
TimeName and EmailAbstract
2:00Bonnie AlberrySex-specific prefrontal cortex gene networks moderate the effect of early adversity on childhood behavior and adult substance abuse
2:15Amelia CuarentaThe effect of resource scarcity early in life on the rat basolateral amygdala transcriptome
2:30Ditte DemontisGenome-wide cross-disorder analysis of ADHD and cannabis use disorder and cannabis use
May 11th - Session 6 (11:15 am - 12:30 pm)Epigenetics, Gene Regulation and the SUD Brain
TimeName and EmailAbstract
11:15Consuelo Walss-BassPostmortem brain multi-omic profiling and vertical data integration in cocaine and opioid use disorder
11:30Jessica ChildsDominant negative of transcription factor NR4A2 in medial habenula attenuates reinstatement of cocaine self-administration in mice
11:45Delaney FischerInvestigating the transcriptomic and epigenomic profile of the mouse striatum following cocaine exposure
12:00Erin CalipariHistone acetyltransferase KAT2A is a critical epigenetic regulator of cocaine responses in the nucleus accumbens
May 11th - Session 7 (1 pm - 2:15 pm)The Power of Single Cell Studies
TimeName and EmailAbstract
1:00Zhuzhu ZhangSingle-cell characterization of epigenomic remodeling in cocaine self-administration in mice
1:15Ming-Fen HoSingle cell transcriptomics reveals distinct transcriptional response to oxycodone and buprenorphine by iPSC-derived brain organoids from patients with opioid use disorder
1:30Jessica ZhouComputational analysis of snATAC-seq from amygdalae reveals cell type-specific chromatin regions associated with cocaine addiction
1:45BaDoi PhanSingle cell multi-omics of the rhesus macaque striatum reveal regulatory mechanisms underlying the genetic basis of addiction

Posters

April 27th - Poster Session A (3 pm to 4:15 pm)
Poster #Name and EmailAbstract
1William SoutherlandThe Howard University Center of Applied Data Science and Analytics (CADSA)
2Anil ShankerGenomics and Health Equity Research: Current Challenges and Opportunities
3Jennifer TroyerHuman Heredity and Health in Africa (H3Africa)
4Andy ChenFunctional Screening of 3’-UTR Variants Combined with Genome-wide Association Identifies Causal Regulatory Mechanisms Impacting Alcohol Consumption and Alcohol Use Disorder
5Brenda Cabrera-MendozaCross-tissue Evaluation of Epigenetic Clocks in Substance Use Disorder
6Robyn BallIntegrating past, present and future mouse and human population genetics of addiction using multi-trait meta-analyses to identify conserved human polysubstance use genes
7Bonnie AlberrySex-specific prefrontal cortex gene networks moderate the effect of early adversity on childhood behavior and adult substance abuse
8Soren EmersonA history of cocaine self-administration and withdrawal reprograms the transcriptional response to acute cocaine in the NaC
9Lauren BaileyOrbitofrontal And Accumbal Dopamine Function In Bxd Mouse Strains Selected For High Or Low Impulsivity
10Collin TeagueCircuit-wide gene network analysis reveals a role for phosphodiesterase enzymes in cocaine addiction
11Ashita BatraPolygenic Risk for High Fasting Insulin Predicts Childhood Impulsivity and Adulthood Substance Dependence in Response to Early Adversity
12Jacob BeierleA BALB/c reduced complexity cross identifies Zhx2 as a candidate gene underlying oxymorphone brain concentration and state-dependent learning of oxycodone reward
13Andrew BergenPredicted Nicotine Biomarkers and Translational Research in Multiethnic Populations
14Rigel MahmoodDimension Reduction and Cluster Analysis of Mouse Microbiome Data for Understanding Heterogeneity of Addiction
15Kasey BridaReelin protein marks cocaine-sensitive Drd1+ medium spiny neurons and modulates the transcriptional and physiological response to dopamine
16Emily BrocatoAdolescent Binge Ethanol Induces Dysregulation of H3K36me3 at Dendritic Spine, Synaptic Assembly, and Memory-related Genes
17Caleb BrowneTranscriptome profiling of the brain’s reward circuitry in heroin self-administration identifies a ventral hippocampus gene network related to relapse susceptibility
18Jason BubierA tale of two opioids: The genetics of fentanyl and morphine lethality in mice
19Katerina Zorina-LichenwalterCommon factors across chronic pain conditions in the UK Biobank
20Cali CalarcoMitochondrial gene ontology pathways and transcriptional regulators impacted by cocaine self-administration in C57Bl/6 mice
21Poster Presenter Unavailable
22Rianne CampbellMolecular Profiling of Mouse Ventral Pallidum Projection Neurons
23Nazzareno CannellaNIH Heterogeneous Stock rats trained to heroin self-administration show heterogeneous response to the anti-addictive effects of the MOP/NOP agonist Cebranopadol
24Megan CarnesSmoking-informed methylation QTLs in human nucleus accumbens
25Subhash ChandRole of Methamphetamine Induced Extracellular Vesicles in HIV Neuropathogenesis and Toxicity
April 27th - Poster Session B (4:15 pm to 5:30 pm)
Poster #Name and EmailAbstract
26Li-Shiun ChenPrecision Tobacco Treatment: Genetic risk scores and biomarkers
27Alexia HatoumCross-Ancestral Genome-wide analysis of Broad Addiction Vulnerability Leads to Additional Insight Over European GWAS Alone
28Amelia CuarentaThe effect of resource scarcity early in life on the rat basolateral amygdala transcriptome
29Ditte DemontisGenome-wide cross-disorder analysis of ADHD and cannabis use disorder and cannabis use
30Consuelo Walss-BassPostmortem brain multi-omic profiling and vertical data integration in cocaine and opioid use disorder
31Jessica ChildsDominant negative of transcription factor NR4A2 in medial habenula attenuates reinstatement of cocaine self-administration in mice
32Delaney FischerInvestigating the transcriptomic and epigenomic profile of the mouse striatum following cocaine exposure
33Youshu ChengGenetic variants influence DNA methylation on Cocaine Use in the Veterans Aging Study Cohort
34Eric ChoiCell Subtype Specific Role of Nab2 in Cocaine Seeking Behavior
35Richard CristSingle nucleus transcriptomic analysis of the nucleus accumbens reveals distinct cell type-specific patterns of gene expression associated with the escalation of morphine intake in male rats
36Renata CupertinoNeural Correlates of Polygenic Risk Scores for Problematic Substance Use in Adolescents
37Poster Presenter Unavailable
38Tristan de JongGenetic variation within 90 inbred rat strains mapped to mRatBN7.2
39Eamonn DuffyCharacterization of oxycodone use disorder phenotypes in select rat strains of the Hybrid Rat Diversity Panel
40Kit ElamPolygenic Predisposition for Educational Attainment Predicts Self and Partner Education Attainment and Alcohol Use Frequency
41Zachary EvenGenome-Wide Analysis of Methylome in the Mouse Brain Reveals Epigenetic Regulation of Alcohol Use Disorder
42Fang FangEpigenome-wide association meta-analysis of DNA methylation with lifetime cannabis use
43Zhouqing FangGraph Neural Network for Genetic Discovery from Genome Wide Association Studies
44Poster Presenter Unavailable
45Michael GarvinThe Missing Heritability of Complex Disorders: Structural Variants Hiding in Plain Site
46Eric BravermanThe consequences of the sins of thy parents: multi-generational neurogenetic and epigenetic impacts on reward dysregulation and cognitive impairments require cost-effective standard Brain Health Check (BHC)
47Hongsheng GuiDemographics and genetic epidemiology of opioid use disorder in national-wide population-based biobanking cohorts
48Kyung-An HanSocial context impacts inhibitory control
49Jeffrey HatfieldGenetic Variation in Cocaine Preference in the Drosophila melanogaster Genetic Reference Panel.
50Elaine Hebda-BauerTranscriptional Profiling of the Hippocampus in an F2 Cross of a Genetic Rat Model of Internalizing vs. Externalizing Behavior and Addiction Liability
May 4th - Poster Session C ( 3 pm to 4:15 pm)
Poster #Name and EmailAbstract
51Robert HitzemannOn the Alignment of Gene Expression with Delay Discounting (DD) in Heterogeneous Stock (HS) Rats
52Will LynchOxycodone behaviors in Cacna1h knockout mice
53Xiaoyu LiangA Mediating Role for Epigenetic Aging in the Relationship Between People Who Inject Drugs with HCV and All-Cause Mortality
54Luis Castro-de-AraujoBidirectional causal modeling with instrumental variables and data from relatives
55Brittany KuhnNetwork-based clustering approach models multi-symptomatic opioid use disorder vulnerability
56Ming-Fen HoSingle cell transcriptomics reveals distinct transcriptional response to oxycodone and buprenorphine by iPSC-derived brain organoids from patients with opioid use disorder
57Emma JohnsonAssociations between polygenic liability for schizophrenia and cannabis-induced experiences
58Jermaine JonesHeroin Use Severity is not Associated with Telomere Length in Individuals with Opioid Use Disorder of African Ancestry
59Radka KanevaGenetic Correlates of Impulsivity in Bulgarian Substance Users
60Fatah KashanchiCannabinoids reduce extracellular vesicle release from HIV-1 infected myeloid cells and inhibit viral transcription
61Marcus KaulMultiple long-term changes of neurotransmission-related gene expression correlate with behavioral impairment caused by methamphetamine and NeuroHIV
62Panjun KimDe novo genome assembly for HXB/BXH recombinant inbred strains using Hi-C data
63Drew KiralyThe gut microbiome as a critical regulator of fentanyl seeking an proteomic regulation in the nucleus accumbens
64Deniz KoyuncuMissing Value Knockoffs for Genome-Wide Association Studies
65Dongbing LaiPolygenic risk scores analysis of alcohol use disorder
66Hwuyoung LeeModeling Multivariate Age-related Brain Imaging Variables with Dependence: an application to assess the smoking effects on white matter tracts during brain aging
67Paige LemenSocial Isolation in Adolescence Leads to an Increased Resilience to the Risk of Opioid Abuse in Adulthood in Rats
68Gabriel OdomDetecting Regions of Concurrent and Differential Methylation with coMethDMR
69Shuangying LengOral oxycodone self-administration induces long-lasting increases in body temperature in rats
70Rudong LiInvestigating genetic inheritability of RNA alternative splicing in alcohol use disorders
71Mingkuan LinGene expression regulation for persons with HIV who inject drugs
72Sanxiong LiuThe interplay between AUTS2-/FBRSL1-ncPRC1.3 in transcriptional regulation and brain development
73Shirelle LiuRelating individual differences in vulnerability to morphine self-administration in rats to gene expression in the medial prefrontal cortex (mPFC)
74Falk LohoffEpigenome-wide association study of alcohol consumption in N=8161 individuals and relevance to alcohol use disorder pathophysiology
75Qing LuFunctional Neural Networks for High-dimensional Genetic Data Analysis
May 4th - Poster Session D ( 4:15 pm to 5:30 pm)
Poster #Name and EmailAbstract
76Robert HitzemannIdentification of modifiers of MA intake in the presence of the high risk Taar1m1J/m1J genotype
77Jose Martinez-MaganaThe prefrontal cortex transcriptomic landscape of the interaction between post-traumatic stress disorder and opioid misuse
78Benpeng MiaoMethamphetamine induced regional-specific transcriptomic and epigenetic changes in rat brain
79Adaku OfoegbuThe Role of Phase II Metabolic Enzymes and Drug Transporters on Buprenorphine Pharmacogenomics in Opioid Use Disorder Management
80Evaristus NwuliaComparative Response to Alcohol in Individuals with ADH1B*1 and ADH1B*3 Polymorphisms
81Andreas PfenningWhat can bats, capybaras, and tree shrews tell us about the genetic basis of addiction?
82Abraham PalmerComparing polygenic signals across species
83Rohan PalmerMolecular Brain Signatures Of Chronic Alcohol Use Across Species
84BaDoi PhanSingle cell multi-omics of the rhesus macaque striatum reveal regulatory mechanisms underlying the genetic basis of addiction
85Michael MilesBehavioral And Expression Genetics Identification Of Genes Modulating Progressive Ethanol Consumption In Diversity Outbred Mice
86Chen MoThe causal effect of tobacco smoking on white matter brain aging by Mendelian randomization analysis on UK Biobank participants
87Sage MorisonIdentification and manipulation of dopamine neurons recruited by fentanyl self-administration
88Joe NadeauPhenotypic plasticity, the missing dimension of phenotypic variation and disease risk
89Nghi NguyenCrisis in the NICU and the Medley with Midazolam
90Jaclyn NoshayHeroin abuse-associated transcriptional and epigenetic alterations in the orbitofrontal cortex concentrate in GABA interneurons and provide insight into potential sex-specific regulatory response
91Yaira NunezResearching longitudinal changes in polysubstance use and abuse: Recontacting participants during COVID-19 pandemic
92Steve OghumuSex differences in susceptibility to addiction: Role for X chromosome inactivation?
93Ashley OlsonDiscovery of gene co-expression networks associated with cocaine-related behaviors in Collaborative Cross mice
94Jimmy OlusakinTranscriptomic adaptations in emotional and sensory brain nuclei in perinatal fentanyl exposed rodents
95Tony PanSingle-cell analysis reveals shared and distinct immune response and metabolism between SARS-CoV-2 and HIV-1 infections
96Gary PeltzOndansetron Reduces Neonatal Opioid Withdrawal Severity: A Randomized Clinical Trial
97Roseann PetersonInvestigating causal influences on alcohol consumption and major depression across middle and late adulthood – A genetically informative pseudo-longitudinal approach
98Robert PhilibertThe Dual Utility of Cg05575921 Methylation in Lung Cancer Screening Decision Making: The Value of Racial and Gender Bias Free Precision Epigenetics Approaches in Guiding Low Dose Computerized Tomography (LDCT) Use and Smoking Cessation.
99Mudit TyagiCocaine sensitizes the CD4+ T-cells for HIV infection by co-stimulating NF-kb, NFAT, and AP-1
100Amara Plaza-JenningsAltered microglial genome structure and transcription in HIVE impact HIV integration
May 11th - Poster Session E ( 2:30 pm to 3:45 pm)
Poster #Name and EmailAbstract
101Lakmini PremadasaLong-term delta-9-tetrahydrocannabinol administration promotes lncRNA MMP25-AS1-MMP25 mRNA interactions to preserve intestinal epithelial barrier function in chronic HIV/SIV infection
102Bryan QuachTranscriptome-wide association analyses identify genes associated with HIV latent reservoir and cocaine abuse
103Alexia RamseyEmerging evidence of behavior change associated with fully-remote delivery of a genetically-informed smoking cessation intervention
104Nathaniel RobinsonTranscription factor 4 coordinates gene expression and dopamine responses in the nucleus accumbens
105Kyle SullivanMulti-omic network analysis identifies key neurobiological pathways in opioid addiction
106Laura SabaQuantitative multi-organ transcriptome in the Hybrid Rat Diversity Panel: A resource for systems genetics studies of substance use disorders
107Sandra Sanchez-RoigeGenome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry
108Michael SaulCommon genetic and genomic underpinnings of learned and unlearned addiction-related behaviors
109Katherine SavellMolecular characterization of cocaine-seeking engram neurons in the infralimbic cortex using single nuclei RNA-sequencing in rats
110Souvik SealRapid Condition adaptive Fused Graphical Lasso
111Laurel SeemillerStrain-dependent contextual fear learning outcomes after acute adolescent ethanol exposure: Examining the role of the dorsal hippocampal transcriptome
112Anna MoszczynskaMethamphetamine Neurotoxicity Does Not Contribute to Methamphetamine Use Disorder in Parkin Knockout Rats
113Michael SheldonThe NIDA, ABCD, COGA and NESARC Biobanks: Sampled Provides a Critical Resource for Research into the Genetics and Epigenetics of Substance Abuse in Humans
114Zhouyue ShiThe role of m6A RNA methylation in maintaining cell type specific functions in the basal ganglia
115Madhurbain SinghCross-Lagged Mendelian Randomization: Integrating Genomic Data with Repeated-Measures Designs to Strengthen Causal Inference
116Srah Swinford-JacksonEpigenetic mechanisms underlying susceptibility to methamphetamine self-administration in methamphetamine-sired male rats
117Yalun TanNeuron Navigator 1 (Nav1) Regulates Learning, Memory and the Response to Multiple Drugs of Abuse (DOA)
118Stephanie CaligiuriBrain-body chemosensing regulates the addictive properties of nicotine
119Francesca TeleseSingle-cell transcriptomics reveals that reduced glucose metabolism is linked to addiction-like behavior in rats
120Samikkannu ThangavelHIV-1 Tat and Cocaine Impact the LIN01133-hsa-miR-4726-5p - NDUFA9 axis to Modulate Astrocyte Energy Metabolism  
121Iris TitosMolecular pathways regulating sleep and SUD
122Dong-Binh TranClosing the loop on Turicibacter
May 11th - Poster Session F ( 3:45 pm to 5 pm
Poster #Name and EmailAbstract
123Xingyan WangTrans-Ancestry Fine-Mapping and Ancestry Heterogeneity Analysis for Smoking & Drinking Addiction Phenotypes using 3.4 Million Individuals with Diverse Ancestries
124Hang ZhouAdvanced genetic study of problematic alcohol use in > 1 million subjects from multiple populations
125Zhuzhu ZhangSingle-cell characterization of epigenomic remodeling in cocaine self-administration in mice
126Jessica ZhouComputational analysis of snATAC-seq from amygdalae reveals cell type-specific chromatin regions associated with cocaine addiction
127Makeda TurnerEpigenome editing of nucleus accumbens cell subtype transcripts regulated by fentanyl abstinence
128Avanish VeerappaA multipronged approach unravels the spectrum of variants and transcriptomic signatures in distinct stages of substance use and addiction
129Paige LemenMorphine and Naloxone Responses are controlled by Oprm1 and Fgf12 loci in the murine BXD family: Epistasis and time-dependent locomotor interaction effects
130Qun WangTargeting Delivery of Therapeutic Vaccines to Treat HIV People Who Use Drugs
131Robert WilliamsA Multiomic Genetic Resource for Analysis of Gene Function and SUD in the Rat CNS
132Christina WooIntracellular protein targets of the opioids
133Lisa WuMimicking concurrent viral infection and substance abuse in a cell culture model
134Kuranosuke YamadaMapping and Analyses of Differential Co-expression Networks of Striatum Tissue in Cocaine-treated, high-diversity mouse populations
135Fengchun YeRole of nuclear receptors in epigenetic silencing of HIV in microglia and neuroprotection following methamphetamine exposure
136Zhenyao YeMeta-analysis of transcriptome-wide association studies across 13 brain tissues identified novel clusters of genes associated with nicotine addiction
137Pengyue ZhangNetwork medicine and electronic health record-based discovery of repurposable drugs for neonatal opioid withdrawal syndrome (NOWS)
138Shuping ZhongDeficiency in key transcription factor Brf1 of RNA Pol III genes results in protein synthesis obstacle and phenotypic alteration
139Nathan GaddisAssociation of Polygenic Risk Scores with the Need for Pharmacologic Treatment of Neonatal Abstinence Syndrome: Results from a Genome Wide Association Study
140Rhea SullivanmiRNAs that regulate neurodevelopment also respond to opioid withdrawal in neonatal opioid withdrawal syndrome (NOWS) infant saliva
141Peter BarrPredicting Substance Use Disorders: A Multifactorial Risk Index Combining Clinical, Environmental, and Genetic Risk Factors
Abstracts and Agenda from March 2021 meeting
Name and EmailAbstractPoster SessionTalk SessionSlack link
Kerry J. ResslerFrom SNPs and Stress to SUDs: Genetics and Epigenetic mediators of Social Determinants of Health, PTSD, and Substance Use DisordersWednesday   
2:00 to 3:00
Monday   
11:00 AM
Kerry-ressler
Christopher GuevaraParkinson’s disease gene mutation perturbs behavioral and synaptic adaptions to social defeat stressMonday   
4:00 to 5:00
Monday   
11:15 AM
Guevara
Jean Lud CadetIncreased cannabinoid receptor expression in the hippocampus drives abstinence from compulsive methamphetamine takingMonday   
2:00 to 3:00
Monday   
11:30 AM
Cadet-Jean-Lud
Shareefa DalvieGenomic influences on self-reported childhood maltreatmentMonday   
3:00 to 4:00
Monday   
11:45 AM
Dalvie
Randall J. EllisGenomic prediction of alcohol and opioid use disorders using machine learningMonday   
4:00 to 5:00
Monday   
1:00 PM
Ellis
Seon-Kyeong JangRare variant heritability of tobacco use: Evidence from deep whole-genome sequencing of up to 26,000 individualsTuesday   
2:00 to 3:00
Monday   
1:20 PM
Jang
Daniel JacobsonEmbracing Complexity: Supercomputing Enabled Systems Biology to Understand Complex NeurosystemsTuesday   
2:00 to 3:00
Monday   
1:40 PM
Jacobson
Rohan PalmerComputational Drug Discovery for Cocaine and Opioid Use DisordersWednesday   
2:00 to 3:00
Tuesday   
11:00 AM
Palmer
Brock GrillGenetic behavioral screen identifies an orphan anti-opioid systemMonday   
4:00 to 5:00
Tuesday   
11:15 AM
brock-grill
Vivek KumarDiscovery of novel, addiction-relevant genes through endophenotype modelling of Knockout Mouse Project (KOMP) dataTuesday   
3:00 to 4:00
Tuesday   
11:30 AM
Kumar
Michelle L. HastingsAntisense Oligonucleotide Approaches to the Treatment of DiseaseMonday   
4:00 to 5:00
Tuesday   
11:45 AM
Michelle-hastings
Christiann GainesAssessing the impact of compositionally distinct gut microbiotas on differences in initial cocaine sensitivity in closely related inbred mouse substrainsMonday   
4:00 to 5:00
Tuesday   
1:00 PM
Gaines
Sierra SimpsonDrugs, Bugs, and SUDs: Leveraging the Microbiome and Metabolome to Predict Addiction LiabilityWednesday   
3:00 to 4:00
Tuesday   
1:20 PM
Simpson
Drew KiralyManipulations of gut microbiome diversity alter cocaine seeking behavior and striatal gene expressionTuesday   
2:00 to 3:00
Tuesday   
1:40 PM
kiraly-d
Alexander UrbanTechnically challenging types of genome sequence variants with relevance to brain function, and new approaches to their analysisWednesday   
3:00 to 4:00
Wednesday   
11:00 AM
Urban
Melissa GymrekThe impact of short tandem repeats on complex traitsMonday   
4:00 to 5:00
Wednesday   
11:15 AM
Gymrek
Avindra NathEpigenetic regulation of retroviruses in embryogenesis, oncogenesis and neurodegenerationTuesday   
4:00 to 5:00
Wednesday   
11:30 AM
Nath
Sandhya ChandrasekaranNeuron-specific regulation of chromosomal megadomains in the mammalian brain implicated in endogenous retroviral silencingMonday   
3:00 to 4:00
Wednesday   
11:45 AM
Chandrasekaran
Jimmy OlusakinTranscriptomic adaptations in emotional and sensory brain nuclei in perinatal fentanyl exposed rodentsTuesday   
4:00 to 5:00
Wednesday   
4:00 PM
Olusakin
Marta PratelliDrugs of abuse drive activity producing changes in gene expression that switch neurotransmitters and behaviorsWednesday   
2:00 to 3:00
Wednesday   
4:20 PM
Pratelli
Jian FengNeuron-specific role of methylated DNA cytosine dioxygenase TET1 in cocaine addictionMonday   
4:00 to 5:00
Wednesday   
4:40 PM
Feng
Arpana AgrawalAn Update from the Psychiatric Genomics Consortium’s Substance Use Disorder Working Group (PGC-SUD)Monday   
2:00 to 3:00
 Agrawal
Carter AllenA statistical framework for network-based discovery of opioid use sub-populations in rats using the Bayesian stochastic block modelMonday   
2:00 to 3:00
 Allen
Robert AnholtThe Drosophila Brain on Cocaine at Single Cell ResolutionMonday   
2:00 to 3:00
 Anholt
Brad AouizeratFrequent Cocaine Use is Associated with Larger HIV Reservoir Size Quantified by the Intact Proviral DNA AssayMonday   
2:00 to 3:00
 Aouizerat
Jared BagleyImpulsivity Phenotypes are Linked with Novel Genetic Loci in Diversity Outbred MiceMonday   
2:00 to 3:00
 Bagley
Brandon BakerDissecting the Genetic Basis of Variation in Cocaine and Methamphetamine Consumption in Outbred Populations of Drosophila melanogasterMonday   
2:00 to 3:00
 Baker
Amanda Barkley-LevensonValidating novel human GWAS hits for problematic alcohol use and consumption using genetic mouse modelsMonday   
2:00 to 3:00
 Barkley-Levenson
Peter BarrIdentifying Shared and Specific Genetic Risks for Substance Use DisordersMonday   
2:00 to 3:00
 Barr
Amelie BaudInvestigating the gut-brain axis in 4,006 P50 Heterogeneous Stock ratsMonday   
2:00 to 3:00
 Baud
Yudhishtar BediPaternal Alcohol Exposure Leads To Altered Sperm Epigenome And Fetal Growth RestrictionMonday   
2:00 to 3:00
 Bedi
Jacob BeierleBALB/c substrain differences in whole brain concentrations of the highly potent oxycodone metabolite, oxymorphone map to chromosomes 5, 10, and 16 in a reduced complexity crossMonday   
2:00 to 3:00
 Beierle
Andrew BergenMultiethnic Prediction of Nicotine Biomarkers and Associations with Nicotine DependenceMonday   
2:00 to 3:00
 Bergen
Laura BierutWhen will we be ready to bring polygenic risk scores into clinical medicine?Monday   
2:00 to 3:00
 Bierut
Molly BogueMouse Phenome Database: Resources and analysis tools for curated and integrated primary mouse addiction related phenotype dataMonday   
2:00 to 3:00
 Bogue
Heather BranscomeRetroviral Infection of Human Neurospheres and Use of Stem Cell EVs to Repair Cellular DamageMonday   
2:00 to 3:00
 Branscome
Caleb BrowneHeroin self-administration and seeking induces transcriptional reprogramming throughout the brain’s reward circuitryMonday   
2:00 to 3:00
 Browne
Jason BubierGenetic variation in opioid-induced respiratory depressionMonday   
2:00 to 3:00
 Bubier
James CaiMachine Learning Analysis of Single-cell Gene Regulatory Networks Reveals Signature Transcriptional Responses in Neurons to Acute Morphine TreatmentMonday   
2:00 to 3:00
 Cai
Cali CalarcoMitochondria-Related Nuclear Gene Expression in Reward Related Brain Regions and Blood Mitochondrial Copy Number after Developmental Fentanyl Exposure in Adolescent Male and Female C57BL/6 MiceMonday   
2:00 to 3:00
 Calarco
Rianne CampbellMolecular Profiling of Mouse Ventral Pallidum Projection NeuronsMonday   
3:00 to 4:00
 Campbell
Nazzareno CannellaLong access heroin self-administration induces grey matter volume reduction in NIH Heterogeneous Stock ratsMonday   
3:00 to 4:00
 Cannella
Anjelica CardenasThe Functional Role of a Human Polymorphism (rs2304297) in the 3’-UTR of the CHRNA6 Gene in Nicotine-Induced Locomotion and Anxiety in Adolescent Sprague Dawley RatsMonday   
3:00 to 4:00
 Cardenas
Diana CarrenoNicotine plus cue-induced reinstatement is enhanced in adolescent Sprague-Dawley rats containing the Human 3’UTR polymorphism (rs2304297) in the alpha(_)6 nicotinic acetylcholine receptor subunitMonday   
3:00 to 4:00
 Carreno
Lieselot CarretteIdentification of genetic variants that contribute to compulsive cocaine intake in ratsMonday   
3:00 to 4:00
 Carrette
Andy ChenMassively Parallel Reporter Assay Reveals Functional Impact of 3’-UTR SNPs Associated with Neurological DisordersMonday   
3:00 to 4:00
 Chen
Fang ChenTrans-ethnic Transcriptome-wide Association Study for Smoking Addiction in 1.3 Million Individuals Yields Insights into Tobacco Use Biology and Drug RepurposingMonday   
3:00 to 4:00
 Chen-f
Li-Shiun ChenPredicting smoking cessation treatment outcomes with genetic risk scores and biomarkersMonday   
3:00 to 4:00
 Chen-LiShiun
Shuo ChenGenetic Fine-mapping with Dense Linkage Disequilibrium Blocks: genetics of nicotine dependenceMonday   
3:00 to 4:00
 Chen-s
Apurva ChitreExponential increase in QTL detection with increased sample size in heterogeneous stock ratsMonday   
3:00 to 4:00
 Chitre
Olivia CorradinHypoacetylated neuronal enhancers in opioid overdoses converge on the regulatory circuit of specific genesMonday   
3:00 to 4:00
 Corradin
Caitlin CrookThe interplay between cocaine and the feeding hormone leptin in genetically diverse ratsMonday   
3:00 to 4:00
 Crook
Renata CupertinoNeural correlates of polygenic risk for cannabis use and cannabis use disorderMonday   
3:00 to 4:00
 Cupertino
M. Imad DamajGenetic Variation in nicotine withdrawal in MiceMonday   
3:00 to 4:00
 Damaj
Udita DattaNaturally occurring variation in cocaine self-administration among high-diversity mouse populationsMonday   
3:00 to 4:00
 Datta
Jeremy J. DayThe extracellular matrix protein Reelin is enriched in cocaine-activated D1-MSNs and modulates transcriptional responses to dopamineMonday   
3:00 to 4:00
 Day
Giordano de GuglielmoCharacterizaiton of individual differences in “addiction score” and choice between cocaine versus palatable food choice in Heterogeneous Stock (HS) male and female ratsMonday   
3:00 to 4:00
 de Guglielmo
Catherine DeMarinoEffects of Marijuana on Viral Transcription in HIV-1 Infected Cells and Resulting Extracellular Vesicle ReleaseMonday   
3:00 to 4:00
 DeMarino
Marissa EhringerDifferential gene expression responses to oxycodone self-administration in the amygdala and prefrontal cortex of inbred rat strainsMonday   
3:00 to 4:00
 Ehringer
Kit K. ElamFunctional Polygenic Risk for Aggression Indirectly Predicts Adult Substance Use Disorder Diagnoses via Substance Use Offending in Emerging AdulthoodMonday   
4:00 to 5:00
 Elam
Luke EvansGenetic architecture of four smoking behaviors using partitioned SNP heritabilityMonday   
4:00 to 5:00
 Evans
Delaney FischerNovel Approach for Cell-Type Specific Profiling of Histone Post-Translational Modifications and Corresponding Gene ExpressionMonday   
4:00 to 5:00
 Fischer
Megan FoxFentanyl abstinence causes neuron subtype specific structural and molecular changes in the nucleus accumbensMonday   
4:00 to 5:00
 Fox
Hongyu GaoSingle cell analyses of putamen region from subjects with alcohol use disordersMonday   
4:00 to 5:00
 Gao
Jonathan GewirtzDaily morphine exposure activates synaptogenesis and other neuroplasticity-related gene networks in the dorsomedial prefrontal cortex of male and female ratsMonday   
4:00 to 5:00
 Gewirtz
Michael GoldingEpigenetic Toxicity: Preconception Paternal Exposures and the Programming of Offspring Birth DefectsMonday   
4:00 to 5:00
 Golding
German GornalusseChronic heroin use generates distinct cleavage patterns of tRNA-Gly-GCC in semenMonday   
4:00 to 5:00
 Gornalusse
Rahul GudaIntegrated systems analysis of mixed neuroglial cultures proteome post oxycodone exposure: Implications for altered synaptogenesisMonday   
4:00 to 5:00
 Guda
Mustafa Hakan GunturkunRatsPub: a webservice aided by deep learning to mine PubMed for addiction-related genesMonday   
4:00 to 5:00
 Gunturkun
Megan Hastings HagenauerGenetic liability for internalizing versus externalizing behavior manifests in the adult hippocampus: A comparison of the results of transcriptional profiling studies performed in eight bred rat modelsMonday   
4:00 to 5:00
 Hagenauer
Peter HamiltonCREB-mediated activation of Zfp189 and re-engineering ZFP189 within mouse accumbens reveal transcriptional mechanisms governing cocaine-induced neuroadaptationsMonday   
4:00 to 5:00
 Hamilton
Alexander HatoumGenome-wide Association Study of multiple substance use disorders identifies novel loci related to mental and physical healthMonday   
4:00 to 5:00
 Hatoum
Jordan HernandezDouble Trouble: Adolescent alcohol exposure in pre and postnatal oxycodone offspringMonday   
4:00 to 5:00
 Hernandez
Alannah HillmerThe genetic contribution of cannabis use in opioid addiction: An investigation into sex differencesTuesday   
2:00 to 3:00
 Hillmer
Robert HitzemannTranscriptional Features Associated with Delay Discounting in HS RatsTuesday   
2:00 to 3:00
 Hitzemann
An HoangEpigenomic and machine learning strategies reveal key pathways that distinguish the opioid dependent brainTuesday   
2:00 to 3:00
 Hoang
Saeedeh HosseinianA forward genetic screen of ENU-mutagenised zebrafish identifies lines showing deficits in impulse controlTuesday   
2:00 to 3:00
 Hosseinian
Spencer HuggettGenes Identified in Rodent Studies of Alcohol and Nicotine Intake Are Enriched in GWASs of Human Substance UseTuesday   
2:00 to 3:00
 Huggett
Changhoon JeeCross-species functional validation of overlapping GWAS candidates between tobacco smoking in human and socially acquired nicotine IVSA in ratsTuesday   
2:00 to 3:00
 Jee-1
Changhoon JeeNeuropeptidergic regulation of Compulsive Seeking behavior in C. elegansTuesday   
2:00 to 3:00
 Jee-2
Cheng JiIdentification of hepatic off-targets of anti-HIV protease inhibitors involved in organelle stress response and liver injuryTuesday   
2:00 to 3:00
 Ji
Emma JohnsonThe relationships between cannabis, tobacco, and schizophrenia: a genetically informed perspectiveTuesday   
2:00 to 3:00
 Johnson
Eric Otto JohnsonGenomic SEM GWAS of Opioid Addiction: Digging into OPRM1 and BeyondTuesday   
2:00 to 3:00
 Johnson
G Allan JohnsonHeritability of imaging phenotypes from combined magnetic resonance and light sheet microscopyTuesday   
2:00 to 3:00
 Johnson
Yan JouroukhinRole of astrocyte mitochondria in opioid withdrawalTuesday   
2:00 to 3:00
 Jouroukhin-1
Yan JouroukhinRole of astrocyte mu opioid receptors in morphine withdrawalTuesday   
2:00 to 3:00
 Jouroukhin-2
Marsida KallupiCharacterization of addiction-like behaviors to oxycodone in Heterogenous Stock ratsTuesday   
2:00 to 3:00
 Kallupi
Marcus KaulChronic, low dose methamphetamine reveals sexual dimorphism in memory performance impaired by exposure to HIV-1 Tat proteinTuesday   
2:00 to 3:00
 Kaul
Paul KennyHedgehog-interacting protein in habenula regulates nicotine intakeTuesday   
2:00 to 3:00
 Kenny
Alena KozlovaSex and brain region-specific gene expression and imprinting of nicotine sensitization and self-administration in rats inform GWAS findings of human smoking phenotypesTuesday   
2:00 to 3:00
 Kozlova
Brittany KuhnSensation seaking behavior contributes to opioid dependence vulnerability in a sex-dependent mannerTuesday   
3:00 to 4:00
 Kuhn
Donald KuhnLong access heroin self-administration significantly alters gut microbiome diversity, structure and compositionTuesday   
3:00 to 4:00
 Kuhn-d
Adele LeggieriAnkk1 regulates the dopaminergic response mediated by dopamine receptor D2 in zebrafish brainTuesday   
3:00 to 4:00
 Leggieri
Paige LemenMolecular and Phenotypic Causes and Networks Linked to Morphine and Naloxone Responses in the BXD Family: Time-Dependent Locomotor EffectsTuesday   
3:00 to 4:00
 Lemen
Mark Anthony Leon-DuqueNew chemical tools to elucidate the interactomics and the epigenetics of opioid drugsTuesday   
3:00 to 4:00
 Leon-Duque
Emily LevittPhenotypic structure of delay discounting in relation to diverse health behaviours in a general community sample of 10,701 adultsTuesday   
3:00 to 4:00
 Levitt
Boyang LiIncorporating local ancestry into methylation quantitative trait loci (meQTL) mapping for tobacco smoking in the African American populationTuesday   
3:00 to 4:00
 Li-B
Michael LiA social genomics perspective on methamphetamine use, HIV, and intimate partner violenceTuesday   
3:00 to 4:00
 Li-m
Zhicheng LinGenetic basis for substance use exacerbation of COVID-19Tuesday   
3:00 to 4:00
 Lin
Jyoti LodhaEffects of Social Isolation and Ethanol Drinking on the PFC TranscriptomeTuesday   
3:00 to 4:00
 Lodha
Ryan LoganTranscriptional alterations in opioid use disorder reveal the interplay between neuroinflammation and synaptic remodeling across corticostriatal circuitsTuesday   
3:00 to 4:00
 Logan
Falk LohoffPrescription opioid use and risk for major depressive disorder: a multivariable Mendelian randomization analysisTuesday   
3:00 to 4:00
 lohoff
Ryan LuskThe alternative splicing and alternative polyadenylation transcriptional landscape of the HXB/BXH recombinant inbred rat panel and its role in predisposition to voluntary alcohol consumptionTuesday   
3:00 to 4:00
 Lusk
Tianzhou MaWhite matter integrity and nicotine dependence in smokers: evaluating vertical and horizontal pleiotropyTuesday   
3:00 to 4:00
 Ma
Trudy MackayThe Drosophila Brain on Cocaine at Single Cell ResolutionTuesday   
3:00 to 4:00
 Mackay
Katarzyna MacurComprehensive response of HIV-infected human primary macrophages to methamphetamine exposureTuesday   
3:00 to 4:00
 Macur
Brion MaherAn Examination of Differential Methylation and Gene Expression in Dorsolateral Prefrontal Cortex Following Opioid OverdoseTuesday   
3:00 to 4:00
 Maher
Maria Cecilia Garibaldi MarcondesDetection of H3K4me3 identifies neuroHIV signatures and detects genomic effects of Methamphetamine in addiction pathways in post-mortem HIV+ brain specimens that are not eligible to transcriptome analysisTuesday   
3:00 to 4:00
 Marcondes
Lisa MaturinThe Cocaine and Oxycodone Biobanks: Two repositories of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of cocaine or oxycodone self-administrationTuesday   
3:00 to 4:00
 Maturin
Stephen McGeeFrom the developers of Smokescreen: a booster panel for development of addiction polygenic risk scoresTuesday   
3:00 to 4:00
 McGee
Skyler McShanePositive Relationship between Set-Shifting, Learning Rate and Delay DiscountingTuesday   
4:00 to 5:00
 McShane
Aleksandra MechIdentification of lines showing altered sensitivity to rewarding effects of nicotine using a self-administration assay in zebrafishTuesday   
4:00 to 5:00
 Mech
Emily MendezAngiogenic Gene Networks are Dysregulated in Postmortem Brain of Opioid Use Disorder Subjects: Evidence from Multi-Omics and Imaging ApproachesTuesday   
4:00 to 5:00
 Mendez
Munise MerterogluGene regulatory responses to developmental drug exposures in zebrafishTuesday   
4:00 to 5:00
 Merteroglu
Philipp MewsEpigenetic Priming Drives Aberrant Gene Expression Linked to Cocaine RelapseTuesday   
4:00 to 5:00
 Mews
Arojit MitraDiscovery of novel, addiction-relevant genes through endophenotype modelling of Knockout Mouse Project (KOMP) dataTuesday   
4:00 to 5:00
 Mitra
Swarup MitraHistone demethylase JMJD3 mediates opioid-induced cellular and behavioral plasticityTuesday   
4:00 to 5:00
 Mitra
Mahesh MohanCannabinoid modulation of the microbiota-gut-brain axis in HIV/SIV infectionTuesday   
4:00 to 5:00
 Mohan
Janitza L. Montalvo-OrtizNeuronal Methylome and Hydroxymethylome Profiling of Opioid Use DisorderTuesday   
4:00 to 5:00
 Montalvo-Ortiz
Alyssa MooreEvaluating the stability of measures of motivation and preference in a behavioral economic drug self-administration procedureTuesday   
4:00 to 5:00
 Moore
Milad MortazaviPolymorphic SNPs, short tandem repeats and structural variants cause differential gene expression among inbred C57BL/6 and C57BL/10 substrainsTuesday   
4:00 to 5:00
 Mortazavi
Anna MoszczynskaThe Role of PARKIN in Methamphetamine Use DisorderTuesday   
4:00 to 5:00
 Moszczynska
Megan MulliganRat reduced complexity model of oxycodone self-administration and stress responsivenessTuesday   
4:00 to 5:00
 Mulligan
Daniel MunroMapping genotype-expression associations in Heterogeneous Stock rat brains to advance behavioral genetics researchTuesday   
4:00 to 5:00
 Munro
Elliot C. NelsonRetrospective reports of itching with initial opioid misuse are strongly associated with risk of opioid use disorder (OUD), specific OUD symptoms, and more problematic courseTuesday   
4:00 to 5:00
 Nelson
Jie NiPeerPub: a novel device for concurrent oral operant conditioning by two ratsTuesday   
4:00 to 5:00
 Ni
Maria NiarchouIdentifying the medical phenome of patients with a prescription of buprenorphine in the Electronic Health Record (EHR) and the role of genetic riskTuesday   
4:00 to 5:00
 Niarchou
Steve OghumuX chromosome inactivation in sex disparities to substance use disorderTuesday   
4:00 to 5:00
 Oghumu
Angela OzburnNicotine, midazolam, morphine, and methamphetamine intake in High Drinking in the Dark miceTuesday   
4:00 to 5:00
 Ozburn
Gita PathakDissecting polysubstance use disorders via polygenic risk scoringWednesday   
1:00 to 2:00
 Pathak
Jack PatteeModeling recommendations and simulated power for the analysis of expression quantitative trait loci in the Hybrid Rat Diversity PanelWednesday   
1:00 to 2:00
 Pattee
McKenzie PavlichCharacterization of addiction-like behaviors to alcohol in Heterogenous Stock ratsWednesday   
1:00 to 2:00
 Pavlich
Robert PhillipsAn atlas of transcriptionally distinct cell populations within the rat ventral tegmental areaWednesday   
1:00 to 2:00
 Phillips
Tamara J. Phillips-RichardsBidirectional Effects of a Taar1 SNP Conversion on Methamphetamine TraitsWednesday   
​​​​​​​1:00 to 2:00
 Phillips-Richards
Amara Plaza-JenningsCell-type specific genomics and transcriptomics of HIV in the brainWednesday   
​​​​​​​1:00 to 2:00
 Plaza-Jennings
Oksana PolesskayaHigh-throughput genotyping of HS rats using low-coverage sequencingWednesday   
​​​​​​​1:00 to 2:00
 Polesskaya
Samuel PowellTranscription Factor-Driven Production of Midbrain Dopaminergic Neurons from Human iPS Cells and Psychiatric Disease Risk ModelingWednesday   
​​​​​​​1:00 to 2:00
 Powell
Alex RamseyAdvancing the development of a genetically-informed behavioral intervention to promote tobacco treatment and cessationWednesday   
​​​​​​​1:00 to 2:00
 Ramsey
Benjamin ReinerTranscriptomic characterization of the nucleus accumbens in an animal model of opioid use disorder using single-nuclei RNA sequencingWednesday   
​​​​​​​1:00 to 2:00
 Reiner
Jose Maria RestrepoExpression-based polygenic score derived from corticolimbic DCC gene co-expression networks as a biomarker of SUD riskWednesday   
​​​​​​​1:00 to 2:00
 Restrepo
Pamela Romero VillelaA gene-by-gene interaction analysis of rs16969968 and genome-wide loci on cigarettes per day in the UK BiobankWednesday   
​​​​​​​1:00 to 2:00
 Romero Villela
Adrian RothenfluhIterative ATAC-seq to home in on specific neuron subsetsWednesday   
​​​​​​​1:00 to 2:00
 Rothenfluh
Laura SabaWebinar Series on Quantitative Genetics Tools for Mapping Trait Variation to Mechanisms, Therapeutics, and InterventionsWednesday   
​​​​​​​1:00 to 2:00
 Saba
Sandra Sanchez-RoigeGenome-wide association study of ‘not as prescribed’ prescription opioid use in 132,113 23andMe research participantsWednesday   
​​​​​​​1:00 to 2:00
 Sanchez-Roige
Michael SaulThe 5-HT1D receptor modulates volitional cocaine-related behaviorsWednesday   
​​​​​​​1:00 to 2:00
 Saul
Gretchen SaundersTrans-ancestry GWAS meta-analysis of tobacco and alcohol useWednesday   
​​​​​​​1:00 to 2:00
 Saunders
Lori SchirleA Novel Data-Driven Approach to Evaluate the Spectrum of Opioid Use in Electronic Health DataWednesday   
2:00 to 3:00
 Schirle
Laurel SeemillerFear learning deficits after acute ethanol or MK-801 treatment in adolescent and adult C57BL/6J and DBA/2J inbred miceWednesday   
​​​​​​​2:00 to 3:00
 Seemiller
Nancy SeyElucidating neurobiological processes underlying cigarette smoking and alcohol use traitsWednesday   
​​​​​​​2:00 to 3:00
 Sey
Alexander SmithDorsal Peduncular Prefrontal Cortex contains cells uniquely sensitive to opioids: Relevance to opioid reward and addictionWednesday   
​​​​​​​2:00 to 3:00
 Smith
Jerry StitzelThe Use of Chromosome Substitution Strains to Identify Genetic Modifiers that Alter the Impact of Chrna5 Deletion on Oral Nicotine Intake in MiceWednesday   
​​​​​​​2:00 to 3:00
 Stitzel
Jing SunEpigenetic age acceleration among person who inject drugs with poorly controlled HIVWednesday   
​​​​​​​2:00 to 3:00
 Sun
Boris TabakoffAre We Going in Circles: Circular RNA as Another Integral Member of the RNA World?Wednesday   
​​​​​​​2:00 to 3:00
 Tabakoff
Yalun TanNeuron Navigator 1 (Nav1) Regulates Learning, Memory and the Response to Multiple Drugs of Abuse (DOA)Wednesday   
​​​​​​​2:00 to 3:00
 Tan
Lisa TarantinoAcute locomotor activation and behavioral sensitization to cocaine in the Collaborative Cross and Diversity Outbred mouse populationsWednesday   
​​​​​​​2:00 to 3:00
 Tarantino
Collin TeaguePhosphodiesterase 1b is an Upstream Regulator of a Key Gene Network in the Nucleus Accumbens Driving Addiction-Like BehaviorsWednesday   
​​​​​​​2:00 to 3:00
 Teague
Samikkannu ThangavelHIV-1 Tat and Cocaine Impact Astrocyte Energy Metabolism: Roles of microRNA in Epigenetic RegulationWednesday 2:00 to 3:00 Thangavel
Lani TieuIdentification of individual differences in response to methadone, buprenorphine, and naltrexone in animal models of opioid use disorderWednesday   
​​​​​​​2:00 to 3:00
 Tieu
Dong-Binh TranAssociations between microbiota and novelty behavior in mice with reference to cocaine addictionWednesday   
​​​​​​​2:00 to 3:00
 Tran
Matthew TranSingle-nucleus transcriptome analysis reveals cell type-specific molecular signatures across reward circuitry in the human brainWednesday   
​​​​​​​2:00 to 3:00
 Tran-n
Mudit TyagiCocaine-induced NFAT, NF-kB and AP-1 cooperate in facilitating HIV gene expression and replicationWednesday   
​​​​​​​2:00 to 3:00
 Tyagi
Mallory UdellTailTimer: automating data collection for the rodent tail immersion assayWednesday   
​​​​​​​2:00 to 3:00
 Udell
Hemayet UllahHost Targeted Antivirals Inhibit RACK1 mediated IRES Activities in HIV-1Wednesday   
​​​​​​​2:00 to 3:00
 Ullah
Denong WangModulating ADAR-1 arm of innate immunity for HIV cureWednesday   
​​​​​​​2:00 to 3:00
 Wang-d
Meiyue WangDoes Population Structure Affect Murine Genome-Wide Association Study (GWAS) Results?Wednesday   
​​​​​​​2:00 to 3:00
 Wang-m
Qun WangOrganoids as New Platform to Study Substance Use DisordersWednesday   
3:00 to 4:00
 Wang-q
Tengfei WangGWAS on socially acquired nicotine IVSA in heterogeneous stock rats highlights genes implicated in human smoking behaviorWednesday   
​​​​​​​3:00 to 4:00
 Wang-t
Xingyan WangNear Optimal Trans-ethnic Meta-Analysis of Smoking Phenotypes in 1.3 Million IndividualsWednesday   
​​​​​​​3:00 to 4:00
 Wang-x
Xusheng WangGenetic Architecture of Protein Expression in Rat BrainWednesday   
​​​​​​​3:00 to 4:00
 Wang-xusheng
Brenna WilliamsGenome-wide association study of psychostimulant-induced behavior in Drosophila melanogasterWednesday   
​​​​​​​3:00 to 4:00
 Williams-b
Jin XuCharacterization of an exon 7-associated seven transmembrane C-terminal variant, mMOR-1O, of the mu opioid receptor gene (Oprm1) in a conditional gene targeting mouse modelWednesday   
​​​​​​​3:00 to 4:00
 Xu-jin
An YeLineage Tracing of Human Exosomal microRNAs to Brain Regions Impacted by Cocaine Use Disorder to Develop a Mechanistic Biosignature for Pharmacotherapy ResponseWednesday   
​​​​​​​3:00 to 4:00
 Ye-an
Fengchun YeRegulation of HIV Silencing by Nuclear ReceptorsWednesday   
​​​​​​​3:00 to 4:00
 ye-fengchun
Szu-Ying (Sam) YehThe Role of ∆FosB in the Development of Drug Addiction: Identifying ∆FosB Transcriptional Targets in Nucleus AccumbensWednesday   
​​​​​​​3:00 to 4:00
 Yeh-Sam
Elizabeth YenThe role of sex and inflammation on the developing brain in neonatal abstinence syndrome (NAS)Wednesday   
​​​​​​​3:00 to 4:00
 Yen-elizabeth
Dana ZeidBehavioral and genetic characterization of contextual fear conditioning and related phenotypes using the BxD RI panelWednesday   
​​​​​​​3:00 to 4:00
 Zeid
Jun-Jie ZhangHigh-throughput identification of functional variants in gene enhancers associated with alcohol use disorderWednesday   
​​​​​​​3:00 to 4:00
 Zhang-jun-jie
Xinyu ZhangDeconvolution of bulk DNA methylome and a cell type specific epigenome-wide association study for HIV infectionWednesday   
​​​​​​​3:00 to 4:00
 Zhang-xinyu
Jessica ZhouCell type-specific multiomic analysis of substance use disorders in outbred ratsWednesday   
​​​​​​​3:00 to 4:00
 Zhou-jessica
Xiaoxi ZhuangN6-methyladenosine and Epitranscriptomic Regulation of Learning and Responses to CocaineWednesday   
​​​​​​​3:00 to 4:00
 Zhuang-Xiaoxi
Katerina Zorina-LichtenwalterShared genetic risk factors in pain conditionsWednesday   
​​​​​​​3:00 to 4:00
 Zorina-Lichtenwalter
Elizabeth Zuniga-SanchezIlluminating the molecular mechanisms of drug-induced neuroplasticity using the mouse retinaWednesday   
​​​​​​​3:00 to 4:00
 

Zuniga-Sanchez

 

Abstracts and Agenda from January 2020 meeting
SubmitterTitle of AbstractSession#
AgrawalFindings from the Substance Use Disorders Working Group of the Psychiatric Genetics Consortium4T11
AkbarianA Chromosomal Connectome for Psychiatric and Metabolic Risk Variants in Adult Dopaminergic NeuronsC1
BacanuImputation of summary statistics using large reference panels increases the accuracy and resolution of genetic signals coming from metanalysis of substance use disorderC2
BachtellPhenotypic differences in oxycodone responses in the inbred rat strainsC3
BagleySex Chromosome Complement Influences Voluntary Ethanol Consumption in Adolescent MiceC4
BaileyHeritable variation and genetic correlation of addiction-related phenotypes in the CC/DO recombinant inbred mouse panelC5
BakerDissecting the Genetic Basis of Variation in Cocaine and Methamphetamine Consumption in Drosophila melanogasterC6
BakerSingle-cell transcriptional responses to cocaine exposure in the Drosophila brainC7
BandrowskiAddicted to FAIR data? The role of repositories and reproducibility in improving impact of data in addiction research.6T14
BangasserSex differences in stress inoculation of addiction-like phenotypesC8
BarrPrediction of alcohol and other substance use disorders using a polygenic score for broader externalizing risk.C9
BarryModeling nicotine and smoking exposures in the developing brainC10
BeierleNearly isogenic BALB/cJ and BALB/cByJ substrains differ in opioid state dependent learning, spontaneous withdrawal, and weight loss in response to oxycodone: Planning a reduced complexity cross.C11
BelancioCustom RNA-Seq methods identify tissue- and age-specific patterns of retrotransposon expression in vivo7T18
BerrettiniNeonatal Opioid Withdrawal Syndrome: Observations in a Health SystemC12
BidlackFibroblast Growth Factor 21 Attenuates Morphine-induced Preference, Tolerance, and Dependence Without Affecting AnalgesiaC13
BogueNew tools to assess research replicability using the Mouse Phenome DatabaseC14
BorrelliNeonatal morphine administration (P1-14) in outbred CFW mice induces enhanced behavioral signs of withdrawal in females and a distinct brainstem transcriptomic profile compared to malesC15
BranscomeUse of Stem Cell Extracellular Vesicles as a “Holistic” Approach to CNS RepairC16
Brieño-EnríquezReproductive decline and epigenetic effects of in utero opioid exposureC17
BrowneTranscriptional reprogramming of the brain reward system by heroin self-administrationC18
BubierThe Microbial community dynamics of cocaine sensitization in two behaviorally divergent Collaborative Cross strains.C19
BuckDevelopmental nicotine exposure elicits multigenerational epigenetic anomalies in the frontal cortices, striata, and hippocampi of adolescent mice which co-occur with neurodevelopmental disorder-like phenotypesC20
CadetMimicking methamphetamine use disorder with footshock punishment: epigenetic and transcriptional consequences in the rat brain.9T24
CalarcoThe effect of developmental fentanyl exposure on mitochondrial gene expression in the brain and blood in C57Bl/6 mice9T27
CalipariDivergent molecular adaptations in the nucleus accumbens control cocaine reinforcement in males and females3T7
CatesUsing published datasets to study the role of lncRNA in substance use disordersC21
ChakrabortyGenome to Phenome Implications of Social Stress-Induced Nicotine Preference: A Conspecific Aggressor-Induced Social Stress Model Integrated with a Nicotine Two-Bottle Choice ParadigmC22
ChandraEgr3 regulates mitochondrial nuclear gene expression in nucleus accumbens neuron subtypes after cocaine exposureC23
ChenDeep learning model using network topology of linkage disequilibrium patterns increases the accuracy of polygenic risk scores for smokingC24
CheslerInterpreting human genetics of SUD using multi-species heterogeneous functional genomics data6T15
ChevalierCharacterizing the HIV-1 Proviral Reservoir in ART-treated Opioid UsersC25
ChoiOptically Induced CRISPR Tool for Epigenome Editing in Cocaine ActionC27
ChoquetHeritability Estimate of Postoperative Total Morphine Equivalents in New Persistent Opioid UsersC28
CiborowskiInvestigation of Macrophage proteome exposed to methamphetamine: A Multiple Reaction Monitoring (MRM) approachC29
CowenEffects of Marijuana on Viral Transcription in HIV-1 Infected Cells and Resulting Extracellular Vesicle ReleaseC30
CristDifferential expression and transcription factor binding associated with genotype at a pharmacogenetic variant in OPRD1D1
DamajGenetic Variation in nicotine withdrawal in MiceD2
DattaCocaine self-administration profiles in the Founder Strains of the Collaborative CrossD3
DayA dopamine-induced gene expression signature regulates neuronal function and cocaine response3T9
de JongTowards an infinite genetic map for the rat hybrid diversity panelD4
DemontisThe polygenic risk for cannabis initiation and cannabis use disorder in individuals with cannabis and multiple drug use disorders and comorbid psychiatric disorders2T3
DickUsing the genetic architecture of substance use disorders to aid in gene identification: Findings from the Externalizing Consortium8T21
DonaldsonPredicting Risk of Opioid Addiction: Evaluation of Genetic Factors Using Machine Learning AlgorithmsD5
DrachevaExtensive cell type-specific epigenetic reorganization of the OPRM1 locus in primate evolutionD6
EdenbergUpdates from the Psychiatric Genetics Consortium on Alcohol Use Disorders4T10
EhringerThe role of a priori-identified addiction and smoking gene sets in smoking behaviorsD7
ElamGenotype-Environment Correlation by Intervention Effects Underlying Middle Childhood Peer Rejection and Associations with Adolescent Marijuana UseD8
EngelnTranscriptional adaptations in the ventral pallidum following cocaine self-administrationD9
EvansInvestigating Genetic Susceptibility to Tobacco Smoking at rs16969968 based on Age at Onset of Regular SmokingD10
FengNeuron subtype specific role of DNA methylcytosine dioxygenase TET1 in cocaine addictionD11
FloresThe DCC gene network in the prefrontal cortex and striatum as a predictor of cognitive control and psychopathologyC26
FowlerNicotine Mediates Extracellular Vesicle RNA Signaling in the Brain3T8
FoxNeuron subtype specific structural and molecular changes following fentanyl abstinenceD12
GainesIdentification of a genetic locus and environmental factors influencing initial cocaine sensitivity in C3H substrainsD13
GaneshWho dare-not smoke-pot – Can schizophrenia polygenic risk predict acute psychotic response to cannabis?D14
GoldbergSystems Genetic Analysis of Nicotine Withdrawal Deficits in Learning Using the BxD Genetic Reference PanelD15
HaasGenome-wide association studies of substance use in people living with HIV across the USD16
HagenauerA Meta-Analysis of Hippocampal Transcriptional Profiling Studies in a Selectively-Bred Rat Model Converges with Genetic Sequencing to Implicate Specific Candidate Genes and Pathways in the Liability for Internalizing8T22
HanUnbiased genetic screen identifies the novel molecules critical for inhibitory controlD17
HatoumPolygenic Risk Scores for Commonly Used Substances Predict Brain Structural differences in Drug Naïve ChildrenD18
HazelEpigenetic variation in neurons from multiple brain regionsD19
JacobsonDigging Deeper: Tackling the Complexity of Genetics and Molecular Mechanisms for Addiction in Human and Model Organism Populations6T17
JeeGenetic basis of Nicotine seeking behaviors in C. elegansD20
JohnsonMeasures of consumption versus disordered substance use: evidence of different genetic architectures2T6
JohnsonNIDA Genetics Consortium Genome-wide Association Study of Opioid Addiction – The Endgame for Wave 1.4T12
KallupiCharacterization of addiction-like behaviors to cocaine in Heterogenous Stock rats: Identification of two populations of resistant and vulnerable ratsD21
KapoorIntegrative analysis of omics summary statistics to identify genes associated with substance use disordersD22
KaramThe genetic basis of natural variation in amphetamine sensitivity in DrosophilaD23
KaulCalbindin- and parvalbumin-positive neurons and microglia display sexual dimorphism in long-term responses to methamphetamine and HIV-associated brain injuryD24
KimHigh-Throughput Screening of Circadian Rhythms and Strain-Dependent Relationships with Cocaine Addiction in Genetically Diverse Mouse PopulationsD25
KozlovaUnderstanding the molecular basis of nicotine addiction by integrative functional genomic analyses in a rat model and hiPSC-derived DA neuronsD26
KuhnIndividual variation in addiction-related behaviors contributes to opioid dependence vulnerabilityD27
KumarForward genetic ENU mutagenesis screen in mice identifies SrGAP3 as a regulator of cocaine responsesD28
KumarKockout Mouse Project (KOMP2) has a discovery engine for novel addiction genesD29
LiaoThe International Complex Disease Alliance5T13
LinDopaminergic Epistasis: Substance Use Disorders vs. Parkinson's DiseaseD30
LoganTranscriptional signatures in the human postmortem brain reveal associations between molecular rhythm disruptions and opioid use disorderA1
LuTransferring the Knowledge between Different Populations and Species by Using a Functional Deep Neural NetworkA2
MathisSeptal inputs to habenula regulate nicotine craving9T26
MaturinThe Cocaine and Oxycodone Biobanks: Two repositories of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of cocaine or oxycodone self-administrationA3
MewsEpigenetic priming underlies transcriptional disruption linked to cocaine relapseA4
MeyersAssociation of Polygenic Liability for Cannabis Initiation and EEG Connectivity in Adolescence and Young AdulthoodA5
MiaoIntegrative analysis of epigenetic response to Methamphetamine overdose in rat brainA6
MitchellLumping splitting and evolving: Strategies to characterize behavioral phenotypes associated with substance useA7
MohanLong term delta-9-tetrahydrocannabinol administration inhibits neuroinflammation in chronically SIV-infected rhesus macaques through regulating interferon responses and miRNA mediated pathwaysA8
MoszczynskaLINE-1 on the Move: A Report on Regional Differences in Brain LINE-1 Activity after Chronic Methamphetamine AdministrationA9
MummidiRNA binding protein HuR regulates CCL2 allelic expression imbalanceA10
NadeauPhenotypic Noise, the missing dimension of phenotypic variation and disease riskA11
NealeMultilevel Causal Genetic Modeling in the ABCD DatasetA12
NelsonA GWAS of Opioid Withdrawal Symptom ClustersA13
OdegaardTransgenerational epigenetic inheritance associated with prescription opioids abuse: Like mother, like child?A14
PalmerShared Sources of Genetic Variation Underlying the Transmissible Liability Index for Substance Use Disorders and Subsequent Cannabis UseA15
PalmerMulti-trait Polygenic Prediction of Nicotine and Alcohol DependenceA16
PalmerComparative Neuro-Transcriptomics of Alcohol Use and DependenceA17
PalmerAll of us for rats: multiomic studies of addiction-related traits in outbred ratsA18
PanMu opioid-induced biased signaling through mu opioid receptor seven transmembrane full-length C-terminal splice variantsA19
ParkerMeasuring negative affective withdrawal in CFW mice: Implications for GWASA20
PathakGenetic association of phenotypic typologies of polysubstance use disorders: A latent class approachA21
PayerAlu retrotransposon: A common structural variant that can regulate transcript level and structure leading to disease risk7T19
PeltzComputational Genetic Analysis of 8300 Biomedical Phenotypes and of Responses to Drugs of AbuseA22
PeriyasamyHIV Tat and morphine-mediated activation of astrocytes: Epigenetic involvement of NLRP6 inflammasome in HANDA23
PetersonRepresentation of diverse populations in addiction genetics: a call to action.A24
PfenningAddiction-associated genetic variants implicate cell type- and region-specific cis-regulatory elements in addiction neurobiology9T25
PhilipGenetic correlations and quantitative trait locus mapping reveals shared and unique mechanisms underlying addiction predisposing novelty response traitsA25
PolimantiLeveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium2T5
QuachSmoking-dependent expression QTL evidence in human nucleus accumbens among variants identified by the GSCAN consortiumA26
RamseyDesign and preliminary test of a personalized genetic risk tool to promote smoking cessationA27
ReinerL1 Retrotransposons in Psychiatric and Substance Use Disorders7T20
ReynoldsIntegrative cross-species analysis uncovers convergent genomic regulatory features associated with complex diseaseA28
RiceSmokeScreen: A GWAS resource for Substance AbuseA29
RichardsReduced Intake When Drugs Make You ColdA30
RogersValidation of a Large-Scale Dynamical Model of Macrophage/HIV Interaction for the Mathematical Analysis of Methamphetamine Emergent/Epigenetic Effects on HIV/AIDS Disease Progression Using Visual Statistical InferenceB1
RothenfluhMechanisms of cocaine aversion in DrosophilaB2
RuanStriatal transcriptome-wide profiling of hnRNP H RNA-binding targets via CLIP-seq in response to methamphetamine identifies Oprk1 as a potential translational target underlying reduced behavior in Hnrnph1 mutant miceB3
RutherfordRecovery Vital Signs1T1
SabaGenetic differences in estrous cycle effects on the rat brain transcriptomeB4
SalvatoreSocial genetic effects for alcohol use disorderB5
Sanchez-RoigeAlcohol consumption and misuse have a distinct genetic basis2T2
SchoenrockGenetic dissection of initial drug sensitivity and behavioral sensitization using the Collaborative Cross and Diversity Outbred mouse populationsB6
SedighimHS rats with high addiction-like behaviors choose cocaine over palatable food in a discrete choice testB7
SeemillerNicotine Metabolism Genetics in C57BL/6J and NOD/ShiLtJ mouse strainsB8
ShtutmanDrugs repurposing for the treatment of HIV-Associated Neurocognitive Disorder by AI-based literature miningB9
SumnerThe Internal Exposome, Opium Use, and Opioid Use Disorder2T4
TeleseCell-type specific gene expression changes associated with adolescence exposure to THC in miceB10
TeleseSequencing newly initiated transcripts to study transcriptional regulatory mechanisms in substance use disordersB11
ThangavelEpigenetic Modification of Mitochondrial DNA in the Development of NeuroAIDSB12
TroianiValidation of a DSM-5 OUD severity score derived from health record reviewB13
TroianiMeasuring Quantitative Traits of Alcohol Use Disorder in an Integrated Health SystemB14
TyagiCocaine promotes HIV gene expression and replication by co-stimulating NFAT, NF-kB and AP-1, as major transcription factors.B15
VassilevaAssociations of polygenic risk scores with neurocognitive and psychiatric phenotypes in Bulgarian substance usersB16
VerhulstAnalyzing latent propensities to addictive behaviors in a multivariate GWAS framework using GW-SEM.8T23
WalkerAdolescent Stress Results in Sex-Specific Reprogramming of the Reward Circuitry Transcriptome in AdulthoodB17
Walss-BassDemyelination and Accelerated Aging as Mechanisms of Cocaine-induced NeurotoxicityB18
WeinstockInfluence of the microbiome on novelty behavior and cocaine addiction in mouse models.B19
WeissSuccessful Illumina Array Genotyping on Serum Stored For Three DecadesB20
WilliamsGenome-wide association study of psychostimulant-induced behavior in Drosophila melanogasterB21
WimmerTranscriptomics associated with opioid craving in the nucleus accumbens of male and females Long Evans ratsB22
WolstenholmeAdolescent binge ethanol slows oligodendrocyte maturation through regulation of histone methylation in the PFCB23
WonElucidating the neurobiological bases of cigarette smoking and nicotine dependence6T16
YadidPLX-PAD placental derived mesenchymal like adherent stromal cells as an effective cell therapy for cocaine addiction in a rat modelB24
ZhangIn silico Epitope Mining and the Search for a Universal Carrier ProteinB25
ZhangAn Efficient Method for Global Gene Regulatory Network ConstructionB26
ZhangEpigenome-wide DNA Methylation Profiling: Methylation Capture Bisulfite Sequencing versus Infinium MethylationEPIC BeadChipB27
ZhangMicroRNAs regulate the transgenerational impact of nicotine exposure and smokingB28
ZhongAlcohol-induced histone H3 phosphorylation modulates deregulation of Brf1 and tRNA genes in hepatocellular carcinomaB29
ZlebnikCannabinoid exposure in adolescence dysregulates genes that orchestrate dopamine development and alters cocaine-motivated behaviorB30

 

Abstracts and Agenda from January 2019 meeting

Abstracts

SubmitterTitle of AbstractSession#
Arpana AgrawaiUpdates from the Psychiatric Genomics Consortium's Substance Use Disorders Working Group5T11
Schahram AkbarianEpigenome Profiling in Prefrontal Cortex Neurons Exposed to Opiates4T9
David Alvarez-CarbonellVirus on the brain: Inflammation and cross-talk between microglia and neurons regulate HIV latencyD40
Robert AnholtGenetic Variation in Alcohol Induced Modulation of Drosophila snoRNAsD39
Venkata AtluriMagneto electric nanoparticle based CRISPR-Cas9/gRNA delivery to eradicate latent HIV infection and neuropathology in the brainD38
Silviu-Alin BacanuNovel pathway transcriptomics method greatly increases detection of molecular pathways associated with substance use disorderD36
Silviu-Alin BacanuDirect imputation of summary statistics using large reference panels increases the resolution of genetic signals coming from metanalysis of substance use disorderD37
Jared BagleyHeritable variation in voluntary alcohol drinking and blood ethanol concentrations in a genetically diverse inbred mouse panelD35
Brandon BakerDissecting the Genetic Basis of Variation in Cocaine and Methamphetamine Consumption in Drosophila melanogasterD34
James BaurleyPrediction of nicotine biomarkers from genotypesD33
Jacob BeierleMouse inbred strain survey of oxycodone addiction traits in an opioid multi-stage addiction assessment protocolD32
Chelsie Benca-BachmanCross-Species Prioritization of Genomic Loci for Nicotine Consumption9T15
Andrew BergenBiosignatures of Opioid Addiction Treatment Success (BOATS)D31
Wade BerrettiniElectronic Health Records in Evaluating the Potential for Opioid Use Disorder2T4
Jinbo BiInferring Phenotypes from Substance Use via Collaborative Matrix CompletionD30
Jean Bidlack   Fibroblast Growth Factor 21 Attenuates the Preference for Morphine in a Conditioned Place Preference AssayD29
Stephanie BielasGenetic regulation of personalized opioid response in cerebral organoidsD28
Molly BogueMouse Phenome Database 2.0: New tools and data resources for curated and integrated primary mouse phenotype dataD27
Kristyn BorrelliReward sensitivity in Hnrnph1+/- mice following acute methamphetamine administration as measured via intracranial self-stimulationD26
Caroline BrennanPopulation based forward genetic screen of mutagenized zebrafish identifies loci associated with nicotine preference and human smoking behaviorD25
Camron BryantGene mapping and editing of an intronic variant in Gabra2 in methamphetamine sensitivity and naloxone-induced aversion behaviors in a reduced complexity crossD24
Jason BubeirGenetic Variation in Opioid Induced Respiratory Depression in MiceD23
Matthew BuczynskiEnhanced nicotine reward in a mouse model of the P129T FAAH gene polymorphismD22
Hannah CatesRevealing the chromatin-bound long noncoding RNA landscape of the brainD21
Marta CekoPredicting placebo analgesia - literature review and new perspectivesD20
Ramesh ChandraCocaine-induced histone methylation on Egr3 and Nab2 promotersD19
Renchao ChenTranscriptome and functional characterization of nucleus accumbens neurons reveal Tac2+ D1 neurons in regulating psychostimulant effect of cocaineD17
Hao ChenIntermittent oral oxycodone self-administration in inbred strains of rats is heritableD18
Shuo ChenLarge-scale mediation analysis to identify gene-brain network-nicotine addiction pathways using imaging-genetics data6T16
Vidya ChidambaranBiopsychosocial clusters based on genetic risk scores for chronic post-surgical pain in children undergoing spine fusionA42
Hélène ChoquetGenetic Ancestry and Tobacco Smoking BehaviorD16
Pawel CiborowskiSecreted metabolome of methamphetamine treated human primary macrophagesD15
Olivia CorradinIdentifying pathogenic cell type of disease associated variantsB39
M. Imad DamajA comparative phenotypic analysis of nicotine pharmacological effects and dependence behaviors in C57BL/6J and C57BL/6N mouse strainsD13
M. Imad DamajStrain-Dependent Oral Nicotine Intake Using a Free-Choice Paradigm in MiceD14
Michael DappImpact of HIV and Methamphetamine Use on the Nucleome in Individuals on Antiretroviral TherapyD12
Prasun DattaModulation of glutamate transporter, EAAT2 expression by epigenome editing.D11
Giordano de GuglielmoNociceptin/orphanin FQ reverses the escalation of oxycodone self-administration by normalizing GABA transmission in the amygdala in rats with high addiction-like behaviorsD10
Catherine DeMarinoEffects of Marijuana on Viral Transcription in HIV-1 Infected Cells and Resulting Extracellular Vesicle ReleaseD9
Price DicksonSystems genetics discovery of genetic, genomic, and gene-by-environment mechanisms driving substance use and sensation seekingD8
Stella DrachevaThe role for DNA (hydroxy)methylation in epigenetic regulation of different brain cell types4T8
Jubao DuanUnderstanding the molecular basis of nicotine addiction by integrative genomic analyses in a rat model and hiPSC-derived DA neuronsD7
Howard EdenbergUpdate from the Psychiatric Genomics Consortium: Alcohol5T12
Marissa EhringerInbred Mouse Strains Selected for High and Low Open Field Activity Also Show Differences in Alcohol-Related BehaviorsD6
Kit ElamUsing Gene Set Enrichment Analysis to Create Polygenic Risk Scores for Childhood Aggression: A Developmental ExaminationD5
Nazira El-HageMorphine counteracts the antiviral effect of antiretroviral drugs and causes upregulation of p62/SQSTM1 and histone modifying enzymes in HIV-infected astrocytesD4
Michel EngelnTranscriptional adaptations in the ventral pallidum following cocaine self-administration.D3
Dan FabrisExploring the CNS Epitranscriptome by MS-Based ApproachesD2
Jian FengNeuron subtype-specific role of methylated DNA cytosine dioxygenase TET1 in cocaine addictionD1
Abdelali Filali-MouhimNon-coding RNAs drive increased fatty acid synthesis and reduce inflammation in cART treated HIV infected cocaine usersC42
Hannah FryeCNIH3 expression in female mice modulates hippocampal synapse stability and AMPAR-dependent memory and learning C41
Suhas GaneshMolecular intersections of cannabis exposure and psychosis expression using patient derived HiPSC neuronsC40
Hugh GaravanENIGMA-Addiction: Gene-brain associations with SUDC39
Olivier GeorgeThe Oxycodone Biobank: A repository of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of oxycodone self-administrationC38
Jonathan GewirtzWithdrawal-induced anhedonia as a protective factor in opioid addictionC37
Reza GhanbariAn Untargeted NMR‐based Metabolomics Analysis to Investigate the Urinary Metabolites in Opium UsersC36
Nathan GillespieGWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophreniaC35
Lisa GoldbergIdentification of a Locus on Chromosome Four Mediating Nicotine Withdrawal Deficits in Hippocampal LearningC34
Judy GriselEx-Differences in Drug Sensitivity: Gonads or Non-coding RNAs?C33
Purnima GuptaMagnetically guided non-invasive nanoformulations of Cas9/gRNA complemented with Opioid antagonist: A novel approach targeting HIV reservoirs in the brain7T17
F. Kent HamraKnockin Rat Model Production by Germline Gene Targeting in Sperm Stem CellsC32
Kyung-An HanImpulsive flies shed light on new players for dysfunctional inhibitory controlC31
Dana HancockGenome-wide DNA methylation differences in nucleus accumbens of smokers vs. nonsmokersC30
Elizabeth HellerChromatin-directed alternative splicing in brain reward regions7T19
Chad HighfillGenetics of Cocaine and Methamphetamine Consumption and Preference in Drosophila melanogasterC29
Terry HindsE-cigarette nicotine exposure increases hepatic fat content reducing liver-derived fuel for the brainC28
William HoffmanTrace Amine Associated Receptor 1 (TAAR1) SNP rs8192620 is associated with increased craving and altered striatal functional connectivity in methamphetamine use disorder (MUD)C27
Rebecca HoffordThe gut microbiome as a homeostatic regulator of striatal gene expression in response to opioidsC26
Mingi HongGene-environment interactions in holoprosencephalyC25
Goku HuExtracellular Vesicle-mediated small RNA delivery into the CNSC24
Jun HuangThe histone methyltransferase EZH2 primes the differentiation of follicular helper T cells during acute viral infectionC23
Jordan HugheyFine Mapping Causal Variants of Smoking and Drinking Addiction Related TraitsC22
Ovidiu IancuNetwork Approaches Identify Brain Regions and Gene Hubs Associated with Genetic Predisposition for Methamphetamine IntakeB10
Hae Kyung ImExploring the mechanism behind drug addiction integrating predicted transcriptomic and radiomic dataC20
Changhoon JeeCompulsive behaviors in C. elegans as a model to study Substance Use DisordersC19
Emma JohnsonLarge genome-wide association study of cannabis abuse and dependence: an update from the PGC Substance Use Disorders working groupC18
Eric JohnsonNIDA Genetics Consortium Genome-wide Association Study of Opioid Addiction – An Update.5T13
Marsida KallupiPharmacological treatments for opioid dependence in Heterogeneous Stock ratsC17
Helen KamensAdolescent social stress influences later ethanol and nicotine behaviors and microRNA expressionC16
Jaakko KaprioA Genome-wide association meta-analysis of the nicotine metabolite ratio and five other smoking related traits in smokers of European descentC15
Caline KaramFlying high: Delineating the genetic basis of amphetamine sensitivity using a Drosophila behavioral modelC14
Marcus KaulNeurotransmission-related gene expression reveals sexual dimorphism in long-term effects of methamphetamine and HIV-associated brain injuryC13
Pamela KennedyEpigenetic mechanisms mediating cocaine-induced shifts from hippocampal to dorsolateral striatal behavioral learning and controlC12
Paul KennyHabenular Tcf7l2 links nicotine addiction to diabetes2T13
Srivatsan KidambiMETH elicits dose- and time-dependent autophagic cytotoxicity in primary astrocytesC11
Sam-Moon KimStrain Differences of Molecular Circadian Rhythms in Primary Fibroblasts Derived from Founders of Collaborative Cross and Diversity Outbred MiceC10
Zachary KlaseDrugs of abuse as drivers of epigenetic change in HIV-1 infectionC9
Albert KsinanExternalizing and Internalizing Genetic Pathways to Alcohol Consumption and Alcohol Use Disorder Symptoms in College StudentsC8
Vivek KumarIntegrated analysis of JAX-KOMP2 data reveals a cluster of genes predictive of addiction phenotypes.C7
Meena KumariDo exosomes hold the key to genetic and epigenetic modifications in drug addiction?C6
Tuuli LappalainenFunctional variation in the human genome: lessons from the transcriptome3T5
Casey LardnerElucidating the cell type-specific transcriptional patterns differentiating stimulant versus opiate addictionC5
Kaycie LawsonMethamphetamine alters innate immune signaling by inducing an IL-1β-miR-146a negative feedback loop and contributes to anti-retroviral drug resistance in CD4+ T-cellsC4
Jun LiGenetics of Novelty Seeking and Propensity for Drug Abuse in Outbred RatsC2
Yanchun LiThe histone demethylase KDM6B in the medial prefrontal cortex epigenetically regulates cocaine reward memoryC3
Xiaoyu LiangDNA methylation signature of Phosphatidylethanol Predicts Hazardous Alcohol UseC1
Yunlong LiuAlcohol Abuse Associated Allele Specific Expression and Regulation in Human Brain TissueB41
Dajiang LiuPhenotype imputation integrating GWAS summary association statistics, deeply phenotyped cohorts and large biobanks Identifies novel loci for cotinine levelsB42
Jingyu LiuOpposite Epigenetic Modifications between Alcohol Use and Exercise InterventionB40
Qing LuA Kernel-Based Neural Network for High-dimensional Risk Prediction on Massive Genetic DataB38
Rui LuoTransgenerational Effect of Smoking During Pregnancy on DNA Methylation of the NewbornB37
Morteza MahmoudiDevelopment of Innovative Protein Corona Nanosystem Technology for Early Detection of Substance Abuse DisordersB36
Travis MallardInsights into the multivariate genetic architecture of externalizing spectrum behaviors and disorders: Preliminary results from the Externalizing ConsortiumB35
Aimee Manzoni-D'ArpinoA Parent’s Perspective: Personal Stories of Substance Use Disorder1T1
Maria MarcondesStable histone modifications in post-mortem brain tissue can help overcome quality issues to help identify neuroHIV signaturesB34
Christina MarkunasEpigenome-wide analysis uncovers a blood-based DNA methylation biomarker of lifetime cannabis use.B33
Lisa MaturinThe Cocaine Biobank: A repository of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of cocaine self-administrationB32
Paul McLarenPolygenic analysis of genome-wide genotype data reveals genetic overlap between HIV acquisition and addiction traitsB31
Raghu MetpallyGenomic analyses of prescription opioid dose in chronic opioid exposureB30
Philipp MewsEpigenetic priming underlies transcriptional dysregulation in cocaine addiction4T10
Jacquelyn MeyersPolygenic Influences on Alcohol Related Neurophysiological and Neurocognitive Processes across the LifespanB29
Michael MilesGenetic Analysis of Intermittent Access Ethanol Consumption in Diversity Outbred (DO) MiceB28
Mahesh MohanLong noncoding RNA landscape in the intestinal epithelium of delta-9-tetrahydrocannabinol treated chronically SIV-infected rhesus macaquesB27
Kevin MorrisRecombinant protein guided activation of HIV; a means for target specific purging of proviral reservoirs in the brainB26
Megan MulliganIdentification of Sex, Strain, and Entourage Effects in the Behavioral and Physiological Response to CannabinoidsB25
Joe NadeauThe mean-ness of noisy biological systemsB24
Michael NealeEffects of Age, Sex and Race on Substance Abuse and Dependence AssessmentsB23
Elliot NelsonA GWAS of Opioid Withdrawal Symptom CountB22
Katherine OdegaardTransgenerational transcriptomic changes associated with prescription opioids abuse: How far has the apple fallen from the tree?B21
Abraham PalmerCenter for genetic studies of drug abuse in outbred ratsB20
Rohan PalmerCross-Species Prioritization of Genomic Loci for Drug Addiction: An Example Using Alcohol Consumption3T6
Sarah PalumboElectronic Health Records in Evaluating the Potential for Opioid Use DisorderB19
Ying-Xian PanPharmacological functions of alternatively spliced mu opioid receptor variants in conditional Oprm1 rat models generated by Easi-CRISPRB17
Ying-Xian PanAlternatively spliced mu opioid receptor intracellular C-termini encoded by exon 7 are important for fentanyl actionsB18
Clarissa ParkerMeasuring negative affective withdrawal in CFW mice: Implications for GWASB16
Gary PeltzComputational Genetic Discovery for SUD2T2
Palsamy PeriyasamyCocaine-mediated microglial activation involves miR-148b-lncRNA XIST-DNMT1 axis-mediated epigenetic promoter DNA methylation of an anti-inflammatory gene, PPARGB15
Roseann PetersonCross-ancestry Genome-wide Analyses of Substance Use Behaviors in Schizophrenia: Findings from the Genomic Psychiatry Cohort.B14
Renato PolimantiGenome-wide association study of opioid dependence from the Psychiatric Genomics ConsortiumB13
Dar’ya PozhidayevaEffects of Chronic Stimulation of Nucleus Accumbens on Binge Drinking and TranscriptomeB12
Rebecca ProsserPaternal cocaine consumption in mice sex-specifically alters F1 offspring cocaine preference, circadian rhythm responses, and striatal gene expression.B11
Benjamin ReinerL1 retrotransposons in cocaine addiction7T18
Tamara RichardsA Single Nucleotide Replacement Restores Methamphetamine Traits to Low Addiction Risk LevelsC21
Jim RogersLarge Scale Dynamical Model of Macrophage/HIV Interaction for the Mathematical Analysis of Methamphetamine Emergent/Epigenetic Effects on HIV/AIDS Disease ProgressionB9
Qiu RuanCLIP-seq analysis of the RNA binding protein hnRNP H in striatum following methamphetamine administration in Hnrnph1+/- miceB8
Sarven SabunciyanRepetitive Element Expression is Altered in the Brain Following Glucocorticoid ExposureB7
Sandra Sanchez-RoigeAlcohol consumption vs. misuse: evidence for distinct genetic architecture6T14
Michael SaulGenetics and sex govern the striatum transcriptional response to cocaineB6
Sarah SchoenrockQTL mapping for initial sensitivity to cocaine using an F2 intercross of low and high responder inbred strainsB5
Michael ShtutmanInhibition of the DEAD Box RNA Helicase 3 prevents HIV-1 Tat- and cocaine-induced neurotoxicity by targeting microglai activationB4
Chang ShuPeripheral blood DNA methylation markers are associated with HIV progressionB2
Chang ShuEpigenome-Wide Association Scan (EWAS) of opioid use among chronic injection drug users and in a post-mortem opioid overdose brain sample.B3
Susan SmithCollaborative Cross RIS as a Mouse Model to Identify Genetic Polymorphisms that Modify Alcohol-Related OutcomesA41
Ryan SmithMapping Cell Types in the Human Putamen from Cocaine AbusersB1
Mallory StephensonDescribing Polygenic Associations for Alcohol Use, ADHD Symptoms, Cigarette Use, and Educational Attainment: A Within-Family Comparisons Study.A40
Jinni SuInteractive Effects Between Polygenic Risk and Social Support in Relation to Alcohol Dependence Symptoms Among European American and African American AdultsA39
Bethany SumpMolecular Mechanisms for Epigenetic Transcriptional Poised Memory StateA38
Boris TabakoffDoes the liver or the brain control voluntary alcohol consumption: using the HRDPA37
Andrew TalalUnderstanding How HIV and Hepatitis C Virus (HCV) Infection Affects CYP2B6 Enzymatic Activity and Methadone PharmacokineticsA36
Lisa TarantinoInitial drug sensitivity and sensitization in the Collaborative Cross/Diversity Outbred foundersA35
George TaylorSelectively bred rats with low motivation to exercise may also be vulnerable to abuse drugsA34
Samikkannu ThangavelCocaine and HIV- Tat Impact Brain Energy Metabolism: Role in Mitochondrial Epigenetic Signature of DNA MethylationA33
Jay TischfieldThe NIDA Genomics Center UpdatedA32
Joey TrampushGWAS of Cognitive Abilities and Risk for Substance AbuseA31
Vanessa TroianiQuantitative Traits Associated with Opioid Use DisorderA30
Jill TurnerAltered Microglial Transcriptomic Changes and Signaling in the Nucleus Accumbens during Nicotine WithdrawalA29
Mudit TyagiCocaine-stimulated signaling pathways enhance HIV gene expression by inducing the establishment of euchromatin structure via modulating the recruitment of different epigenetic enzymes at HIV LTR.A28
Kathryn VaillancourtCocaine-related DNA methylation of IRX2 alters local 3D chromatin architecture in human brain cells.A27
Eric VallenderGene expression in the prefrontal cortex associated with impulsivityA26
Jasmin VassilevaMachine learning reveals common and specific predictors of alcohol, cannabis, and nicotine dependenceA25
Brad VerhulstDeveloping Genome-Wide Structural Equation Modeling (GW-SEM) to analyze the genetic associations with substance use phenotypesA24
Consuelo Walss-BassEpigenetics of Cocaine Use Disorder: A Collaborative Case-Control Initiative in Blood and BrainA23
Qun WangOverdosed Vitamins Generated Epigenetic Changes to Intestinal Stem CellsA22
Nathaniel WeathingtonAssessing the impact of opioid exposure on lung immune function and in acute ICU care after drug overdoseA21
George WeinstockMicrobes, Novelty-Related Behavior, and Cocaine AddictionA20
Jenny WilkersonNon-coding RNAs as markers of opioid use and pathological painA19
Jessica Williams-NguyenThe importance of measuring substance use: A Mendelian randomization of chronic Hepatitis C and myocardial infarctionA18
Katherine WilsonCocaine-induced remodeling of the nuclear lamina and 3D genome organization in neurons?A17
Mathieu WimmerThe apple never falls far: paternal exposure to morphine has deleterious consequences on male progenyA16
Fred WolfA transcriptional control pathway for behavioral plasticity induced by ethanolA15
Jennifer WolstenholmeNeighbor housing alleviates the behavioral and neurobiological consequences of social stress-induced drinking in a sex-dependent mannerA14
Hyejung WonFunctional genomics resources for the human brain elucidates the neurobiological basis of schizophrenia. A13
Christina WooNew chemical tools to elucidate the genetics and epigenetics of opioid addictionA12
Marcelo WoodEpigenetic mechanisms in the medial habenula control reinstatementA11
Han XieValidated Antibody Database: a curated database of antibodies cited in formal publicationsA10
Gal YadidDialogue between epigenetic mechanisms and microbiome in the progress of drug addicts' rehabilitationA9
Fengchun YeModulation of HIV-1 replication in microglial cells by the competing orphan nuclear receptors Nurr1 and Nor1A8
Xinyu ZhangFeature Selection of Smoking-Associated DNA methylation for Prediction on HIV Prognosis and MortalityA4
John ZhangExtracellular Vesicle miRNA Screening On-Chip: Technology, Progress and Potential Application in Opioid Abuse ScreeningA5
Bo ZhangRevealing the dynamic epigenetic changes of nucleus accumbens induced by methamphetamine overdoseA6
Baohong ZhangNicotine exposure caused significant transgenerational impact on microRNA expression and related disorder in C. elegansA7
Mike ZhangThe influence of carrier proteins on the immunological efficacy of nanoparticle-based vaccines against nicotine addictionA3
Wei ZhangA global transcriptional network connecting noncoding mutations to changes in tumor gene expression3T7
Shuping ZhongRole of epigenetic regulation by histone H3 phosphorylation in non-coding RNA, tRNA transcription of breast cancerA2
Xiaoxi ZhuangN6-methyladenosine and Epitranscriptomic Regulation of Learning and Responses to CocaineA1

 

NIDA Genetics Consortium Meeting, June 16, 2018 - UCSD Campus
Abstracts & Agenda from January 2018 meeting
SubmitterTitle of AbstractSession
Hiba AbloushiGenome Wide Association Study of Substance Use Disorder in the United Arab Emirates populationA
Bianca AcevedoGenetic markers underlying the natural addiction of loveC
Balasubrahmanyam AddepalliProbing stress-induced effects on RNA and post-transcriptional modifications by LC-MSB
Arpana AgrawalUpdate from the Psychiatric Genetics Consortium2
Marisela AgudeloSingle cell imaging flow cytometry as a novel epigenetic tool to detect post-translational modifications and extracellular histone release induced by substance abuseB
Schahram AkbarianNuclear transcriptome and 3D genome mapping in dopaminergic neurons of adult human midbrain4
Ethan AndersonThe histone methyltransferase G9a in the nucleus accumbens bidirectionally controls cocaine self-administration, stress-induced reinstatement, and anxiety-like behaviorsA
Silviu-Alin BacanuNovel pathway transcriptomics method greatly increases detection of molecular pathways associated with the drugs traitsB
Jared BagleyHeritable variation in voluntary alcohol drinking in a genetically diverse inbred mouse panelC
Lauren BaileyHeritable variation in reward sensitivity and impulsive action and choice in a genetically diverse inbred mouse panel5
Brandon BakerDissecting the genetic underpinnings of cocaine and methamphetamine consumption in Drosophila melanogasterA
Sarah BarryHistone deacetylase 5 nuclear localization mediates epigenetic changes that limit drug reward and suppress relapse to drug-seekingA
James BaurleyUsing artificial intelligence for learning substance use disorder biosignaturesC
Andrew BergenTobacco use disorder treatment biomarkersA
Jill BettingerSWI/SNF chromatin remodeling complexes are required for normal behavioral responses to acute ethanol exposureD
Junaid BhattiImpact of Genetic Polymorphisms on Opioid Misuse: A Scoping ReviewC
Jinbo BiA Genome-wide Association Analysis with Cocaine Use Disorder Accounting for both Phenotypic Heterogeneity and Gene-Environment InterplayD
Jinbo BiCollaborative Phenotype Inference from Comorbid Substance Use Disorders and GenotypesD
Kenneth BlumGenetic Addiction Risk Score (GARS) Predicts Severity, Relapse & Personalized MedicineB
Camron BryantCyfip1 haploinsufficiency increases compulsive-like behavior and food consumption: Parent-of-origin effects and potential implications for Prader-Willi SyndromeA
Camron BryantFine mapping of a distal chromosome 1 region influencing opioid addiction traits in a reduced complexity crossD
Jason BubierDetecting genetic variation in morphine LD50 in founder strains of the Collaborative Cross and Diversity Outbred mouse populations7
Shilpa BuchHIV-1 Tat-mediated upregulation of miR-34a activates NF-κB-mediated microglial inflammation via targeting the 3′-UTR of NLRC5A
Nicole CameronMaternal and Paternal Lineage Contributions to Transgenerational Effects of Prenatal Alcohol ExposureC
Dana CarrollNicotine Metabolite Ratio and Biomarkers of Exposure among American Indian Tobacco UsersA
Gregory CarterModeling Pleiotropy and Epistasis to Understand Genetic Complexity1
Hannah CatesAccumbal E2F3a mediates cocaine behaviors via transcriptome-wide regulation of gene expression and alternative splicing7
Ramesh ChandraCocaine-induced histone methylation on Egr3 and Nab2 promotersB
Sidi ChenDeveloping direct in vivo genome editing and screening platforms in the mouse brain5
Hao ChenSocial behavior and anxiety predicts nicotine self-administration in adolescent outbred ratsA
Li-Shiun ChenGenetic risk, nicotine dependence, and the clinical benefit of cessation pharmacotherapyD
Christine ChengMassively parallel single-nucleus transcriptomic profiling to identify dysregulated gene regulatory circuitry in opioid addicted human brain8
Elissa CheslerHeterogeneous functional genomics data integration for addiction biology5
Doo-Sup ChoiAdolescence Chronic Caffeine Exposure Promotes Diurnal, Biphasic Mood Cycling and Reduces Dendritic Pruning Through DNA Epigenetics in MiceA
Pawel CiborowskiSystems Biology Approach to Investigate Epigenetic Regulation of Macrophages Exposed to HIV Infection and MethamphetamineC
Shaunna ClarkHuman alcohol brain methylation and biomarker discovery projectA
David CordovaThe Preliminary Efficacy of a Technology-Based HIV and Drug Abuse Preventive Intervention in a Youth-Centered Community Health Clinic: Opportunities for Incorporating Biomarkers of Exposure and Genetic SusceptibilityA
Olivia CorradinIdentifying pathogenic gene targets of noncoding GWAS risk loci using gene regulatory circuitsD
Richard CristReplication of the pharmacogenetic effect of rs678849 on buprenorphine efficacy in African-Americans with opioid use disorderB
Matthew DalvaExtracellular Phosphorylation of a Receptor Tyrosine Kinase Controls Synaptic Localization of NMDA Receptors and Regulates Pathological PainD
Imad DamajCyfip2 plays an important role in nicotine reward in miceA
Mariella De BiasiThe CHRNA5 variant rs16969968 alters how dopaminergic function changes during progression toward nicotine addiction and during nicotine withdrawaA
Giordano de GuglielmoIdentification of genetic variants that contribute to compulsive cocaine and oxycodone intake in rats: Preliminary data and establishment of the cocaine/oxycodone biobanks6
Rajeev DesaiRole of N-Methyl-D-Aspartate Receptor (NMDAR) in Co-Morbid Schizophrenia and Substance AbuseD
Danielle DickThe Spit for Science project: Characterizing Genetic and Environmental Influences on Patterns of Substance Use in College StudentsD
Ditte DemontisGenome-wide association study implicates CHRNA2 in cannabis use disorder5
Elizabeth DoPrenatal Smoke Exposure during Pregnancy and ADHD Symptoms within Offspring: An Examination of Sex Differences and Mediation by DNA Methylation MarkersA
Stella DrachevaRegulatory signatures in primate neurons at cell type resolution4
Aimee DudleyHigh resolution genetic dissection of complex and quantitative traits in yeast1
John DziakThe Effect of Varenicline on Ethanol Consumption and Striatal Gene Expression Using Classical Analytical Tools and High-Dimensional Mediation AnalysisB
Howard EdenbergTransancestral meta-analysis of alcohol dependence identifies novel genetic correlationsA
Marissa EhringerProfiling differential expression of miRNA in prefrontal cortices of tobacco smokers vs. non-smokersA
Michael EngelnTranscriptional adaptations in the ventral pallidum following cocaine self-administrationD
Prabagaran EsakkyPaternal exposure to cigarette smoke toxicants causes adverse developmental, neurological, and behavioral outcomes in the offspringC
Babak Esmail-AzadOpioid Addiction Susceptibility Testing Via Cytochrome P450 Pharmacogenetic And Personalized Brain Region Specific (VTA) Organoid AssaysB
Earl EttiennePharmacogenetics and Opioid Use DisorderC
Christie FowlerNicotine-Mediated Modulation of Choroid Plexus Function and Altered Circulating MicroRNA ExpressionD
Reza GhanbariMetabolomics Investigation of Opiate Addiction: Golestan Cohort StudyC
Tom GouldEffects of Nicotine Exposure During Adolescence on Adult Cognition, Dendritic Morphology, and EpigenomeC
Leonardo  GuercioThe Blackfynn Platform for Rapid, Multi-Modal Data Integration, Analysis, and Collaboration to Enable New Approaches to Drug Addiction ResearchC
Peter HamiltonEngineering CRISPR constructs as tools for gene-targeted transcriptional reprogramming in mammalian brain to elucidate the causal pathogenic mechanisms of drug abuseA
Joe HarfordA Nanocomplex Carrying siRNA Targeting TNFa with Potential to Blunt the Neuroinflammation that Underlies Opioid ToleranceB
Elaine Hebda-BauerGenetics of Novelty Seeking and Propensity for Drug Abuse in Outbred Rats6
Chad HighfillCandidate Genes for Cocaine and Methamphetamine Preference in Drosophila melanogasterA
Andrew JaffeEffects of smoking during pregnancy on the prenatal cortical transcriptomeB
Eric JohnsonNIDA Genetics Consortium Genome-wide Association Study of Opioid Addiction – Wave 12
Emma  JohnsonLarge genomewide association study of cannabis dependence: updates from the Substance Use Disorders working group of the Psychiatric Genomics ConsortiumD
Angela JunglenThe role of CAMK2A in the comorbidity of PTSD/SUD in individuals seeking detoxification treatmentD
Caline KaramGenome-wide association analysis of amphetamine sensitivity in Drosophila melanogasterA
Marcus KaulChronic, low dosage methamphetamine modifies memory performance compromised by exposure to HIV-1 Tat proteinA
Vivek KumarCYFIP2 mediated control of cocaine induced neuroadaptations in miceA
Daniel LarachIdentifying genetic predictors of perioperative opioid use through a prospective cohort of genotyped and phenotyped surgical patients: The Michigan Genomics InitiativeB
Todd LenczLarge-scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug TargetsD
Dawei LiDeletions in the SLC25A18 and ZNF490 Genes Associated with Alcohol Dependence–A Genome-wide Copy Number Variation Screen8
Xuan LiRole of dorsal striatal histone deacetylase 5 in incubation of methamphetamine cravingC
Yutao LiuSerum Exosomes and miRNAs in Male and Female Current, Former and Non-SmokersC
Ryan LoganCircadian Rhythms and Opiates: Role of the Circadian Transcription Factor NPAS2 to Regulate Morphine Conditioned RewardC
Elizabeth LongThe moderating roles of peer group deviance and parental monitoring on polygenic risk for alcohol use across adolescenceB
Qing LuA New Artificial Intelligence Tool for Substance Use and Dependence Research5
Trudy MacKayWhere is the Missing Heritability Hiding? Lessons From Drosophila1
Pamela MaddenGenetics and Epigenetics: the Addiction Phenotype, and the Adolescent Brain and Cognitive Development StudyB
Supriya MahajanSystems Biology Approach to Analysis of the Oral Microbiome in HIV-positive Opiate abusersB
Cecilia MarcondesReactive Oxygen Species induced in innate immune cells by Methamphetamine impact RNA polymerase binding patterns and facilitate the AP-1-mediated transcription of IL1beta and TNFalphaB
Christina MarkunasGenetically driven gene expression associated with nicotine dependence across ten brain regions reveals novel genes and brain regions3
Luke MatthewsCorrecting for Genetic and Cultural Nonindependence (Galton’s Problem) when Testing Genetic Associations with Substance AbuseC
Ian MazeAberrant histone dopaminylation in the ventral tegmental area promotes relapse to cocaine9
Jacquelyn  MeyersEarly Trauma Exposure, Polygenic risk for AUD, and Neural Response Inhibition in Adolescence and Young Adults: Trajectories of Frontal Oscillations during a Go/NoGo TaskC
Jacquelyn  MeyersInteraction Between Polygenic Risk for Cannabis Use and Environmental Exposures In The Detroit Neighborhood Health StudyC
Michael MilesGenetic Analysis of Intermittent Access Ethanol Consumption in Diversity Outbred (DO) and Progenitor Mouse StrainsC
Mahesh MohanDelta-9-Tetrahydrocannabinol mediated attenuation of gastrointestinal dysfunction in chronic SIV-infected rhesus macaques involves differential modulation of epithelial DNA methylation and T cell activationD
Janitza Montalvo-OrtizEpigenome-wide association study of opioid dependence in European American womenC
Mike NealeMeasurement Non-invariance with Respect to Race and Gender in DSM Criteria for Substance Abuse and DependenceD
Elliott NelsonRetrospective accounts of subjective effects of initial opioid use differ between those with opioid use disorder (OUD) and opioid misusers who never progressed to OUDC
Sean O'SullivanOpioid Withdrawal Shifts Amygdalar Transcriptome and is Correlated with Gut DysbiosisA
Chioma OkeomaHIV and substance abuse may influence the evolution of exosomes (exosome speciation): Implication for biosignatureD
Abe PalmerGenome wide association study of behavioral, physiological and gene expression traits in a multigenerational mouse intercrossB
Rohan PalmerMultivariate Genetics Architecture of DSM-5 Alcohol Use DisorderB
Ying-Xian PanAberrant alternative pre-mRNA splicing of the mu opioid receptor gene, OPRM1, in the medial prefrontal cortex of human heroin abusers and heroin self-administering ratsD
Ying-Xian PanThe role of alternatively spliced mu opioid receptor C-terminal tails in morphine tolerance, physical dependence and rewardD
Clarissa ParkerMeasuring negative affective withdrawal in CFW mice: A pilot studyA
Qian PengGenome-wide studies uncover a potential burden of uncommon variants and polygenic basis of multiple-substance use disorders in an American Indian populationD
Francesca PeruzziA miRNA signature for cognitive deficits and alcohol use disorder in persons living with HIV/AIDSD
Andreas PfenningCell type and Brain Region-specific Impact of Nicotine Use-associated Genetic Variation4
Robert PhilibertThe Dose Response and Abstinence induced Reversion Curves for Cigarette and Alcohol Consumption using Clinically Implementable Droplet Digital PCR AssaysD
Tamara PhillipsMA intake and sensitization in mice with a non-functional trace amine-associated receptor 1A
Renato PolimantiGenome-wide association study of opioid dependence in 3,491 cases and 4,163 exposed-controls from the Psychiatric Genomics ConsortiumA
Dina PopovaImpact of OPRM1 A118G on synaptic transmission in both human and mouse neuronsD
Elizabeth Prom-WormleyGenetic and Environmental Contributions to Electronic and Conventional Cigarette Use in Young Adults: A Bivariate AnalysisC
Sathya PuthanveettilA Long Noncoding RNA Critical for Synapse FunctionB
Jill RabinowitzThe Contributions of Genetic and Contextual Factors to Alcohol and Marijuana Use and Disorders in African-American Young AdultsC
Upal RoyRole of DJ1 gene in cocaine addiction and HIV-associated cognitive impairmentD
Laura SabaIntroducing the NIDA Core Center of Excellence in Omics, Systems Genetics, and the Addictome6
Sarven SabunciyanTranscriptome Differences In the Aging Schizophrenia BrainB
Wolfgang SadeeCombined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependenceA
Yotam SagiChromatin Remodeling Complex in Accumbal Neurons Regulates Reward and Pleasure B
April ShuDNA methylation markers associated with injection drug use status and HIV infection among chronic injection drug users in the ALIVE studyC
Dani SistoA Novel Approach to Accounting for Exposure in Genetic Association Studies of Drug Use Disorders – An UpdateD
Christopher SkipwithBuilding a Predictive Quantitative Genomics Framework for Identifying Endophenotypes in Opioid-Dependent PatientsC
Matthew SloanThe OPRM1 A118G Polymorphism and Alcohol-Related Phenotypes: Converging Evidence Against Associations with Alcohol Sensitivity and ConsumptionB
Lauren SloskySelf-Administration in Genetically Modified Mice: A Streamlined Platform for the Identification of Addiction Biomarkers, Therapies and Disease MechanismsB
Kristy SoloskiCan family cohesion buffer genetic risk for alcohol use trajectories?B
Bethany StanglDopamine Transporter (Dat1) Gene Variation And Intravenous Alcohol Self-Administration In Non-Dependent Drinkers: Influence Of Sex DifferencesB
Jerry StitzelParental nicotine exposure elicits multigenerational nicotine preference and ADHD-like brain, behavioral, and epigenetic anomalies in adolescent miceC
Laura StroudEpigenetic regulation of placenta NR3C1: Mechanism underlying the impact of prenatal marijuana on infant development?D
Boris TabakoffThe Construction of a Tool that Predicts the Pathways from the Genome to PhenotypeA
Yuan-XIing TaoContribution of DNMT3a to neuropathic pain genesis by downregulating Kcna2 in primary afferent neuronsD
Lisa TarantinoThe Collaborative Cross as a tool for studying the genetics of addiction-related phenotypesB
Allison TeggeDNA methylation levels as a biomarker for severity of opioid useC
Samikkannu ThangavelCocaine and HIV- Neuropathogenes: Epigenetic signature of DNA Methylation Role in Brain Energy MetabolismC
Thoprgeir ThorgeirssonResults from the Decode GWAS study on addiction2
Vanessa TroianiClinical and Genetic Risk Factors associated with Opioid Use Disorder in patients with Chronic PainB
Eric TurnerChrna5-expressing neurons in the interpeduncular nucleus mediate aversion primed by prior stimulation or nicotine exposureA
Jill TurnerDisruption of Hippocampal NRG3-ErbB4 Signaling Ablates Nicotine Withdrawal-Induced Anxiety-like BehaviorsA
Mudit TyagiCocaine-stimulated MSK1 promotes HIV transcription/replication both by augmenting the activity/recruitment of transcription factors and inducing euchromatin structures at HIV LTRB
John VanMeterThe Role of DRD2 in Adolescent Reward ProcessingD
Jasmin  VassilevaNeurocognitive and personality dimensions of impulsivity as common and specific candidate endophenotypes for opiate and stimulant dependenceC
Norma VelazquezA Drosophila model for developmental nicotine exposureA
Scott VriezeGenetic associations with alcohol and nicotine use3
Deena WalkerAdolescent Social Stress Results in Sex-Specific Transcriptional Reprogramming of The Medial Amygdala, A Critical Region for Sex Differences in RewardB
Gemma WallaceApplying advanced statistical modeling to genetic predictors of personality dimensions associated with addictionD
Consuelo Walls-BassGene Expression Profiling in the Dorsolateral Prefrontal Cortex of Subjects with Completed Suicide and Substance AbuseB
Raymond WaltersClosing the gap on "missing" heritability1
Frances WangRole of Genetically-Influenced 5-HT Functioning in a Bifactor Model of Psychopathology: Moderation by Fathers’ Substance Use DisorderD
Craig WernerTrim3 mediates cocaine craving via INO80-dependent transcriptional regulationB
Jennifer WolstenholmeAdolescent binge ethanol alters oligodendrocyte maturation and regulation of histone methylation in the PFCC
Ke XuDNA methylation related to HIV-infected smoking associated with mortality in HIV-infected individualsC
Abstracts from November 2016 meeting
SubmitterTitle of AbstractSessionNumber
Abraham PalmerGenome-wide association study of delay discounting identifies GPM6B and demonstrates co-heritability with smokingOral Presentation I1
Arpana AgrawalPsychiatric Genetics Consortium UpdateOral Presentation I2
Thorgeir ThorgeirssonPolygenic risk scores for schizophrenia and bipolar disorder associate with addictionOral Presentation I3
Andrew BergenSmokescreen Translational Analysis Platform: Prediction of Nicotine Metabolism and Smoking CessationOral Presentation I4
Deborah MashHuman Transcriptome Analysis of Cocaine Abuse Identifies Genes Associated with Adult Striatal NeurogenesisOral Presentation II1
Amanda MitchellLongitudinal Assessment of Neuronal 3D Genomes in Mouse Prefrontal CortexOral Presentation II2
Changning WangEPIS - Epigenetic PET imaging in substance use disorder patientsOral Presentation II3
Heidi O'NeillModeling gene x environmental effects in the mouse: the multigenerational phenotypes of the interaction of the rs16969968 SNP with developmental nicotine exposure.Oral Presentation II4
Venetia ZachariouA unique role of RGSz1 in behavioral responses to pain killersPoster Session I1
Yi ZhangNeuron subtype-specific molecular profiling and gene editing in a mouse model of cocaine addictionPoster Session I2
John RiceTargeted sequencing identifies genetic polymorphisms of flavin-containing monooxygenase genes that contribute to the risk of nicotine dependence in European and African AmericansPoster Session I3
Alan R. ProssinGenetic moderation of human sTNFR1 response to experimental pain: potential homeostatic mechanisms underlying endogenous analgesia.Poster Session I4
Makoto TaniguchiHDAC5 and NPAS4 regulate cocaine reward-environment associationsPoster Session I5
Patrick J. MuhollandIntegrative synaptomics in heavy drinking macaques identifies cross-species proteogenetic targets for treating excessive drug-seekingPoster Session I6
Scott J. MoellerGenetic Markers Associated with Brain Structural Abnormalities in Human Cocaine AddictionPoster Session I7
Caline KaramDelineating the genetic basis of amphetamine sensitivity using a Drosophila behavioral modelPoster Session I8
David JentschIntravenous Cocaine Self-Administration in Inbred Mice: Genetic Correlation with Impulsivity and Genome-Wide Association ResultsPoster Session I9
Abraham PalmerGenome-wide association study of behavioral, physiological and gene expression traits in outbred CFW mice.Poster Session I10
Kirk WilhelmsenGenome-wide meta-analysis identifies seven novel susceptibility signals for nicotine dependencePoster Session I11
Laura SabaAn Influential Novel Transcript in a Systems Genetic Model of Alcohol ConsumptionPoster Session I12
Betsy FergusonA Genome-Wide Approach to Efficiently Identify Replicable DNA Methylation Regions Associated with Alcohol UsePoster Session I13
Miri GitikCholine supplementation in an adolescent nicotine exposure model- a whole genome epigenetic perspective.Poster Session I14
Arpana AgrawalGenomewide association study identifies a novel locus for cannabis dependencePoster Session I15
S. ZHONGAlcohol-induced histone H3 phosphorylation mediats RNA Pol III gene transcriptionPoster Session I16
Alfredo GhezziCBP mediated control of long-term drug neuroadaptation in DrosophilaPoster Session I17
Mahesh MohanDelta-9-Tetrahydrocannabinol mediated attenuation of intestinal inflammation in chronic SIV-infected rhesus macaques involves differential modulation of anti-microbial defensins, pro-inflammatory gene and microRNA expression amidst high viral loadsPoster Session I18
Danielle DickThe Spit for Science project: Characterizing Genetic and Environmental Influences on Patterns of Substance Use in College StudentsPoster Session I19
Diana FishbeinInteractions between DAT1 and OPRM1, subcortical volume and later alcohol use in alcohol naïve youth.Poster Session I20
Kristine MarceauCortisol-related Genes and Substance Use Severity at age 16 yearsPoster Session I21
Mary Kay LoboCell subtype transcriptional regulation of mitochondrial dynamics in cocaine actionPoster Session I22
Yuva KondaveetiCocaine Induces changes in the expression of lncRNAs in T cellsPoster Session I23
Marcus KaulHIV-1/gp120 protein and methamphetamine induce lasting alterations in four major neurotransmission systems of the central nervous systemPoster Session I24
Chioma M. OkeomaCocaine alters semen exosome cargo composition and anti-HIV activityPoster Session I25
Andew J. RennekampTarget-agnostic CNS drug discovery using high-throughput behavioral chemical screening in zebrafish larvae identifies a new role for sigma-1 receptors in the vertebrate brain.Poster Session I26
Qing LuA New Method Founds Evidence of Genetic Heterogeneity in Nicotine DependencePoster Session I27
Jennifer T. WolstenholmeAdolescent binge ethanol alters histone methylation in the PFC leading to lasting memory deficits and increased ethanol sensitivityPoster Session I28
Chris BizonAssociation and Linkage Analysis of Nicotine Dependence from Whole Genome Sequencing of Family Data Suggest a Novel Role for BBS5Poster Session I29
Darius BostAssociation of addiction phenotypes to predicted transcript levelsPoster Session I30
Gustavo TureckiImpact of chronic cocaine use on the human striatum methylomePoster Session I31
Elisa M. TruccoA Developmental Perspective on the Role of Genes on Substance Use DisorderPoster Session II1
Frederick WolfSIR2/SIRT1 Disinhibition of Gene Expression by Acute Alcohol Leads to Presynaptic Changes and Behavioral PlasticityPoster Session II2
Joseph BloomNicotine Dependence Associated with Functional Variation in FMO3Poster Session II3
Peter HamiltonEngineering zinc-finger protein and CRISPR/Cas9 constructs to model the epigenetic and transcriptional phenomena that underlie cocaine-related behaviorsPoster Session II4
Clarissa ParkerGenome-wide mapping of ethanol sensitivity in the Diversity Outbred mouse populationPoster Session II5
Boris TabakoffThe Hybird Rat Diversity Rat Panel for Addiction ResearchPoster Session II6
Lindsay FarrerGenome-wide Association Study of Amphetamine Related Stimulant DependencePoster Session II7
Brian SmithThe genetic and epigenetic architecture of behaviors related to drug seeking and abuse: The honey bee as a new animal modelPoster Session II8
Scott MackeyGenetic risk and nicotine exposure interact on the structure and function of the ventromedial prefrontal cortex in adolescentsPoster Session II9
Travis T. MallardGenome-wide polygenic scores for schizophrenia are associated with substance use during emerging adulthoodPoster Session II10
Lisa GoldbergIdentification of a major QTL influencing oxycodone behavioral sensitivity and dependence in C57BL/6 substrainsPoster Session II11
David BrazelInterim results from the GSCAN exome chip projectPoster Session II12
Robert PhilibertQuantitative DNA Methylation Analyses Using Digital Droplet PCR Sensitively Detects Surreptitious Smoking in Adolescents.Poster Session II13
Phillip K. LiuEpigenetics of Drug Sensitization: MicroRNA and HDAC5 expression in Amphetamine-induced Neural RemodelingPoster Session II14
Gal YadidTime Window for DNA methylation in Incubation of Cocaine CravingPoster Session II15
Fereshteh S. NugentEpigenetic reversal of maternal deprivation-induced dopamine cell hyperexcitability and synaptic mislocalization of AKAP150 within the VTAPoster Session II16
Pam MaddenGenetics, the Addiction Phenotype, and the Adolescent Brain and Cognitive Development StudyPoster Session II17
Ana VentuneacIntegrated (iCare) at Mt. SinaiPoster Session II18
Michael StallingsEtiological Overlap Between Impaired Sex and Risky Sexual BehaviorPoster Session II19
Kyung-An HanGenetic and social factors critical for inhibitory controlPoster Session II20
Rudra PratyaydiptaEffect of microRNA expression on alcoholism: A study in a panel of recombinant inbred mouse strainsPoster Session II21
Erin CalipariWithdrawal from cocaine self-administration alters the transcriptional profile of cocaine across six brain regionsPoster Session II22
Bradley E. AouizeratThe Women’s Interagency HIV Study (WIHS): A Diverse Cohort Well Suited to Molecular Epidemiology Studies of Substance AbusePoster Session II23
Ron HartIncreased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allelePoster Session II24
Jiang GuiEfficient Survival Multifactor Dimensionality Reduction Method for Detecting Gene-Gene InteractionPoster Session II25
Anna Dorothy AsimesPre-conception Maternal and Paternal Binge Alcohol Exposure Lead to Distinct DNA Methylation Patterns in Alcohol-Naive Male OffspringPoster Session II26
Jinbo BiMulti-view Singular Value Decomposition for Disease Subtyping and Genetic AssociationsPoster Session II27
Ming D. LiA second update on susceptibility genes for nicotine dependence identified by genome-wide linkage, candidate gene association, genome-wide association, and targeted sequencing approachesPoster Session II28
Nora BizzozeroNeuronal enriched RNA-Binding Protein HuD and microRNA miR-495 oppositely regulate cocaine induced addiction-related gene expression and place preference behaviorPoster Session II29
Ke XuIdentifying the gene co-expression module for tobacco smoking that is regulated by DNA methylationPoster Session II30
Todd HulganMeth and Genetically-Predicted Expression of the Cytoskeletal Protein Spectrin Gene Neurocognitive Function in HIVPoster Session II31
Caroline BrownPharmacogenetic Modulation of the Behavioral Effects of Buprenorphine in a Mouse Model of the OPRM1 (A118G) PolymorphismPoster Session III1
Zhiping PangSynaptic mechanisms of OPRM1 A118G (MOR N40D) gene variants in human neuronsPoster Session III2
Ethan CarverGene Regulation and Viability of Cell Cultures Exposed to E-Cigarette Refill SolutionsPoster Session III3
Z Carl LinEIF3F Genetics of Substance AbusePoster Session III4
Dana HancockGenome-wide Interaction Analysis with Sex Reveals PEX11G as a Novel Gene for Nicotine DependencePoster Session III5
Paulo A. FerreiraControl of gene-environment interactions by the Ran-binding protein 2 (Ranbp2) and its stresssensing partners as venues to dissect the genetic basis of addiction behaviors engendered by drug abusePoster Session III6
Andon N. PlaczekeIF2α-mediated translational control regulates cocaine-and nicotine-induced synaptic potentiation in mouse midbrain dopamine neurons and neuronal responses in human smokersPoster Session III7
Tamara PhillipsEvidence for an epistatic effect of Oprm1 and Taar1 in risk for methamphetamine consumptionPoster Session III8
Roseann PetersonEvidence for shared genetic risk between schizophrenia and smoking behaviors: Findings from the Psychiatric Genomics Consortium.Poster Session III9
Renato PolimantiRisk alleles identified in a genome-wide gene-by-cannabis dependence interaction analysis of risky sexual behaviorsPoster Session III10
Camron BryantCytoplasmic FMR1-interacting protein 2 is a major genetic factor underlying binge eatingPoster Session III11
Shauna ClarkDiscovering methylation biomarkers of smoking and associated health risksPoster Session III12
Ashiwel UndiehPsychostimulant-induced Alterations in Epigenetic DNA Methylation of Neural Genes: Toward a Pharmacological Separation of Euphoric and Neuroadaptive Mechanisms?Poster Session III13
Pradeep BhideNicotine-induced DNA methylation in spermatozoa: Consequences for offspring’s behavior and gene expression in the brainPoster Session III14
Jinying ZhaoAn Epigenome Wide Association Study on Alcohol Consumption: A Monozygotic Twin StudyPoster Session III15
S.A. EisensteinDopamine-related Genetic Profile is Associated with Negative Symptom Severity, Reward Expectancy, and Behavioral InhibitionPoster Session III16
Su GuoExplore a natural variation of light/dark preference behavior in zebrafish: Genetic or epigenetic?Poster Session III17
Michael MilesBehavioral genomic and genetic analysis of chronic nicotine and withdrawal in mouse BXD strains.Poster Session III18
Johana AlvarezHeightened Baseline Anxiety-Like Behavior in Mice with Escalating Cocaine Consumption During Extended Access Cocaine Self-AdministrationPoster Session III19
Stephen L. BoehmShort-term selective breeding for adolescent sensitivity to tetrahydrocannabinol- (THC-) induced locomotor sedation in mice.Poster Session III20
Susan SmithHigh-Throughput Transcriptome Sequencing to Identify Genetic Modifiers of Sensitivity to AlcoholPoster Session III21
Christie FowlerNicotinic Modulation of the Choroid Plexus and Altered Circulating MicroRNA Expression During Chronic Nicotine Self-AdministrationPoster Session III22
Shilpa BuchCocaine-mediated promoter DNA methylation of microRNA-124 promotes microglial activation through TLR4 signalingPoster Session III23
Gary SiuzdakCloud-Based Systems Biology Analyses Guided by MetabolomicsPoster Session III24
Jinbo BiMachine learning to identify highly heritable components of substance use disordersPoster Session III25
Erika AndradeNeuronal Subtype-Specific Translational Changes Following Extended-Access Cocaine Self-Administration in MicePoster Session III26
Sudheesh Pilakka-KanthikeelCocaine reactivates latent HIV-1 by down regulating anti-HIV long-non coding RNAsPoster Session III27
Ming D. LiCharacterization of regulatory mechanisms at DNA variant, methylation and RNA levels for 57 tobacco smoking susceptibility genes in human brainPoster Session III28
Brion MaherCirculating DNA methylation markers associated with injection status and HIV infection among chronic injection drug users in the ALIVE study.Poster Session III29
Michele T. JuarezAcute exposure of Nicotine during Drosophila puncture injury activates an epidermal wound responsePoster Session III30
Richard C. CristA polymorphism in the OPRM1 3’ untranslated region is associated with methadone efficacy in treating opioid dependencePoster Session IV1
Imad DamajThe b3 subunit of the nicotinic acetylcholine receptor (nAChR) is required for nicotine withdrawal but not nicotine rewardPoster Session IV2
Igor ZhulinEstablishing the Precise Evolutionary History of a Gene Improves Prediction of Disease-causing Missense MutationsPoster Session IV3
Li-Shiun ChenGenetic risk can be decreased: Quitting smoking decreases and delays lung cancer for smokers with high and low CHRNA5 risk genotypes - A Meta-analysisPoster Session IV4
Xiangning ChenIntegration of Gene Expression in animal studies with GWAS in human datasets to Identify Risk Genes for Nicotine DependencePoster Session IV5
Jared BagleyThe effects of prenatal stress on cocaine reward, cocaine locomotion and sensorimotor processing are heritable in the BXD recombinant inbred strain panelPoster Session IV6
Rohan PalmerEstimation of the Genome-wide Additive Genetic Covariance Across Subjects of European and African Ancestry: An Example Using Alcohol DependencePoster Session IV7
Elliot NelsonMeta-analysis of comparisons to non-dependent misusers implicates CD244 involvement in opioid dependencePoster Session IV8
Kirk WilhelmsenWhole Genome Sequence Study of Cannabis Dependence: Associations with Regulatory Elements Identified by the Roadmap Epigenomics ProjectPoster Session IV9
Eric O. JohnsonMulti-ancestry GWAS Identifies Novel Variants Associated with HIV-1 Viral Load Set-pointPoster Session IV10
Laura StroundEpigenetic Regulation of Placental NR3C1: Mechanism Underlying Prenatal Programming of Infant Stress Response by Maternal Smoking During Pregnancy?Poster Session IV11
Shilpa BuchHIV-1 TAT-mediated epigenetic downregulation of miR-124 targets MECP2 and promotes microglial activationPoster Session IV12
Michelle M. JacobsHIV-related neurocognitive impairment is related to polymorphisms in CCR2 and CD163 in the absence of cocaine and opiate dependencyPoster Session IV13
Gregory SartorBET bromodomains regulate neurobehavioral responses to psychostimulantsPoster Session IV14
Viranu SueblingvongAlcohol induces profibrotic fibroblast phenotype via induction of DNA methyl transferase.Poster Session IV15
Jasmin VassilevaBehavioral Phenotypes of Impulsivity in Substance Dependent Individuals in Protracted Abstinence: Insights from ‘Pure’ Heroin and Amphetamine UsersPoster Session IV16
Andrew TalalTelemedicine-based Management of Hepatitis C Virus (HCV) Infection for Individuals on Opiate Agonist TreatmentPoster Session IV17
Brion MaherA Novel Approach to Accounting for Exposure in Association Studies of Drug Use DisordersPoster Session IV18
Rae SilverNovel noninvasive voluntary methamphetamine inhalation paradigm for long-term studies of neuroinflammation and drug-seeking behaviorPoster Session IV19
Kristin G. ArdlieSpecificity of alternative splicing in brain tissues from the GTEx projectPoster Session IV20
Narasimhan J. VenkatachariTranscriptome analysis of Peripheral Blood Mononuclear Cells from individuals with HIV-1 associated neurocognitive disorder identifies key players associated with neuropathogenesis and Marijuana use.Poster Session IV21
Pawel CirborowskiSystems biology approach reveals novel insights into altered functions of HIV-1-infected or methamphetamine exposed macrophages.Poster Session IV22
Lee CampbellCreation and characterization of the HIV-nanoLuc CHME-5 cell linePoster Session IV23
Bi XuanA Statistical Method for Advancing Neuroimaging GeneticsPoster Session IV24
Tom GouldPaternal nicotine exposure trans-generationally alters fear response and cholinergic function: potential epigenetic mechanismsPoster Session IV25
Dan IancuGenetic Selection for Methamphetamine Intake Rewires Brain Transcriptional NetworksPoster Session IV26
Fereshteh S. NugentChanges in neuronal excitability and histone modifications within the LHb may underlie anxiety and depression following early life stressesPoster Session IV27
Shuanglin HaoEpigenetic modification of MCU in the spinal cord dorsal horn in chronic morphine tolerance and HIV-related neuropathic pain statePoster Session IV28
Lucia CarvelliEmbryonic exposure to amphetamine alters the activity of the dopamine transporter in adult animals and progenyPoster Session IV29